Click here to switch to the map view.

The map label for this gene is atoB [H]

Identifier: 152970604

GI number: 152970604

Start: 2249178

End: 2250359

Strand: Direct

Name: atoB [H]

Synonym: KPN_02055

Alternate gene names: 152970604

Gene position: 2249178-2250359 (Clockwise)

Preceding gene: 152970603

Following gene: 152970605

Centisome position: 42.32

GC content: 68.53

Gene sequence:

>1182_bases
ATGACCGATATTGCCATTGTTGCTGCAGTACGCACCCCGGTAGGCAGCTTTCACGGCGCCTTCGCCCCTCTTTCCGCCGT
CGACCTCGGCGCGGCGGTGGTGCGCGGCCTGCTTGAACGCTGCCAGCTGCCTGCCGCAGCGGTCGACGAACTAATTTTCG
GCCAGGTGCTTACCGCCGGCTGCGGGCAGAACCCGGCGCGCCAGACCGCGCTGCGGGCCGGCCTGCCGGTCGACACTCCG
GCGGTCACCGTCAATCTGGTCTGCGGCTCCGGACTGAAAGCGGTTCAGCAGGCGGTGCAGGCGATCCGCTGCGGCGACGC
CGGGATCGTTATCGCCGGCGGCCAGGAGAGCATGAGCAATGCTCCCTATCTGATGCATGGCGCCCGCGACGGCCTGCGTT
TCGGCCACGCCAGCCTGCAGGACAGCATGATCCAGGACGGCCTGTGGGACGCCTTCAACGACTACCACATGGGCATTACC
GCCGAGAACCTCGCCGACGCCTTCGACATCAGCCGCGAGCGCCAGGACGCCTTCGCCGCCAGCTCCCAGCGCAAAGCGGC
GGCTGCTATCGCCGCCGGGCGCTTTCGCGAGGAGATCGTCCCGGTCAGCGTCCCGCAGGGCAAAAAGCCGCCGCGAGTCG
TGACTGACGATGAGCAACCGCGCCCGGAGACCAGCGAGCAGCAGTTGGCCCAGCTGCGCCCGGCGTTTCGCCCGGCTGAC
GGCAGCGTCACCGCCGGGAATGCCTCGTCGCTGAACGACGGCGCCGCGGCGGTCCTGCTGATGCGCGTCGATAAAGCGCG
CGAGCTTGGGCTGCCGGTGCTGGCGCGCATTGTCAGCTCAGCGGTCGCCGGGGTCGACCCATCGGTGATGGGCATTGGCC
CGGTGAGCGCCTGCCGCCAGGCGCTGCATCGCGCCGGCTGGACGCTGGACGAGGTGGACCTTATCGAAGCCAACGAGGCT
TTTGCCGTCCAGGCGCTGGCCGTCGGTCAGCTGCTTGAGTGGGATAGCGAGAAGGTCAACGTCAACGGCGGCGCCATCGC
CCTTGGACATCCCATCGGCGCCTCCGGCTGCCGGATCCTCGTCAGCCTGGTGCATGAGATGCAGCGCCGGGGCGCCAGCA
AAGGGCTTGCCACCCTGTGCGTCGGCGGCGGCCAGGGCATCGCCATGACTCTACAACGTTAA

Upstream 100 bases:

>100_bases
GGCCCCGGGGGTCAGCCCCGACGAGGTGATACGTAAAACGGCGGGACGGCTGATCGTCGCCGACGACGTGCGCGAAATGC
GCTTCAGTTAAGGAGAGACC

Downstream 100 bases:

>100_bases
CAGGAGCCACTATGTTTACACCACGCCTGGCGGTACTCGGCGCGGGACTGATGGGCGTCGGTATCGCCTGCCATTTCGCC
CGTCACGGTCACGCCGTCCG

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDIAIVAAVRTPVGSFHGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTP
AVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGIT
AENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREEIVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALHRAGWTLDEVDLIEANEA
FAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR

Sequences:

>Translated_393_residues
MTDIAIVAAVRTPVGSFHGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTP
AVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGIT
AENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREEIVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALHRAGWTLDEVDLIEANEA
FAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
>Mature_392_residues
TDIAIVAAVRTPVGSFHGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTPA
VTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITA
ENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREEIVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPADG
SVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALHRAGWTLDEVDLIEANEAF
AVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=51.6624040920716, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.2569974554707, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=44.4162436548223, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=41.6666666666667, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.6470588235294, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=29.3367346938776, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=64.3765903307888, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=56.5989847715736, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=44.7761194029851, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=45.1127819548872, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=37.3522458628842, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=43.2911392405063, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=39.1414141414141, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=38.4020618556701, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.2977099236641, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=43.5443037974684, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=38.1074168797954, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=53.1806615776081, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=42.4936386768448, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=41.3265306122449, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40769; Mature: 40638

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIAIVAAVRTPVGSFHGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAG
CCCEEEEEEHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQTALRAGLPVDTPAVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSN
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHCCC
APYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITAENLADAFDISRERQDAFAA
CCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SSQRKAAAAIAAGRFREEIVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQ
CCEECCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ALHRAGWTLDEVDLIEANEAFAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRIL
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCHHHHHH
VSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
>Mature Secondary Structure 
TDIAIVAAVRTPVGSFHGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAG
CCEEEEEEHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQTALRAGLPVDTPAVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSN
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHCCC
APYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITAENLADAFDISRERQDAFAA
CCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SSQRKAAAAIAAGRFREEIVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQ
CCEECCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ALHRAGWTLDEVDLIEANEAFAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRIL
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCHHHHHH
VSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]