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The map label for this gene is groEL [H]

Identifier: 152974096

GI number: 152974096

Start: 269274

End: 270902

Strand: Direct

Name: groEL [H]

Synonym: Bcer98_0252

Alternate gene names: 152974096

Gene position: 269274-270902 (Clockwise)

Preceding gene: 152974095

Following gene: 152974097

Centisome position: 6.59

GC content: 40.76

Gene sequence:

>1629_bases
ATGGCAAAAGATATTAAATTTAGTGAAGAAGCACGTCGTTCGATGCTTCGCGGTGTCGACACTCTTGCAAACGCAGTAAA
AGTAACACTTGGACCAAAAGGTCGCAACGTTGTACTTGAGAAAAAATTTGGTTCACCACTTATTACAAATGACGGTGTAA
CAATCGCAAAAGAAATTGAATTAGAAGATGCTTTTGAAAACATGGGTGCAAAATTAGTAGCAGAAGTTGCTAGCAAAACA
AATGATGTAGCTGGTGACGGAACAACAACTGCAACTGTATTAGCACAAGCTATGATTCGTGAAGGTTTGAAAAACGTAAC
AGCTGGTGCAAACCCAATGGGTCTTCGCAAAGGTATTGAAAAAGCTGTTGCTACAGCAGTAGAAGAGTTAAAAACAATTT
CTAAGCCAATTGAAGGTAAATCTTCTATCGCACAAGTAGCGGCTATTTCTGCTGCTGACGAAGAAGTAGGTCAATTAATT
GCAGAAGCGATGGAACGCGTTGGTAATGATGGCGTTATTACATTAGAAGAATCTAAAGGATTCACAACAGAATTAGATGT
AGTAGAAGGTATGCAATTTGATCGTGGATATGCATCTCCTTACATGATTACTGATTCTGACAAAATGGAAGCAGTTCTTG
ATAACCCATATATCTTAATTACTGACAAAAAGATTTCTAACATTCAAGAGATCTTACCAGTGTTAGAACAAGTGGTACAA
CAAGGTAAACCACTTCTTATTATCGCTGAAGATGTAGAAGGTGAAGCGTTAGCTACATTAGTAGTAAACAAACTTCGCGG
TACATTCAATGTAGTAGCTGTTAAAGCTCCAGGATTTGGTGACCGTCGTAAAGCAATGTTAGAAGATATCGCAATCTTAA
CGGATGGCGAAGTAATCACTGAAGAACTAGGCCGCGACTTAAAATCAGCTACAATTGAGTCTTTAGGACGCGCTGGTAAA
GTTGTGGTAACGAAAGAAAACACAACAATCGTAGAAGGTGTAGGAAGCACTGAACAAATCGAAGCTCGCATCGGTCAAAT
CCGTGCGCAATTAGAAGAAACAACTTCTGAATTCGATCGTGAAAAATTACAAGAACGTCTTGCTAAACTTGCAGGTGGCG
TTGCAGTAATTAAAGTAGGTGCAGCAACTGAAACTGAGTTAAAAGAACGTAAACTTCGCATTGAAGATGCACTTAACTCA
ACTCGTGCAGCAGTAGAAGAAGGTATTGTTGCAGGTGGCGGTACTTCACTTATGAATGTATACGCTAAAGTAGCTTCTAT
TGCAGCTGAAGGCGACGAAGCAACAGGTATCAACATTGTACTTCGTGCATTAGAAGAGCCAGTTCGCCAAATCGCAATCA
ACGCTGGTCTAGAAGGATCTGTAGTGGTAGAACGTCTAAAAGGCGAAAAAGTAGGTGTTGGTTTCAACGCAGCAACAGGC
GAATGGGTAAACATGCTTGAGTCTGGTATCGTAGACCCAGCAAAAGTAACTCGTTCTGCACTTCAAAACGCAGCATCTGT
TGCAGCAATGTTCTTAACAACAGAAGCAGTAGTAGCTGACAAACCAGAAGAAAATAAACCGGCAATGCCAGACATGGGTG
CAATGGGCGGCATGCCAGGAATGATGTAA

Upstream 100 bases:

>100_bases
GTGAAATATGAAGGTACAGACTACTTGATTTTACGCGAAAGTGACATTTTAGCAGTTATCGGTTAATTATATATTTAAAA
AATCCAAGGGGGTCAATATT

Downstream 100 bases:

>100_bases
TTTCATTATTCGCTAAAACACTCATCTCTTTTCGAGAGATGGGTGTTTTTTGTTATCAAATTTCTCGAAATTATAGTAAA
AAAGGTTTTATCGTAACCGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVATAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTDGEVITEELGRDLKSATIESLGRAGK
VVVTKENTTIVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYAKVASIAAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEENKPAMPDMGAMGGMPGMM

Sequences:

>Translated_542_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVATAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTDGEVITEELGRDLKSATIESLGRAGK
VVVTKENTTIVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYAKVASIAAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEENKPAMPDMGAMGGMPGMM
>Mature_541_residues
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTN
DVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVATAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIA
EAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQQ
GKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTDGEVITEELGRDLKSATIESLGRAGKV
VVTKENTTIVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNST
RAAVEEGIVAGGGTSLMNVYAKVASIAAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGE
WVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEENKPAMPDMGAMGGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=51.4177693761815, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=51.4177693761815, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI24307939, Length=228, Percent_Identity=26.7543859649123, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI63162572, Length=548, Percent_Identity=22.8102189781022, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI38455427, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=64.0684410646388, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=47.9166666666667, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193210679, Length=207, Percent_Identity=46.3768115942029, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17564182, Length=562, Percent_Identity=24.0213523131673, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147750, Length=588, Percent_Identity=24.8299319727891, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=185, Percent_Identity=30.2702702702703, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=52.8625954198473, Blast_Score=522, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322350, Length=562, Percent_Identity=24.0213523131673, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=537, Percent_Identity=22.1601489757914, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=50.5681818181818, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=50.5681818181818, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=48.6692015209125, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=48.6692015209125, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=48.6692015209125, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=42.619926199262, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=552, Percent_Identity=35.8695652173913, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI19921262, Length=552, Percent_Identity=35.8695652173913, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24645179, Length=503, Percent_Identity=24.4532803180915, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583944, Length=542, Percent_Identity=24.7232472324723, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647245, Length=142, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652903, Length=130, Percent_Identity=31.5384615384615, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57376; Mature: 57244

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVATAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTDGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHH
EELGRDLKSATIESLGRAGKVVVTKENTTIVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YAKVASIAAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEENKPAMPDMGAMGGMPG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC
>Mature Secondary Structure 
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVATAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTDGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHH
EELGRDLKSATIESLGRAGKVVVTKENTTIVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YAKVASIAAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLESGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEENKPAMPDMGAMGGMPG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA