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The map label for this gene is hemE [H]

Identifier: 152974638

GI number: 152974638

Start: 939190

End: 940263

Strand: Direct

Name: hemE [H]

Synonym: Bcer98_0824

Alternate gene names: 152974638

Gene position: 939190-940263 (Clockwise)

Preceding gene: 152974637

Following gene: 152974639

Centisome position: 22.98

GC content: 39.48

Gene sequence:

>1074_bases
GTGTTCGTGAGGAAGGGAGAAAGGGTTTTGGTAAGAAATATAAATGAGACGTTTTTAAAAGCATGTAAAGGGGAACGAAC
CGATTATGTACCGGCGTGGTATATGAGACAAGCAGGGCGTTCTCAACCAGAATATAGAAAGATTAAAGAAAAGTATTCTT
TATTTGAAATTACACACAACCCGGAGCTTTGTGCCTATGTAACAAAACTTCCAGTTGATCAATACAATGTCGATGCGGCG
ATTCTATATAAAGATATTATGTCACCGCTTCCAGCAATTGGTGTTGATGTAGAAATAAAATCTGGAATTGGACCAGTAAT
CGAGAATCCAATTCGTTCTATGCAAGATGTAGAGAAGCTTGGTGAAATTCATCCAGAAGAAGATGTACCATATATATTAG
ATACCATTCGATTGTTAACAGCAGAAATGTTGGATGTTCCGCTTATCGGTTTTTCAGGTGCACCATTTACATTAGCAAGT
TATATGATTGAAGGCGGTCCGTCTCGCAACTACCATAAAACAAAAGCGTTTATGTATGCAGAACCAAAAGCTTGGTTTGC
ATTAATGGATAAGCTTTCAGATATGGTCATTGCGTATTTGAAAGCACAAATTCAGGCTGGGGCAAAGGCAGTACAAGTGT
TTGATTCTTGGGTTGGTACAGTGAATGTAGCAGATTATCGCATATTTATTAAACCAGCAATGGAGCGTATTTTTGCACAG
GTTCGTGAAATGAACGTACCGATGATCATGCACGGTGTTGGAGCAGGTCACTTAGCAAACGAATGGAATGACTTGCCGCT
TGATGTAGTAGGATTAGATTGGCGCTTGTCAATTGAAGAGGCGCGTACGCGCGGTATTCATAAAGCAGTACAAGGTAATA
TGGATCCTTCGCTATTACTTGCACCATGGAATGTCATTGAAGAGCATGTAAAAGGCATTTTAGACCAAGGAATGAAACAA
CCTGGCTATGTCTTTAATTTAGGTCACGGTGTATTTCCAGAGGTGAATCCTGATACGTTAAAACGTTTAACAGCGTTTAT
TCATGAATATTCGAAAGAGCAGTTAGCGAAGTAA

Upstream 100 bases:

>100_bases
ATTTGTGTCAATTTCATGAACAACATACATAATGTTATGCATTTTGTTTTTACAAGCTGTATAGTAAAAAAAGATAATTA
TCGAATAGGATTCGTTTGAA

Downstream 100 bases:

>100_bases
AGGAGAATTAGGGGTATGAAAAAGAAAATTGGTTTGCTTGTTATGGCATACGGAACACCATATAAAGAAGAGGATATTGA
ACGTTACTATACGCATATTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MFVRKGERVLVRNINETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAA
ILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKLGEIHPEEDVPYILDTIRLLTAEMLDVPLIGFSGAPFTLAS
YMIEGGPSRNYHKTKAFMYAEPKAWFALMDKLSDMVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQ
VREMNVPMIMHGVGAGHLANEWNDLPLDVVGLDWRLSIEEARTRGIHKAVQGNMDPSLLLAPWNVIEEHVKGILDQGMKQ
PGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK

Sequences:

>Translated_357_residues
MFVRKGERVLVRNINETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAA
ILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKLGEIHPEEDVPYILDTIRLLTAEMLDVPLIGFSGAPFTLAS
YMIEGGPSRNYHKTKAFMYAEPKAWFALMDKLSDMVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQ
VREMNVPMIMHGVGAGHLANEWNDLPLDVVGLDWRLSIEEARTRGIHKAVQGNMDPSLLLAPWNVIEEHVKGILDQGMKQ
PGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK
>Mature_357_residues
MFVRKGERVLVRNINETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAA
ILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKLGEIHPEEDVPYILDTIRLLTAEMLDVPLIGFSGAPFTLAS
YMIEGGPSRNYHKTKAFMYAEPKAWFALMDKLSDMVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQ
VREMNVPMIMHGVGAGHLANEWNDLPLDVVGLDWRLSIEEARTRGIHKAVQGNMDPSLLLAPWNVIEEHVKGILDQGMKQ
PGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=36.7521367521368, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=39.8843930635838, Blast_Score=247, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=31.8051575931232, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=33.4302325581395, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=33.4302325581395, Blast_Score=208, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40410; Mature: 40410

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVRKGERVLVRNINETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHN
CCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHEEEECC
PELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKL
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHH
GEIHPEEDVPYILDTIRLLTAEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHKTKAFMYA
HCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCCCCHHHEEEEE
EPKAWFALMDKLSDMVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHH
VREMNVPMIMHGVGAGHLANEWNDLPLDVVGLDWRLSIEEARTRGIHKAVQGNMDPSLLL
HHHCCCCEEEEECCCCHHCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHCCCCCCEEE
APWNVIEEHVKGILDQGMKQPGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFVRKGERVLVRNINETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHN
CCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHEEEECC
PELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKL
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHH
GEIHPEEDVPYILDTIRLLTAEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHKTKAFMYA
HCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCCCCHHHEEEEE
EPKAWFALMDKLSDMVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHH
VREMNVPMIMHGVGAGHLANEWNDLPLDVVGLDWRLSIEEARTRGIHKAVQGNMDPSLLL
HHHCCCCEEEEECCCCHHCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHCCCCCCEEE
APWNVIEEHVKGILDQGMKQPGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA