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The map label for this gene is guaA [H]

Identifier: 152974097

GI number: 152974097

Start: 271338

End: 272876

Strand: Direct

Name: guaA [H]

Synonym: Bcer98_0253

Alternate gene names: 152974097

Gene position: 271338-272876 (Clockwise)

Preceding gene: 152974096

Following gene: 152974098

Centisome position: 6.64

GC content: 38.86

Gene sequence:

>1539_bases
TTGAAAAAACAGCACGATACGATTATCGTTTTAGACTTTGGAAGTCAGTACAACCAATTAATTGCACGTCGCATTCGTGA
GTTCGGTGTGTACAGTGAGCTTCATCCACACACAATTACTGCGGAAGAAATTAAAGCAATGAATCCAAAAGGTATCATTT
TCTCTGGTGGACCAAATAGTGTATACGGCGAAAATGCATTCCACTGTGATGAGAAAATTTTTGAGCTAGGATTACCTATT
TTTGGTATTTGTTACGGCATGCAGCTGATGACAAAACACTTTGGTGGAAAAGTAGAGCGAGCAAACCATCGTGAGTACGG
AAAAGCAGTTCTGAAAGTAGAGAATGAATCAAAATTATATACAAACCTGCCAGAAGAACAAGTTGTATGGATGAGCCATG
GTGACTTAGTAACAGGTTTACCAGAAGGCTTTGTAGTAGATGCAACGAGCGAATCTTGTCCAATTGCTGGTATGAGCAAT
GAAGAAAAGCAGTTATACGGTGTACAATTCCATCCAGAAGTACGTCACTCTGAGCACGGTAATGATTTAATTAAAAACTT
CGTATTCGGCGTATGCGGTTGTTCTGAAGGCTGGAACATGGAGAACTTTATTGAAGTAGAATTAGAAAAAATTCGTGAAA
CAGTTGGTGATAAAAAAGTACTATGTGCACTTAGCGGTGGTGTAGATTCTTCTGTTGTAGCTGTATTAATTCATAAAGCA
ATCGGTGATCAGTTAACATGTATTTTTGTTGACCACGGTTTACTTCGTAAAGGTGAAGCAGAAGGTGTTATGAAAACATT
TAGCGAAGGCTTCCATATGAATGTTATTAAAATCGATGCTAGAGAACGCTTCATGAAAAAGCTAAAAGGTGTAGAAGATC
CTGAACAAAAACGTAAAATTATCGGTAACGAATTCATTTATGTTTTTGATGATGAAGCTGCTAAATTAGAAGGAATAGAC
TTCTTAGCGCAAGGTACACTGTACACAGACATTATTGAAAGTGGTACAGCAACTGCGCAAACAATTAAATCTCACCATAA
CGTAGGTGGACTTCCAGAAGATATGCAGTTCAAATTAATCGAGCCTTTAAATACGTTATTTAAAGATGAAGTACGTGTAT
TAGGATCAGAACTAGGAATTCCTGATGAAATTGTATGGCGTCAACCATTCCCAGGTCCTGGACTTGGTATTCGTGTATTA
GGTGAAATTACAGAAGAAAAATTAGAAATTGTTCGTGAATCTGATGCGATTTTACGTGAGGAAATCCAAAAAGCAGGATT
AGACCGTGAAATTTGGCAATACTTCACTGCGCTTCCTGGTATGCGCAGCGTAGGTGTTATGGGTGACGAGCGTACTTACG
ATTATACAGTAGGTATCCGTGCCGTAACATCAATTGACGGTATGACAGCTGACTGGGCACGTATCCCTTGGGACGTATTA
GAGAAAATCTCTGTACGTATCGTAAACGAAGTAAAACACGTGAACCGCGTTGTATATGATATTACTTCTAAGCCACCAGC
AACGATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
ACGAGAGGTGGGGGACTGGCTTTTTTTATTATATTGGTAATGCTTTTTGCCTAATTTGGTGAAAATATTTATATACAGAA
TTAACGTTGGGGTGATTATT

Downstream 100 bases:

>100_bases
AACTATTTATTTGCAGGAAGGTCCATCTTATATATAGATGGATCTTTTTTATACGAACAAAAAAAGTTTAACTTATAAAA
TTGTTCGTTTTTAAGTTGAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGENAFHCDEKIFELGLPI
FGICYGMQLMTKHFGGKVERANHREYGKAVLKVENESKLYTNLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EEKQLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKIDARERFMKKLKGVEDPEQKRKIIGNEFIYVFDDEAAKLEGID
FLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIQKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRVVYDITSKPPATIEWE

Sequences:

>Translated_512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGENAFHCDEKIFELGLPI
FGICYGMQLMTKHFGGKVERANHREYGKAVLKVENESKLYTNLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EEKQLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKIDARERFMKKLKGVEDPEQKRKIIGNEFIYVFDDEAAKLEGID
FLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIQKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRVVYDITSKPPATIEWE
>Mature_512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGENAFHCDEKIFELGLPI
FGICYGMQLMTKHFGGKVERANHREYGKAVLKVENESKLYTNLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EEKQLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKIDARERFMKKLKGVEDPEQKRKIIGNEFIYVFDDEAAKLEGID
FLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIQKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRVVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=546, Percent_Identity=37.7289377289377, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=53.1007751937985, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1789760, Length=154, Percent_Identity=36.3636363636364, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=36.68430335097, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=36.68430335097, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=36.68430335097, Blast_Score=313, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=54.5631067961165, Blast_Score=555, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322638, Length=154, Percent_Identity=32.4675324675325, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=36.4963503649635, Blast_Score=311, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57535; Mature: 57535

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNS
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCC
VYGENAFHCDEKIFELGLPIFGICYGMQLMTKHFGGKVERANHREYGKAVLKVENESKLY
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCC
TNLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSNEEKQLYGVQFHPEVRHSEHG
CCCCCCEEEEEECCCEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
NDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKIDARERFMKKLKGVEDPEQKRKI
HCCCEEEEEECCCHHCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNEFIYVFDDEAAKLEGIDFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLI
CCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHH
EPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILRE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIQKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCHHHH
EKISVRIVNEVKHVNRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECC
>Mature Secondary Structure
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNS
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCC
VYGENAFHCDEKIFELGLPIFGICYGMQLMTKHFGGKVERANHREYGKAVLKVENESKLY
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCC
TNLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSNEEKQLYGVQFHPEVRHSEHG
CCCCCCEEEEEECCCEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
NDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKIDARERFMKKLKGVEDPEQKRKI
HCCCEEEEEECCCHHCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNEFIYVFDDEAAKLEGIDFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLI
CCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHH
EPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILRE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIQKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCHHHH
EKISVRIVNEVKHVNRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA