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The map label for this gene is adhA [H]

Identifier: 152974586

GI number: 152974586

Start: 881687

End: 882712

Strand: Direct

Name: adhA [H]

Synonym: Bcer98_0768

Alternate gene names: 152974586

Gene position: 881687-882712 (Clockwise)

Preceding gene: 152974585

Following gene: 152974590

Centisome position: 21.57

GC content: 40.25

Gene sequence:

>1026_bases
ATGAAAGCAGTAGTGGTTAATAAAAACAGCAAAGCAAACATTGAAGTTATCGAAAAAGAATTACGTCCGTTACGCGCAGG
CGAAGCGTTAGTAGATGTAGAATATTGCGGAGTTTGTCATACTGACTTACACGTTGCAAATCATGACTTTGGTAACACAG
ATGGTCGTATTCTTGGACACGAGGGCATAGGAATTGTAACGAAAATTGCAGATGATGTTACTTCGCTTCAGGTTGGTGAC
CGTGTAAGTATCGCATGGATGTTCCAATCTTGTGGTCGTTGTGAATATTGCGTAACTGGTAGAGAAACATTTTGTCGTGA
AGTTAAGAATGCGGGTTATACAGTAGATGGCGGTATGGCTGAACAATGTATCGTTACTGCTGATTATGCGGTAAAAGTAC
CAGAAGGATTAGATCCTGCTCAAGCATCATCTATCACATGTGCCGGTGTAACTACATATAAAGCGATTAAAGTATCCGAT
ATTAAACCTGGCCAATCTATCGTAATCTACGGTTGTGGTGGATTAGGTAACCTTGCTGTCCAATATGCGAAACATGTATT
TGGTGCAAAGGTTATTGCAGTAGATATCAATGACGACAAATTAGCATTGGCTAAAAAGGTTGGTGCTGATATGACAATCA
ATCCAACTACTCAAGGACTTGCTGATAAGATAATTCAAGAGGCATTTGGTGGTGCTTATGCTGCTGTAGTAACAGCAGTT
TCTAAAGTGGCCTTCAACTCAGCAGTTGATGCAGTCCGTGCTTGCGGTAAAGTCGTTGCGGTAGGTTTACCAGTAGAAAC
TATGGATTTAAGCATTCCACGACTTGTGTTAGATGGAATTGAAGTAGTAGGTTCTTTAGTTGGTACTCGTAAGGACTTAG
AAGAAGCATTTATGTTCGGTGCAGAAGGCAAAGTAGTGCCGGTTGTTCAAACTTGTTCATTAGATGAAGTACAAGATGTA
TTCGAAGAAATGGAGCAAGGTAAGATTCAAGGTCGTATGGTAATCGATTTTAAACAGCATAAGTAA

Upstream 100 bases:

>100_bases
TGTAGCCCTTACATTTGGGACAAGTATTGGTTATAGCGGTGTAGATAAAAGTTGTTAGATGGACGCATTGAAATTCTAAA
ATATGAAAGGAAGATCGCAT

Downstream 100 bases:

>100_bases
TTGCTAGTGTAAACAAATTTATTTTGTTTTCACGATTGTTGGTGCGGTTCTCTTAGTAAATATGAAAATGGGATCAGTCC
AGTATGAAATGAAGTCACTA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAVVVNKNSKANIEVIEKELRPLRAGEALVDVEYCGVCHTDLHVANHDFGNTDGRILGHEGIGIVTKIADDVTSLQVGD
RVSIAWMFQSCGRCEYCVTGRETFCREVKNAGYTVDGGMAEQCIVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSD
IKPGQSIVIYGCGGLGNLAVQYAKHVFGAKVIAVDINDDKLALAKKVGADMTINPTTQGLADKIIQEAFGGAYAAVVTAV
SKVAFNSAVDAVRACGKVVAVGLPVETMDLSIPRLVLDGIEVVGSLVGTRKDLEEAFMFGAEGKVVPVVQTCSLDEVQDV
FEEMEQGKIQGRMVIDFKQHK

Sequences:

>Translated_341_residues
MKAVVVNKNSKANIEVIEKELRPLRAGEALVDVEYCGVCHTDLHVANHDFGNTDGRILGHEGIGIVTKIADDVTSLQVGD
RVSIAWMFQSCGRCEYCVTGRETFCREVKNAGYTVDGGMAEQCIVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSD
IKPGQSIVIYGCGGLGNLAVQYAKHVFGAKVIAVDINDDKLALAKKVGADMTINPTTQGLADKIIQEAFGGAYAAVVTAV
SKVAFNSAVDAVRACGKVVAVGLPVETMDLSIPRLVLDGIEVVGSLVGTRKDLEEAFMFGAEGKVVPVVQTCSLDEVQDV
FEEMEQGKIQGRMVIDFKQHK
>Mature_341_residues
MKAVVVNKNSKANIEVIEKELRPLRAGEALVDVEYCGVCHTDLHVANHDFGNTDGRILGHEGIGIVTKIADDVTSLQVGD
RVSIAWMFQSCGRCEYCVTGRETFCREVKNAGYTVDGGMAEQCIVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSD
IKPGQSIVIYGCGGLGNLAVQYAKHVFGAKVIAVDINDDKLALAKKVGADMTINPTTQGLADKIIQEAFGGAYAAVVTAV
SKVAFNSAVDAVRACGKVVAVGLPVETMDLSIPRLVLDGIEVVGSLVGTRKDLEEAFMFGAEGKVVPVVQTCSLDEVQDV
FEEMEQGKIQGRMVIDFKQHK

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=27.9005524861878, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=28.1767955801105, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4501929, Length=313, Percent_Identity=30.6709265175719, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI71565154, Length=225, Percent_Identity=29.7777777777778, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI262073058, Length=321, Percent_Identity=25.8566978193146, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71743840, Length=321, Percent_Identity=25.8566978193146, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI71565152, Length=348, Percent_Identity=25, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.7617728531856, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=25.7617728531856, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156627571, Length=265, Percent_Identity=23.0188679245283, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=67.551622418879, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI87082401, Length=336, Percent_Identity=27.0833333333333, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790045, Length=324, Percent_Identity=24.3827160493827, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786518, Length=343, Percent_Identity=26.2390670553936, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786552, Length=351, Percent_Identity=29.3447293447293, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788073, Length=271, Percent_Identity=28.7822878228782, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=325, Percent_Identity=26.1538461538462, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=25.8258258258258, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=25.6410256410256, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790718, Length=288, Percent_Identity=26.3888888888889, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788407, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786825, Length=216, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=315, Percent_Identity=36.1904761904762, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=35.8662613981763, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=36.5079365079365, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17562876, Length=255, Percent_Identity=30.9803921568627, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=192, Percent_Identity=31.7708333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=242, Percent_Identity=28.5123966942149, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=23.1884057971014, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=38.801261829653, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=35.9050445103858, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=37.2239747634069, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6319621, Length=317, Percent_Identity=36.5930599369085, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319949, Length=355, Percent_Identity=28.169014084507, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323980, Length=334, Percent_Identity=26.0479041916168, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=26.9972451790634, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=290, Percent_Identity=25.1724137931034, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=286, Percent_Identity=28.3216783216783, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=286, Percent_Identity=27.972027972028, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=256, Percent_Identity=28.90625, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=331, Percent_Identity=24.773413897281, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=229, Percent_Identity=27.9475982532751, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737895, Length=228, Percent_Identity=30.2631578947368, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737897, Length=208, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36275; Mature: 36275

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNKNSKANIEVIEKELRPLRAGEALVDVEYCGVCHTDLHVANHDFGNTDGRILGH
CCEEEECCCCCCCHHHHHHHHCCHHCCCEEEEEHHCCEECCCEEEECCCCCCCCCEEEEC
EGIGIVTKIADDVTSLQVGDRVSIAWMFQSCGRCEYCVTGRETFCREVKNAGYTVDGGMA
CCCEEEHHHHHHHHHEECCCCEEEEEEHHHCCCCEEEECCHHHHHHHHHHCCEEECCCCC
EQCIVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSDIKPGQSIVIYGCGGLGNLAV
CCEEEEECEEEECCCCCCCCCCCCEEEECEEEEEEEEEECCCCCCEEEEEECCCHHHHHH
QYAKHVFGAKVIAVDINDDKLALAKKVGADMTINPTTQGLADKIIQEAFGGAYAAVVTAV
HHHHHHHCCEEEEEEECCCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHH
SKVAFNSAVDAVRACGKVVAVGLPVETMDLSIPRLVLDGIEVVGSLVGTRKDLEEAFMFG
HHHHHHHHHHHHHHCCCEEEECCCEEHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGKVVPVVQTCSLDEVQDVFEEMEQGKIQGRMVIDFKQHK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKAVVVNKNSKANIEVIEKELRPLRAGEALVDVEYCGVCHTDLHVANHDFGNTDGRILGH
CCEEEECCCCCCCHHHHHHHHCCHHCCCEEEEEHHCCEECCCEEEECCCCCCCCCEEEEC
EGIGIVTKIADDVTSLQVGDRVSIAWMFQSCGRCEYCVTGRETFCREVKNAGYTVDGGMA
CCCEEEHHHHHHHHHEECCCCEEEEEEHHHCCCCEEEECCHHHHHHHHHHCCEEECCCCC
EQCIVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSDIKPGQSIVIYGCGGLGNLAV
CCEEEEECEEEECCCCCCCCCCCCEEEECEEEEEEEEEECCCCCCEEEEEECCCHHHHHH
QYAKHVFGAKVIAVDINDDKLALAKKVGADMTINPTTQGLADKIIQEAFGGAYAAVVTAV
HHHHHHHCCEEEEEEECCCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHH
SKVAFNSAVDAVRACGKVVAVGLPVETMDLSIPRLVLDGIEVVGSLVGTRKDLEEAFMFG
HHHHHHHHHHHHHHCCCEEEECCCEEHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGKVVPVVQTCSLDEVQDVFEEMEQGKIQGRMVIDFKQHK
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]