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The map label for this gene is npr [H]

Identifier: 152974346

GI number: 152974346

Start: 590016

End: 591713

Strand: Direct

Name: npr [H]

Synonym: Bcer98_0515

Alternate gene names: 152974346

Gene position: 590016-591713 (Clockwise)

Preceding gene: 152974345

Following gene: 152974348

Centisome position: 14.44

GC content: 37.34

Gene sequence:

>1698_bases
ATGAAAAAGAAGAGTTTAGCTTTTGTATTAGCAGCAGGGATGGCTGTGACGACATTTGGAGGGACGAGCTCTGCGTTTGC
AGATTCAAAGAATGTGCTCTCTACGAAAAAGTACAATGAAGCCGTTAAATCGCCAGAGTTTGTAGCAGGTGATTTGACTG
GAGCGACTGGAAAGAAAGCAGAATCTGTCGTGTTTGATTATTTAAATGCGGCCAAAGGGGACTATAAGTTAGGAAATAAA
AATGCCGAAGATTCTTTTAAAATTAAAGAAGTGAAAAAGGATTCGGTAACAGATTCGACAGTCGTACGTATGCAACAAGT
ATTTGAAGGGACACCTGTATGGGGGTCTACTCAAGTGGCTCACGTAAGTAAAGATGGCTCATTGAAGGTGTTGTCTGGAA
CGGTTGTACCAGATTTAGATAAAAAAGAGAAATTAAGAAATACGAATAAGATTGAGGAGAAAAAAGCAATTGCCATTGCT
GAACAAGACTTAGGGTTAAAACCAAAATATGAAGTAGAGCCCAAAGCTCATTTACATGTCTATCAAAATGGCGATGAAAC
AACGTATGCCTATGTTGTAAATTTAAATTTCTTAGATCCGCAACCAGGAAACTATTATTATTTTATTGAAGCAGAAAGCG
GTAAAGTATTAAATAAATACAATACATTAGATCATGTAACTGAAGAAAGTAAAGTACCGGTTAATCAAGAGTTTACAAAA
CAAGAAAAAGGAGCTATCAAACCTGTAACGGGAACGAATGCAGTTGGGACAGGTACAGGTGTATTAGGAGATAAAAAATC
AATAAATACGACATTATCTGGATCTACGTATTATTTACAAGATAATACGAGAGGGGCGCAAATTTTCACATATGATGCGA
AAAATCGTTCTTCTTTACCAGGAACGTTATGGGCAGATGTTGATAATGCATTTCATGCAAAGTATGATGCAGCAGCAGTA
GATGCTCATTATTATGCGGGCGTCACATATGATTACTATAAAAATACGTTTAATCGAAATTCTATTAACGATGCAGGAGC
TGCGCTAAAATCAACAGTTCATTATGGAAGTAATTATAATAATGCTTTCTGGAATGGTTCGCAAATGGTATATGGAGATG
GTGATGGAGTAACATTTACTTCGTTATCTGGTGGAATTGATGTAATTGGGCATGAATTGACACATGCTGTGACAGAATAT
AGTTCGAATTTAATCTATCAATATGAGTCGGGTGCATTAAACGAAGCGATTTCTGATATTTTTGGTACATTGGTAGAATA
CTATGATAATCGTAATCCAGATTGGGAAATTGGAGAAGATATTTATACACCTGGAAAAGCCGGAGATGCACTTCGCTCTA
TGAGTGATCCGACAAAGTATGGTGATCCAGATCATTATTCGAAACGCTACACTGGTTCTGGTGATAATGGTGGAGTTCAT
ACAAACAGCGGAATTATTAACAAAGCGGCTTATTTATTAGCAAATGGTGGCACACATTATGGAGTGACAGTGAATGGTAT
TGGCAAGGATAAAGTAGGAGCAATTTACTATCGTGCAAATACGCAATATTTCACGCAATCGACTACATTTAGTCAAGCTC
GTGCTGGTTTAGTACAAGCAGCAGCTGATTTATACGGCGCAAATTCTGCAGAGGTAACAGCGGTAAAACAATCATATGAC
GCAGTTGGAGTAAAATAA

Upstream 100 bases:

>100_bases
GAGAAAGTAATTATTTGATTTTTTTGTATATTCATAGCGAAAACTTAATGATAATATAAAGCTACTCTTTTTAAAAATTT
TTATTTAGGGGGAAGGTTGA

Downstream 100 bases:

>100_bases
GAAAAAATAAAAAGGAGCGATATGCTCCTTTTTATTTTTTCTTCCATTTCCTCCATATATATATGATTCCGATGCAACTA
GCAATTGTTATAATCCATTT

Product: thermolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MKKKSLAFVLAAGMAVTTFGGTSSAFADSKNVLSTKKYNEAVKSPEFVAGDLTGATGKKAESVVFDYLNAAKGDYKLGNK
NAEDSFKIKEVKKDSVTDSTVVRMQQVFEGTPVWGSTQVAHVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIA
EQDLGLKPKYEVEPKAHLHVYQNGDETTYAYVVNLNFLDPQPGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTK
QEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLPGTLWADVDNAFHAKYDAAAV
DAHYYAGVTYDYYKNTFNRNSINDAGAALKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEY
SSNLIYQYESGALNEAISDIFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSGDNGGVH
TNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGANSAEVTAVKQSYD
AVGVK

Sequences:

>Translated_565_residues
MKKKSLAFVLAAGMAVTTFGGTSSAFADSKNVLSTKKYNEAVKSPEFVAGDLTGATGKKAESVVFDYLNAAKGDYKLGNK
NAEDSFKIKEVKKDSVTDSTVVRMQQVFEGTPVWGSTQVAHVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIA
EQDLGLKPKYEVEPKAHLHVYQNGDETTYAYVVNLNFLDPQPGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTK
QEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLPGTLWADVDNAFHAKYDAAAV
DAHYYAGVTYDYYKNTFNRNSINDAGAALKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEY
SSNLIYQYESGALNEAISDIFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSGDNGGVH
TNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGANSAEVTAVKQSYD
AVGVK
>Mature_565_residues
MKKKSLAFVLAAGMAVTTFGGTSSAFADSKNVLSTKKYNEAVKSPEFVAGDLTGATGKKAESVVFDYLNAAKGDYKLGNK
NAEDSFKIKEVKKDSVTDSTVVRMQQVFEGTPVWGSTQVAHVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIA
EQDLGLKPKYEVEPKAHLHVYQNGDETTYAYVVNLNFLDPQPGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTK
QEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLPGTLWADVDNAFHAKYDAAAV
DAHYYAGVTYDYYKNTFNRNSINDAGAALKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEY
SSNLIYQYESGALNEAISDIFGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSGDNGGVH
TNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQAAADLYGANSAEVTAVKQSYD
AVGVK

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 61235; Mature: 61235

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKSLAFVLAAGMAVTTFGGTSSAFADSKNVLSTKKYNEAVKSPEFVAGDLTGATGKKA
CCCHHEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHH
ESVVFDYLNAAKGDYKLGNKNAEDSFKIKEVKKDSVTDSTVVRMQQVFEGTPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIAEQDLGLKPKYEVEPKAHLHV
EECCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHEEEEEHHCCCCCCCEECCCCEEEEE
YQNGDETTYAYVVNLNFLDPQPGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCEEHHHCHHHHHCCCCCCCCCHHHHH
QEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLP
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCC
GTLWADVDNAFHAKYDAAAVDAHYYAGVTYDYYKNTFNRNSINDAGAALKSTVHYGSNYN
CEEEECCCCHHHCCCCCEEECCEEEECCEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
NAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSNLIYQYESGALNEAISDI
CCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
FGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSGDNGGVH
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
TNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQA
CCCCCHHCEEEEEECCCEEEEEEEECCCCCCCEEEEEEECCEEEEECCCHHHHHHHHHHH
AADLYGANSAEVTAVKQSYDAVGVK
HHHHHCCCCCEEEEEHHCCCCCCCC
>Mature Secondary Structure
MKKKSLAFVLAAGMAVTTFGGTSSAFADSKNVLSTKKYNEAVKSPEFVAGDLTGATGKKA
CCCHHEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHH
ESVVFDYLNAAKGDYKLGNKNAEDSFKIKEVKKDSVTDSTVVRMQQVFEGTPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVVPDLDKKEKLRNTNKIEEKKAIAIAEQDLGLKPKYEVEPKAHLHV
EECCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHEEEEEHHCCCCCCCEECCCCEEEEE
YQNGDETTYAYVVNLNFLDPQPGNYYYFIEAESGKVLNKYNTLDHVTEESKVPVNQEFTK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCEEHHHCHHHHHCCCCCCCCCHHHHH
QEKGAIKPVTGTNAVGTGTGVLGDKKSINTTLSGSTYYLQDNTRGAQIFTYDAKNRSSLP
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCC
GTLWADVDNAFHAKYDAAAVDAHYYAGVTYDYYKNTFNRNSINDAGAALKSTVHYGSNYN
CEEEECCCCHHHCCCCCEEECCEEEECCEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
NAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTEYSSNLIYQYESGALNEAISDI
CCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
FGTLVEYYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSGDNGGVH
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
TNSGIINKAAYLLANGGTHYGVTVNGIGKDKVGAIYYRANTQYFTQSTTFSQARAGLVQA
CCCCCHHCEEEEEECCCEEEEEEEECCCCCCCEEEEEEECCEEEEECCCHHHHHHHHHHH
AADLYGANSAEVTAVKQSYDAVGVK
HHHHHCCCCCEEEEEHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1495388; 3092843; 3127592; 1633827 [H]