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The map label for this gene is hemH [H]

Identifier: 152974639

GI number: 152974639

Start: 940279

End: 941214

Strand: Direct

Name: hemH [H]

Synonym: Bcer98_0825

Alternate gene names: 152974639

Gene position: 940279-941214 (Clockwise)

Preceding gene: 152974638

Following gene: 152974640

Centisome position: 23.01

GC content: 39.32

Gene sequence:

>936_bases
ATGAAAAAGAAAATTGGTTTGCTTGTTATGGCATACGGAACACCATATAAAGAAGAGGATATTGAACGTTACTATACGCA
TATTCGTAGAGGACGAAAGCCAAGTCCTGAAATGTTACAGGATTTAACAGAGCGTTATCGTGCGATTGGTGGTATTTCTC
CTTTAGCTGCTATTACATTAGAACAAGCGAAAAGACTAGAACAGCGTTTAAATGAAATGCAGGATGATGTGGAATTTCAT
ATGTATCTTGGGTTAAAGCATATTGAGCCTTTTATTGAAGATGCTGTACAAGCTATGCATCGTGATGGAATAAAAGAGGC
GATTGCTCTTGTTCTTGCCCCTCATTATTCTACTTTTAGCGTGAAATCTTATATTGGACGAGCACAAGAAGAAGCAGCGA
AATGTGAAGATTTAACGATTCATGGCATTGAGAGCTGGTATAAAGAGCCGAAATTTATTCAGTATTGGGTAGATGCGGTG
AAAAGCATATATGACGGCATGCCAGAAGAAGAACGTGAAAAAGCAGTTTTAATTGTATCTGCGCATAGTTTACCGGAAAA
AATTATCGCATTAGGCGACCCATATCCAGAGCAATTAAGTGAAACGGCAGAATATATTGCTCGTGGTGCAGAAGTTCCAA
ATTACGCGGTTGGTTGGCAAAGTGCCGGCAACACACCTGATCCATGGATTGGACCAGATGTGCAAGATTTAACGAAGGAG
CTGTATGAAAAGTACGGTTACACTTCATTTGTATATGCACCAGTTGGTTTTGTAGCGGAGCATTTGGAAGTATTATATGA
CAATGATATTGAATGTAAAATCGTTACAGATGAAATCGGGGCGAAATATTATCGCCCAGAGATGCCAAACGCATCGGAAG
CATTTATCGATTGTTTAGCGGACGTTGTGCTTAAGAAACAAGAAGAAGTATTGTAA

Upstream 100 bases:

>100_bases
TGTATTTCCAGAGGTGAATCCTGATACGTTAAAACGTTTAACAGCGTTTATTCATGAATATTCGAAAGAGCAGTTAGCGA
AGTAAAGGAGAATTAGGGGT

Downstream 100 bases:

>100_bases
TACTACAAGCGAGAAAGGAGGGACTGTTTTGAAAAAAAGAGTGGTTATCATTGGTGGTGGAATTGCGGGATTGACAGCAG
CGTATTACTTGCAAAAAGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLQDLTERYRAIGGISPLAAITLEQAKRLEQRLNEMQDDVEFH
MYLGLKHIEPFIEDAVQAMHRDGIKEAIALVLAPHYSTFSVKSYIGRAQEEAAKCEDLTIHGIESWYKEPKFIQYWVDAV
KSIYDGMPEEEREKAVLIVSAHSLPEKIIALGDPYPEQLSETAEYIARGAEVPNYAVGWQSAGNTPDPWIGPDVQDLTKE
LYEKYGYTSFVYAPVGFVAEHLEVLYDNDIECKIVTDEIGAKYYRPEMPNASEAFIDCLADVVLKKQEEVL

Sequences:

>Translated_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLQDLTERYRAIGGISPLAAITLEQAKRLEQRLNEMQDDVEFH
MYLGLKHIEPFIEDAVQAMHRDGIKEAIALVLAPHYSTFSVKSYIGRAQEEAAKCEDLTIHGIESWYKEPKFIQYWVDAV
KSIYDGMPEEEREKAVLIVSAHSLPEKIIALGDPYPEQLSETAEYIARGAEVPNYAVGWQSAGNTPDPWIGPDVQDLTKE
LYEKYGYTSFVYAPVGFVAEHLEVLYDNDIECKIVTDEIGAKYYRPEMPNASEAFIDCLADVVLKKQEEVL
>Mature_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLQDLTERYRAIGGISPLAAITLEQAKRLEQRLNEMQDDVEFH
MYLGLKHIEPFIEDAVQAMHRDGIKEAIALVLAPHYSTFSVKSYIGRAQEEAAKCEDLTIHGIESWYKEPKFIQYWVDAV
KSIYDGMPEEEREKAVLIVSAHSLPEKIIALGDPYPEQLSETAEYIARGAEVPNYAVGWQSAGNTPDPWIGPDVQDLTKE
LYEKYGYTSFVYAPVGFVAEHLEVLYDNDIECKIVTDEIGAKYYRPEMPNASEAFIDCLADVVLKKQEEVL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=32.3420074349442, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=32.3420074349442, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324750, Length=282, Percent_Identity=28.3687943262411, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=26.865671641791, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI45552018, Length=181, Percent_Identity=32.5966850828729, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=23.4375, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35522; Mature: 35522

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLQDLTERYRAIGGISPLAAITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKRLEQRLNEMQDDVEFHMYLGLKHIEPFIEDAVQAMHRDGIKEAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VKSYIGRAQEEAAKCEDLTIHGIESWYKEPKFIQYWVDAVKSIYDGMPEEEREKAVLIVS
HHHHHHHHHHHHHHHHCCEEECHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHCCEEEEEE
AHSLPEKIIALGDPYPEQLSETAEYIARGAEVPNYAVGWQSAGNTPDPWIGPDVQDLTKE
CCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHH
LYEKYGYTSFVYAPVGFVAEHLEVLYDNDIECKIVTDEIGAKYYRPEMPNASEAFIDCLA
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCHHCCCCCCCHHHHHHHHHH
DVVLKKQEEVL
HHHHHHHHCCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLQDLTERYRAIGGISPLAAITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKRLEQRLNEMQDDVEFHMYLGLKHIEPFIEDAVQAMHRDGIKEAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VKSYIGRAQEEAAKCEDLTIHGIESWYKEPKFIQYWVDAVKSIYDGMPEEEREKAVLIVS
HHHHHHHHHHHHHHHHCCEEECHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHCCEEEEEE
AHSLPEKIIALGDPYPEQLSETAEYIARGAEVPNYAVGWQSAGNTPDPWIGPDVQDLTKE
CCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHH
LYEKYGYTSFVYAPVGFVAEHLEVLYDNDIECKIVTDEIGAKYYRPEMPNASEAFIDCLA
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCHHCCCCCCCHHHHHHHHHH
DVVLKKQEEVL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]