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The map label for this gene is hisG

Identifier: 152974931

GI number: 152974931

Start: 1241573

End: 1242205

Strand: Direct

Name: hisG

Synonym: Bcer98_1128

Alternate gene names: 152974931

Gene position: 1241573-1242205 (Clockwise)

Preceding gene: 152974930

Following gene: 152974932

Centisome position: 30.38

GC content: 32.7

Gene sequence:

>633_bases
ATGCGTAACGTTCAAATTGCATTAACAAAAGGAAGGCTTGAAAAGCATGTTATACCACTATTTGAACAAATCGGTATGGA
TTGTTCAGAGATGATGGATAAGGGAAGGAAGCTTACTTTCAAAAGTAACAATTCAAATGTTTCATTTATTTTAGTGAAGG
CGGTTGATGTTGCAACCTATGTAGAACATGGAGTTGCAGATATAGGGATTGTAGGAAAAGATATTTTAATGGAGTATGAG
AAAGATGTATATGAAATGATAGATTTACAGGTCGGATGTTGCAAATTGTGTATTGCATCTATTCCTGCATATGACCCGAA
AAAGTATAGAAAAAAGAGAATTGCGACGAAATACCCGTCTATTACTTCAAGATATTTTTGTGATAAAGGCGAAGATGTAG
AGATCATTAAAATTGAAGGCTCTGTAGAAATTGCTCCGCTTCTTGGTTTAGTAGATGCAATTGTAGATATTGTAGAAACA
GGGAAAACGTTGCAAGAAAATGGCTTAATTGTATTGGAAGAGATGTATCCAATATCAGCGCGAATGATTGTAAATAAAGC
TGCTTTAAAAATGAAAAAAGACGAAATATTCAACATTATAAATAAAATAGAGTGTATCGTTTCTAAAAAATAA

Upstream 100 bases:

>100_bases
GAAAGAAGAGCATTCAAACAGTTATTGAAGTGACAGAAACATCACTAGTGGAATATGCTTGGAAAGATAAATGGCTTAGG
AAGAAGGAGGGAGAAACTAC

Downstream 100 bases:

>100_bases
AGGAGGGGTCATATGATTTGTAAGAACTTTATAGAAGGATTATCGAAAATAAAGTTGTTAAGAGAGCACACCTATATAAT
GGAAGAAACGATGCAAATAC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRNVQIALTKGRLEKHVIPLFEQIGMDCSEMMDKGRKLTFKSNNSNVSFILVKAVDVATYVEHGVADIGIVGKDILMEYE
KDVYEMIDLQVGCCKLCIASIPAYDPKKYRKKRIATKYPSITSRYFCDKGEDVEIIKIEGSVEIAPLLGLVDAIVDIVET
GKTLQENGLIVLEEMYPISARMIVNKAALKMKKDEIFNIINKIECIVSKK

Sequences:

>Translated_210_residues
MRNVQIALTKGRLEKHVIPLFEQIGMDCSEMMDKGRKLTFKSNNSNVSFILVKAVDVATYVEHGVADIGIVGKDILMEYE
KDVYEMIDLQVGCCKLCIASIPAYDPKKYRKKRIATKYPSITSRYFCDKGEDVEIIKIEGSVEIAPLLGLVDAIVDIVET
GKTLQENGLIVLEEMYPISARMIVNKAALKMKKDEIFNIINKIECIVSKK
>Mature_210_residues
MRNVQIALTKGRLEKHVIPLFEQIGMDCSEMMDKGRKLTFKSNNSNVSFILVKAVDVATYVEHGVADIGIVGKDILMEYE
KDVYEMIDLQVGCCKLCIASIPAYDPKKYRKKRIATKYPSITSRYFCDKGEDVEIIKIEGSVEIAPLLGLVDAIVDIVET
GKTLQENGLIVLEEMYPISARMIVNKAALKMKKDEIFNIINKIECIVSKK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=222, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=212, Percent_Identity=32.5471698113208, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_BACCN (A7GMU5)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374448.1
- ProteinModelPortal:   A7GMU5
- SMR:   A7GMU5
- STRING:   A7GMU5
- EnsemblBacteria:   EBBACT00000038896
- GeneID:   5344496
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1128
- eggNOG:   COG0040
- GeneTree:   EBGT00050000002951
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   BCER315749:BCER98_1128-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23641; Mature: 23641

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVQIALTKGRLEKHVIPLFEQIGMDCSEMMDKGRKLTFKSNNSNVSFILVKAVDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHH
VEHGVADIGIVGKDILMEYEKDVYEMIDLQVGCCKLCIASIPAYDPKKYRKKRIATKYPS
HHHCCHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ITSRYFCDKGEDVEIIKIEGSVEIAPLLGLVDAIVDIVETGKTLQENGLIVLEEMYPISA
CHHHHCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHH
RMIVNKAALKMKKDEIFNIINKIECIVSKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNVQIALTKGRLEKHVIPLFEQIGMDCSEMMDKGRKLTFKSNNSNVSFILVKAVDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHH
VEHGVADIGIVGKDILMEYEKDVYEMIDLQVGCCKLCIASIPAYDPKKYRKKRIATKYPS
HHHCCHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ITSRYFCDKGEDVEIIKIEGSVEIAPLLGLVDAIVDIVETGKTLQENGLIVLEEMYPISA
CHHHHCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHH
RMIVNKAALKMKKDEIFNIINKIECIVSKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA