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The map label for this gene is gabT [H]

Identifier: 152974144

GI number: 152974144

Start: 347144

End: 348508

Strand: Direct

Name: gabT [H]

Synonym: Bcer98_0303

Alternate gene names: 152974144

Gene position: 347144-348508 (Clockwise)

Preceding gene: 152974143

Following gene: 152974145

Centisome position: 8.49

GC content: 38.1

Gene sequence:

>1365_bases
ATGAGTATAAAAAAATATGCAAAAGTAAATGAGCAAATTCCAGGGCCAAAAGCAGCTTCTTTATTAGAACGTCGTCAAAA
TATTATACCAAGAGGTGTGAGTAATGGGATTTCAACGTTTGTACAATCAGCAGATGGAGCACTTGTAACAGATGTCGATG
GAAATCAATTCATTGATTTTGCAGGTGCGATTGGAACGATTAATGTAGGGCATTGTCATCCAGCAGTAACAGAAGCGCTT
CATAAACAAGTAGATCAATATATTCATACTGGCTTTAATGTTATGATGTATGAACCGTATATTGAGCTAGCAGAGAAATT
AGCTAGATTAGCACCAGGAAATTTTGATAAGCAAGTATTATTTTTAAATAGCGGTGCGGAAGCAGTTGAAAATGCAGTGA
AGATTGCTCGTAAATATACGAGAAGATCTGGTATCATTGCATTTTCAAAAGGATTTCATGGTCGCACATTAATGACAATG
ACGATGACAAGTAAAGTGAAACCGTATAAATTTGGCTTTGGACCATTTGCCCCTGAAGTATATAAAGCGCCGTTTCCATA
TGAGTATCGCCGTCCAGAAGGGTTAACAGATGAGCAATATGATAACTTTATGATTGAAGAATTGAAGAACTTCTTCCTAT
CAGAAGTAGCTCCAGAAAGCATAGCTGCTGTTGTAATGGAACCTGTTCAAGGTGAGGGTGGTTTTATCGTTCCAAGTAAA
AAGTTTGTTCAAGAAGTACGTCGTCTTTGCTCGGAATATGACATTTTATTTGTAGCTGATGAAATTCAAACAGGATTTAG
CCGGACAGGAAAATATTTTGCAATTGATCATTACGATGTTGTACCAGATTTAATTACGGTTTCTAAGTCACTAGGGGCTG
GAGTACCAATTAGTGGAGTTATTGGTCGTAAGGAGATAATGAATGAGGCAGCACCAGGCGAGCTTGGAGGAACGTACGCG
GGAAGTCCACTTGGCTGCGTAGCCGCATTAGCTGTTTTAGATATTATTGAGAAAGAAAAGTTAAATGATCGAGCTATGCA
TATTGGGAAAATTGTGATGGAACGATTTGAAGAGATGAAGAAGAAATATCATTGTATTGGTCATGTTCGTGGATTAGGGG
CAATGTGTGCATTTGAGCTTGTGAAAGATCGCAGTACGAAAGAGCCTGATAAAGCTTTAACTGCAAACTTATGTGCTGAA
GCGAATAAACGTGGCTTGCTTTTATTATCAGCGGGAACTTATGGAAATGTCATTCGTGTTCTTATGCCGCTCATTATTAC
AGATGAGCAATTGGAAGAAGGGCTTACAATTATTGAAGAATCTTTACAATCTTGTTATACACAAGCAAATATGGCTCGGG
TATAA

Upstream 100 bases:

>100_bases
AAATATAAAGAAAAAGGGAAGAATGCTAGGATCATAAGTTGGCATACATTTTGCAATGGATATAAGAAAAAACATTGTAT
AGAAAAGGATGGGAAAAACG

Downstream 100 bases:

>100_bases
AGGGTGGATGTACCGATAACACAGTTGCAATTATTCTAGTTTACCGCCTTAAAAATACAGAAAATTCCCTTAAATTAAGT
TTTAGATTTATAATAGAATA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSIKKYAKVNEQIPGPKAASLLERRQNIIPRGVSNGISTFVQSADGALVTDVDGNQFIDFAGAIGTINVGHCHPAVTEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLARLAPGNFDKQVLFLNSGAEAVENAVKIARKYTRRSGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTDEQYDNFMIEELKNFFLSEVAPESIAAVVMEPVQGEGGFIVPSK
KFVQEVRRLCSEYDILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNEAAPGELGGTYA
GSPLGCVAALAVLDIIEKEKLNDRAMHIGKIVMERFEEMKKKYHCIGHVRGLGAMCAFELVKDRSTKEPDKALTANLCAE
ANKRGLLLLSAGTYGNVIRVLMPLIITDEQLEEGLTIIEESLQSCYTQANMARV

Sequences:

>Translated_454_residues
MSIKKYAKVNEQIPGPKAASLLERRQNIIPRGVSNGISTFVQSADGALVTDVDGNQFIDFAGAIGTINVGHCHPAVTEAL
HKQVDQYIHTGFNVMMYEPYIELAEKLARLAPGNFDKQVLFLNSGAEAVENAVKIARKYTRRSGIIAFSKGFHGRTLMTM
TMTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTDEQYDNFMIEELKNFFLSEVAPESIAAVVMEPVQGEGGFIVPSK
KFVQEVRRLCSEYDILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNEAAPGELGGTYA
GSPLGCVAALAVLDIIEKEKLNDRAMHIGKIVMERFEEMKKKYHCIGHVRGLGAMCAFELVKDRSTKEPDKALTANLCAE
ANKRGLLLLSAGTYGNVIRVLMPLIITDEQLEEGLTIIEESLQSCYTQANMARV
>Mature_453_residues
SIKKYAKVNEQIPGPKAASLLERRQNIIPRGVSNGISTFVQSADGALVTDVDGNQFIDFAGAIGTINVGHCHPAVTEALH
KQVDQYIHTGFNVMMYEPYIELAEKLARLAPGNFDKQVLFLNSGAEAVENAVKIARKYTRRSGIIAFSKGFHGRTLMTMT
MTSKVKPYKFGFGPFAPEVYKAPFPYEYRRPEGLTDEQYDNFMIEELKNFFLSEVAPESIAAVVMEPVQGEGGFIVPSKK
FVQEVRRLCSEYDILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGVIGRKEIMNEAAPGELGGTYAG
SPLGCVAALAVLDIIEKEKLNDRAMHIGKIVMERFEEMKKKYHCIGHVRGLGAMCAFELVKDRSTKEPDKALTANLCAEA
NKRGLLLLSAGTYGNVIRVLMPLIITDEQLEEGLTIIEESLQSCYTQANMARV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=34.375, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI13994255, Length=412, Percent_Identity=31.0679611650485, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI24119277, Length=453, Percent_Identity=30.242825607064, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI37574042, Length=407, Percent_Identity=30.958230958231, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI284507298, Length=332, Percent_Identity=34.6385542168675, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=31.1053984575836, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI226442705, Length=407, Percent_Identity=30.2211302211302, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=24.8394004282655, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=24.8394004282655, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=24.8394004282655, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=45.9207459207459, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=47.3809523809524, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=34.0050377833753, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789759, Length=396, Percent_Identity=33.3333333333333, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI145693181, Length=424, Percent_Identity=32.7830188679245, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786349, Length=373, Percent_Identity=30.0268096514745, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=28.9473684210526, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=446, Percent_Identity=32.0627802690583, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=31.3868613138686, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32564660, Length=412, Percent_Identity=31.5533980582524, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=298, Percent_Identity=31.2080536912752, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17541228, Length=469, Percent_Identity=22.3880597014925, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=157, Percent_Identity=30.5732484076433, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=32.289156626506, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=31.4009661835749, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6321456, Length=401, Percent_Identity=25.1870324189526, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=487, Percent_Identity=25.2566735112936, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=33.1719128329298, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=30.4250559284116, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=30.8584686774942, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI21356575, Length=412, Percent_Identity=30.5825242718447, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI281366494, Length=424, Percent_Identity=26.1792452830189, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667139, Length=424, Percent_Identity=26.1792452830189, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667143, Length=424, Percent_Identity=26.1792452830189, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 50044; Mature: 49913

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKYAKVNEQIPGPKAASLLERRQNIIPRGVSNGISTFVQSADGALVTDVDGNQFIDF
CCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEC
AGAIGTINVGHCHPAVTEALHKQVDQYIHTGFNVMMYEPYIELAEKLARLAPGNFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTRRSGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRRPEGLTDEQYDNFMIEELKNFFLSEVAPESIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFVQEVRRLCSEYDILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHC
IGRKEIMNEAAPGELGGTYAGSPLGCVAALAVLDIIEKEKLNDRAMHIGKIVMERFEEMK
CCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
KKYHCIGHVRGLGAMCAFELVKDRSTKEPDKALTANLCAEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLIITDEQLEEGLTIIEESLQSCYTQANMARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIKKYAKVNEQIPGPKAASLLERRQNIIPRGVSNGISTFVQSADGALVTDVDGNQFIDF
CCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEC
AGAIGTINVGHCHPAVTEALHKQVDQYIHTGFNVMMYEPYIELAEKLARLAPGNFDKQVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCEEE
FLNSGAEAVENAVKIARKYTRRSGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEV
EECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
YKAPFPYEYRRPEGLTDEQYDNFMIEELKNFFLSEVAPESIAAVVMEPVQGEGGFIVPSK
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCH
KFVQEVRRLCSEYDILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVPISGV
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHC
IGRKEIMNEAAPGELGGTYAGSPLGCVAALAVLDIIEKEKLNDRAMHIGKIVMERFEEMK
CCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
KKYHCIGHVRGLGAMCAFELVKDRSTKEPDKALTANLCAEANKRGLLLLSAGTYGNVIRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
LMPLIITDEQLEEGLTIIEESLQSCYTQANMARV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]