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The map label for this gene is hisD [H]

Identifier: 152974932

GI number: 152974932

Start: 1242218

End: 1243501

Strand: Direct

Name: hisD [H]

Synonym: Bcer98_1129

Alternate gene names: 152974932

Gene position: 1242218-1243501 (Clockwise)

Preceding gene: 152974931

Following gene: 152974933

Centisome position: 30.39

GC content: 37.85

Gene sequence:

>1284_bases
ATGATTTGTAAGAACTTTATAGAAGGATTATCGAAAATAAAGTTGTTAAGAGAGCACACCTATATAATGGAAGAAACGAT
GCAAATACGTGTGAAGGAAATCGTTCAAAAAGTAAGAGAGAAAAGAGATACAGCACTATTTTCATATACAAAATTATTTG
ATGATATCCAATTAACACAGTTTCGTGTATCAAAAGAAGAAATAGAGAATGCACAGAAATCTGTTTCATCTGAATTTATA
GAGGCTTTACAAGAGGCAAAGAAAAATATCATATCCTATCATGAAAAGCAAAAAAGGCAATCGATATGTGATTATGAGGC
GAAGGGAATTATTCAGGGTCAACTCATCAGACCATTAGAAATAGTCGGTGTATATGTACCAGGCGGAACAGCTTCATATC
CTTCCTCGGTACTTATGAATACATTGCCGGCTAAAATTGCAGGTGTTCAAAAGGTTGTTATGGTAACACCACCAGGGAGA
AAGGGAGTAGACCCCTACATTTTAGTTGCCGCACAAATTGCAGGTGTAGATGAAATCTATACGGTGGGCGGTGCGCAAGC
AATTGCTGCTTTAGCATATGGAACGGAATCGATTCCAAAAGTTGATAAAATAGTTGGACCAGGAAATATATATGTGGCTT
TAGCAAAGAAAGAGGTATACGGAATAGTCGATATTGATATGATTGCCGGCCCTTCCGAAATTGTAGTAATTGCTGATGAA
ACGGGGAAAGCATCGTTTATTGCAGCAGATTTATTATCTCAAGCAGAGCATGATACGAGAGCAACTGCGATTTGTATTAC
AACAAGCGCAATATTAGCGTCAGAAATAGAAAGAGAGGTAAACGTGCAACTGCCAATGTTGCCAAGAAGTGAAATTGCTC
GTGAAGCGATAGAGAGAAATGGAGCAATCCTTATTGTTTCTTCGTTGACAGAAGCTTTTCAACTGTCAAATGAAATAGCC
CCAGAACATTTAGAGTTACATATAAAAGAACCGATGAATGCTTTACCATATATTCGGCATGCGGGTTCTATTTTTCTTGG
CCCCTATGCCCCAGAGCCGCTTGGAGATTATTTCGCAGGACCGAATCATGTGTTGCCAACGAGTGGAACAGCACGCTTTT
TTTCACCGTTATCAGTAGATGATTTTATTAAAAAATCTAGTTTTATTTCTTATACGAAAGCGGCATTAAAAGATGTACAG
CATCATATTATCAGTCTTGCTAATAAAGAAGGATTGCATGCACATACAAGAGCTATTCAAATTCGATTTGAGGAGGAGAA
ATGA

Upstream 100 bases:

>100_bases
GATTGTAAATAAAGCTGCTTTAAAAATGAAAAAAGACGAAATATTCAACATTATAAATAAAATAGAGTGTATCGTTTCTA
AAAAATAAAGGAGGGGTCAT

Downstream 100 bases:

>100_bases
TGCGCCGGGCAAGCCAAGAGAGACGAACAACAGAAACGAAAATTAAACTGCATTTACAGTTGGATGAAAGTGAAAATATT
TCTATTCGAACTGGTGTTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MICKNFIEGLSKIKLLREHTYIMEETMQIRVKEIVQKVREKRDTALFSYTKLFDDIQLTQFRVSKEEIENAQKSVSSEFI
EALQEAKKNIISYHEKQKRQSICDYEAKGIIQGQLIRPLEIVGVYVPGGTASYPSSVLMNTLPAKIAGVQKVVMVTPPGR
KGVDPYILVAAQIAGVDEIYTVGGAQAIAALAYGTESIPKVDKIVGPGNIYVALAKKEVYGIVDIDMIAGPSEIVVIADE
TGKASFIAADLLSQAEHDTRATAICITTSAILASEIEREVNVQLPMLPRSEIAREAIERNGAILIVSSLTEAFQLSNEIA
PEHLELHIKEPMNALPYIRHAGSIFLGPYAPEPLGDYFAGPNHVLPTSGTARFFSPLSVDDFIKKSSFISYTKAALKDVQ
HHIISLANKEGLHAHTRAIQIRFEEEK

Sequences:

>Translated_427_residues
MICKNFIEGLSKIKLLREHTYIMEETMQIRVKEIVQKVREKRDTALFSYTKLFDDIQLTQFRVSKEEIENAQKSVSSEFI
EALQEAKKNIISYHEKQKRQSICDYEAKGIIQGQLIRPLEIVGVYVPGGTASYPSSVLMNTLPAKIAGVQKVVMVTPPGR
KGVDPYILVAAQIAGVDEIYTVGGAQAIAALAYGTESIPKVDKIVGPGNIYVALAKKEVYGIVDIDMIAGPSEIVVIADE
TGKASFIAADLLSQAEHDTRATAICITTSAILASEIEREVNVQLPMLPRSEIAREAIERNGAILIVSSLTEAFQLSNEIA
PEHLELHIKEPMNALPYIRHAGSIFLGPYAPEPLGDYFAGPNHVLPTSGTARFFSPLSVDDFIKKSSFISYTKAALKDVQ
HHIISLANKEGLHAHTRAIQIRFEEEK
>Mature_427_residues
MICKNFIEGLSKIKLLREHTYIMEETMQIRVKEIVQKVREKRDTALFSYTKLFDDIQLTQFRVSKEEIENAQKSVSSEFI
EALQEAKKNIISYHEKQKRQSICDYEAKGIIQGQLIRPLEIVGVYVPGGTASYPSSVLMNTLPAKIAGVQKVVMVTPPGR
KGVDPYILVAAQIAGVDEIYTVGGAQAIAALAYGTESIPKVDKIVGPGNIYVALAKKEVYGIVDIDMIAGPSEIVVIADE
TGKASFIAADLLSQAEHDTRATAICITTSAILASEIEREVNVQLPMLPRSEIAREAIERNGAILIVSSLTEAFQLSNEIA
PEHLELHIKEPMNALPYIRHAGSIFLGPYAPEPLGDYFAGPNHVLPTSGTARFFSPLSVDDFIKKSSFISYTKAALKDVQ
HHIISLANKEGLHAHTRAIQIRFEEEK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=414, Percent_Identity=42.2705314009662, Blast_Score=302, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=38.1861575178998, Blast_Score=280, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47043; Mature: 47043

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICKNFIEGLSKIKLLREHTYIMEETMQIRVKEIVQKVREKRDTALFSYTKLFDDIQLTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FRVSKEEIENAQKSVSSEFIEALQEAKKNIISYHEKQKRQSICDYEAKGIIQGQLIRPLE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEE
IVGVYVPGGTASYPSSVLMNTLPAKIAGVQKVVMVTPPGRKGVDPYILVAAQIAGVDEIY
EEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHEEEEHHHCCCHHHH
TVGGAQAIAALAYGTESIPKVDKIVGPGNIYVALAKKEVYGIVDIDMIAGPSEIVVIADE
CCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECCEEEEEEEEEECCCCEEEEEECC
TGKASFIAADLLSQAEHDTRATAICITTSAILASEIEREVNVQLPMLPRSEIAREAIERN
CCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCC
GAILIVSSLTEAFQLSNEIAPEHLELHIKEPMNALPYIRHAGSIFLGPYAPEPLGDYFAG
CCEEEEHHHHHHHHHHCCCCCCHHEEEECCCCCHHHHHHHCCCEEECCCCCCCCHHHCCC
PNHVLPTSGTARFFSPLSVDDFIKKSSFISYTKAALKDVQHHIISLANKEGLHAHTRAIQ
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
IRFEEEK
EEEECCC
>Mature Secondary Structure
MICKNFIEGLSKIKLLREHTYIMEETMQIRVKEIVQKVREKRDTALFSYTKLFDDIQLTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FRVSKEEIENAQKSVSSEFIEALQEAKKNIISYHEKQKRQSICDYEAKGIIQGQLIRPLE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEE
IVGVYVPGGTASYPSSVLMNTLPAKIAGVQKVVMVTPPGRKGVDPYILVAAQIAGVDEIY
EEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHEEEEHHHCCCHHHH
TVGGAQAIAALAYGTESIPKVDKIVGPGNIYVALAKKEVYGIVDIDMIAGPSEIVVIADE
CCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECCEEEEEEEEEECCCCEEEEEECC
TGKASFIAADLLSQAEHDTRATAICITTSAILASEIEREVNVQLPMLPRSEIAREAIERN
CCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCC
GAILIVSSLTEAFQLSNEIAPEHLELHIKEPMNALPYIRHAGSIFLGPYAPEPLGDYFAG
CCEEEEHHHHHHHHHHCCCCCCHHEEEECCCCCHHHHHHHCCCEEECCCCCCCCHHHCCC
PNHVLPTSGTARFFSPLSVDDFIKKSSFISYTKAALKDVQHHIISLANKEGLHAHTRAIQ
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
IRFEEEK
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]