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The map label for this gene is hisB

Identifier: 152974933

GI number: 152974933

Start: 1243498

End: 1244085

Strand: Direct

Name: hisB

Synonym: Bcer98_1130

Alternate gene names: 152974933

Gene position: 1243498-1244085 (Clockwise)

Preceding gene: 152974932

Following gene: 152974934

Centisome position: 30.43

GC content: 37.76

Gene sequence:

>588_bases
ATGATGCGCCGGGCAAGCCAAGAGAGACGAACAACAGAAACGAAAATTAAACTGCATTTACAGTTGGATGAAAGTGAAAA
TATTTCTATTCGAACTGGTGTTGGATTTTTTGATCATATGTTAACGTTGTTTGCAAAACATGGAAGATTTGGACTGCAAA
TTGAAGCAGTAGGCGATATGTTTGTTGATGCACATCACACTGTGGAAGATGTTGGTATTGTACTTGGGAATTGCTTGAGA
GAAGTTTTGCAAAATAAAGAGGGAATGAACCGTTATGGTGCAGCATATGTGCCGATGGATGAGGCATTAGGGTTTGTTGC
AATTGATATAAGCGGTAGGTCTTATCTTGTATTTCAAGGAGAACTAGTAAATCCAAAGTTAGGAGATTTTGATACAGAAC
TTACAGAGGAATTTTTCCGAGCAGTTGCCCACGCAGCTCATATAACATTACATGCACGCATTTTATATGGAAACAATACA
CATCACAAAATAGAAGCTTTATTTAAAGCATTTGGACGTGCGCTTCGAGAAGCTGTAGATAAAAATGAAAAGATTGTCGG
AATCAATTCTACGAAAGGAATGTTGTGA

Upstream 100 bases:

>100_bases
CGGCATTAAAAGATGTACAGCATCATATTATCAGTCTTGCTAATAAAGAAGGATTGCATGCACATACAAGAGCTATTCAA
ATTCGATTTGAGGAGGAGAA

Downstream 100 bases:

>100_bases
TTGATTGCAATTATAGACTATGGCATGGGAAATATTCGGAGTATAGAACAAGCATTAACATCTATTGGAGTGGAACATCT
TGTGACGGATCGTCAACGAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MMRRASQERRTTETKIKLHLQLDESENISIRTGVGFFDHMLTLFAKHGRFGLQIEAVGDMFVDAHHTVEDVGIVLGNCLR
EVLQNKEGMNRYGAAYVPMDEALGFVAIDISGRSYLVFQGELVNPKLGDFDTELTEEFFRAVAHAAHITLHARILYGNNT
HHKIEALFKAFGRALREAVDKNEKIVGINSTKGML

Sequences:

>Translated_195_residues
MMRRASQERRTTETKIKLHLQLDESENISIRTGVGFFDHMLTLFAKHGRFGLQIEAVGDMFVDAHHTVEDVGIVLGNCLR
EVLQNKEGMNRYGAAYVPMDEALGFVAIDISGRSYLVFQGELVNPKLGDFDTELTEEFFRAVAHAAHITLHARILYGNNT
HHKIEALFKAFGRALREAVDKNEKIVGINSTKGML
>Mature_195_residues
MMRRASQERRTTETKIKLHLQLDESENISIRTGVGFFDHMLTLFAKHGRFGLQIEAVGDMFVDAHHTVEDVGIVLGNCLR
EVLQNKEGMNRYGAAYVPMDEALGFVAIDISGRSYLVFQGELVNPKLGDFDTELTEEFFRAVAHAAHITLHARILYGNNT
HHKIEALFKAFGRALREAVDKNEKIVGINSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=44.6153846153846, Blast_Score=167, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=175, Percent_Identity=41.7142857142857, Blast_Score=150, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BACCN (A7GMU7)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374450.1
- ProteinModelPortal:   A7GMU7
- SMR:   A7GMU7
- STRING:   A7GMU7
- EnsemblBacteria:   EBBACT00000037827
- GeneID:   5344506
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1130
- eggNOG:   COG0131
- GeneTree:   EBGT00050000001667
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   BCER315749:BCER98_1130-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21929; Mature: 21929

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRASQERRTTETKIKLHLQLDESENISIRTGVGFFDHMLTLFAKHGRFGLQIEAVGDM
CCCCCHHHHHCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCH
FVDAHHTVEDVGIVLGNCLREVLQNKEGMNRYGAAYVPMDEALGFVAIDISGRSYLVFQG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEECCHHHCCCEEEEEECCCEEEEEEC
ELVNPKLGDFDTELTEEFFRAVAHAAHITLHARILYGNNTHHKIEALFKAFGRALREAVD
EECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
KNEKIVGINSTKGML
CCCEEEEECCCCCCC
>Mature Secondary Structure
MMRRASQERRTTETKIKLHLQLDESENISIRTGVGFFDHMLTLFAKHGRFGLQIEAVGDM
CCCCCHHHHHCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCH
FVDAHHTVEDVGIVLGNCLREVLQNKEGMNRYGAAYVPMDEALGFVAIDISGRSYLVFQG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEECCHHHCCCEEEEEECCCEEEEEEC
ELVNPKLGDFDTELTEEFFRAVAHAAHITLHARILYGNNTHHKIEALFKAFGRALREAVD
EECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
KNEKIVGINSTKGML
CCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA