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The map label for this gene is hemY [H]

Identifier: 152974640

GI number: 152974640

Start: 941243

End: 942664

Strand: Direct

Name: hemY [H]

Synonym: Bcer98_0826

Alternate gene names: 152974640

Gene position: 941243-942664 (Clockwise)

Preceding gene: 152974639

Following gene: 152974642

Centisome position: 23.03

GC content: 40.15

Gene sequence:

>1422_bases
TTGAAAAAAAGAGTGGTTATCATTGGTGGTGGAATTGCGGGATTGACAGCAGCGTATTACTTGCAAAAAGAAATTCGTGA
ACAAGGGTTGCAGATTGATATGTTGTTAATAGAAGCGTCAGGTAAGGTTGGCGGGAAAATTCAAACCGTTCGAAAAGAAG
GATTTACAATTGAACGCGGCCCAGATTCTTTCCTCGAAAGAAAAGAAAGTGCAGCTCGATTGGTGAAAGAAGTCGGTTTA
GGAGACGAGCTTGTAAATAATAAAGCAGGTCAGTCATTTGTTCTTGTGAACAATCAATTGCACAAAATTCCGAGCGGATC
TATGATGGGAATTCCGACACAAATTACGCCGTTTCTATTTTCAGGATTGTTTTCTCCGATTGGTAAATTAAGGGCTAGTT
TTGATTTTGTACTTCCGCGTTCAAAACCAGTTTCGGATCAATCACTAGGCCAATTTTTTCGGCGTCGTTTCGGAAATGAA
GTGGTTGAAAATTTAATTGAACCATTGCTCGCTGGTATTTATGCAGGGGATATTGATCAAATGAGTTTGATGGCAACATT
CCCAAAAGTTTATCAAATAGAGCAGAAGTACCGCAGTATTTCGCTTGGTATGCGTGCGTTAGCACCAAAACGAACAAAAG
ATGTGAAACCAAAAGGGATGTTTCTAACATTAAAAACAGGCTTAGAGTCGTTAGTTGAGGCAATAGAAGAAAAACTTGAT
ACGAATACAGTGATGAAGGGAACGCGCGTTGAAAAAGTGAAAAAGCTGGGCGATGGCTATGAAATCACTCTTAGCAACGG
AAAAGAAATAGAGGCAGATGCAGTTATCATTGCAGCTCCGCATAAAGGATTGCCATCTATGTTCGGGCAGTATAAAGAGT
TCCGCTTCTTCCGCAATATTCCGGCAACCTCTGTAGCGAATGTCGCACTAGCTTTTCCGAAAGAAGCCATTAAGCGCGAT
ATTGATGGAACTGGATTTGTCGTATCAAGAAATAGTGATTTTTCCATTACAGCTTGCACGTGGGCACATAAAAAGTGGCC
ACATACAACGCCGGAAGGGAAAGTATTGTTGCGCTGCTATGTAGGGCGTCCTGGCGATGAAGCCATTGTAGAACAAACAG
ATGAAGAAATAATTCAATTTGTATTAGAAGATTTACAAAAAACAATGGATATAGTAGAGAGGCCAGACTTTACTGTCGTG
AGCCGCTGGAAAGATGCTATGCCGCAATATACAGTTGGACATAAAAAAAGAATGAAAAAACTAACAGCATTTCTAAAACA
AGAACTACCAGGCATATATTTAGCTGGTAGCTCCTATGCTGGCTCTGGTCTTCCAGATTGCATTGATCAAGGTGAGGCGG
CTGTAAAATATGTATTATCTTATTTAGAAGAACGCAATAAAACAAAATTAATCGCGCAATAA

Upstream 100 bases:

>100_bases
CCAAACGCATCGGAAGCATTTATCGATTGTTTAGCGGACGTTGTGCTTAAGAAACAAGAAGAAGTATTGTAATACTACAA
GCGAGAAAGGAGGGACTGTT

Downstream 100 bases:

>100_bases
TAATGAAAACAGGAGATCGGTGTCTCCTGTTTTTTTTGGTGTTCAAGCAACGGATATATAGGAATATATAAATTCAACTC
GCTATCGTTCTTTTCCACCA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKKRVVIIGGGIAGLTAAYYLQKEIREQGLQIDMLLIEASGKVGGKIQTVRKEGFTIERGPDSFLERKESAARLVKEVGL
GDELVNNKAGQSFVLVNNQLHKIPSGSMMGIPTQITPFLFSGLFSPIGKLRASFDFVLPRSKPVSDQSLGQFFRRRFGNE
VVENLIEPLLAGIYAGDIDQMSLMATFPKVYQIEQKYRSISLGMRALAPKRTKDVKPKGMFLTLKTGLESLVEAIEEKLD
TNTVMKGTRVEKVKKLGDGYEITLSNGKEIEADAVIIAAPHKGLPSMFGQYKEFRFFRNIPATSVANVALAFPKEAIKRD
IDGTGFVVSRNSDFSITACTWAHKKWPHTTPEGKVLLRCYVGRPGDEAIVEQTDEEIIQFVLEDLQKTMDIVERPDFTVV
SRWKDAMPQYTVGHKKRMKKLTAFLKQELPGIYLAGSSYAGSGLPDCIDQGEAAVKYVLSYLEERNKTKLIAQ

Sequences:

>Translated_473_residues
MKKRVVIIGGGIAGLTAAYYLQKEIREQGLQIDMLLIEASGKVGGKIQTVRKEGFTIERGPDSFLERKESAARLVKEVGL
GDELVNNKAGQSFVLVNNQLHKIPSGSMMGIPTQITPFLFSGLFSPIGKLRASFDFVLPRSKPVSDQSLGQFFRRRFGNE
VVENLIEPLLAGIYAGDIDQMSLMATFPKVYQIEQKYRSISLGMRALAPKRTKDVKPKGMFLTLKTGLESLVEAIEEKLD
TNTVMKGTRVEKVKKLGDGYEITLSNGKEIEADAVIIAAPHKGLPSMFGQYKEFRFFRNIPATSVANVALAFPKEAIKRD
IDGTGFVVSRNSDFSITACTWAHKKWPHTTPEGKVLLRCYVGRPGDEAIVEQTDEEIIQFVLEDLQKTMDIVERPDFTVV
SRWKDAMPQYTVGHKKRMKKLTAFLKQELPGIYLAGSSYAGSGLPDCIDQGEAAVKYVLSYLEERNKTKLIAQ
>Mature_473_residues
MKKRVVIIGGGIAGLTAAYYLQKEIREQGLQIDMLLIEASGKVGGKIQTVRKEGFTIERGPDSFLERKESAARLVKEVGL
GDELVNNKAGQSFVLVNNQLHKIPSGSMMGIPTQITPFLFSGLFSPIGKLRASFDFVLPRSKPVSDQSLGQFFRRRFGNE
VVENLIEPLLAGIYAGDIDQMSLMATFPKVYQIEQKYRSISLGMRALAPKRTKDVKPKGMFLTLKTGLESLVEAIEEKLD
TNTVMKGTRVEKVKKLGDGYEITLSNGKEIEADAVIIAAPHKGLPSMFGQYKEFRFFRNIPATSVANVALAFPKEAIKRD
IDGTGFVVSRNSDFSITACTWAHKKWPHTTPEGKVLLRCYVGRPGDEAIVEQTDEEIIQFVLEDLQKTMDIVERPDFTVV
SRWKDAMPQYTVGHKKRMKKLTAFLKQELPGIYLAGSSYAGSGLPDCIDQGEAAVKYVLSYLEERNKTKLIAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=496, Percent_Identity=28.6290322580645, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI4506001, Length=496, Percent_Identity=28.6290322580645, Blast_Score=151, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24649745, Length=448, Percent_Identity=24.5535714285714, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52597; Mature: 52597

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRVVIIGGGIAGLTAAYYLQKEIREQGLQIDMLLIEASGKVGGKIQTVRKEGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEHHHCCCEEECC
PDSFLERKESAARLVKEVGLGDELVNNKAGQSFVLVNNQLHKIPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRASFDFVLPRSKPVSDQSLGQFFRRRFGNEVVENLIEPLLAGIYAGDIDQ
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MSLMATFPKVYQIEQKYRSISLGMRALAPKRTKDVKPKGMFLTLKTGLESLVEAIEEKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
TNTVMKGTRVEKVKKLGDGYEITLSNGKEIEADAVIIAAPHKGLPSMFGQYKEFRFFRNI
CHHHHCCHHHHHHHHCCCCEEEEECCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHCC
PATSVANVALAFPKEAIKRDIDGTGFVVSRNSDFSITACTWAHKKWPHTTPEGKVLLRCY
CCHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEEE
VGRPGDEAIVEQTDEEIIQFVLEDLQKTMDIVERPDFTVVSRWKDAMPQYTVGHKKRMKK
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHH
LTAFLKQELPGIYLAGSSYAGSGLPDCIDQGEAAVKYVLSYLEERNKTKLIAQ
HHHHHHHHCCCEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKRVVIIGGGIAGLTAAYYLQKEIREQGLQIDMLLIEASGKVGGKIQTVRKEGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEHHHCCCEEECC
PDSFLERKESAARLVKEVGLGDELVNNKAGQSFVLVNNQLHKIPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRASFDFVLPRSKPVSDQSLGQFFRRRFGNEVVENLIEPLLAGIYAGDIDQ
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MSLMATFPKVYQIEQKYRSISLGMRALAPKRTKDVKPKGMFLTLKTGLESLVEAIEEKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
TNTVMKGTRVEKVKKLGDGYEITLSNGKEIEADAVIIAAPHKGLPSMFGQYKEFRFFRNI
CHHHHCCHHHHHHHHCCCCEEEEECCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHCC
PATSVANVALAFPKEAIKRDIDGTGFVVSRNSDFSITACTWAHKKWPHTTPEGKVLLRCY
CCHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEEE
VGRPGDEAIVEQTDEEIIQFVLEDLQKTMDIVERPDFTVVSRWKDAMPQYTVGHKKRMKK
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHH
LTAFLKQELPGIYLAGSSYAGSGLPDCIDQGEAAVKYVLSYLEERNKTKLIAQ
HHHHHHHHCCCEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]