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The map label for this gene is norM [H]

Identifier: 152970553

GI number: 152970553

Start: 2196435

End: 2197808

Strand: Direct

Name: norM [H]

Synonym: KPN_02001

Alternate gene names: 152970553

Gene position: 2196435-2197808 (Clockwise)

Preceding gene: 152970551

Following gene: 152970554

Centisome position: 41.32

GC content: 60.12

Gene sequence:

>1374_bases
GTGCAGAAGTATTTCGTTGAAGCGCGTCAGTTATTAGCTCTGGCTATACCCGTCATCCTTGCGCAGGTGGCGCAGACGGC
GATGGGTTTTGTCGATACCGTAATGGCGGGTGGCTACAGCGCCACGGATATGGCCGCCGTGGCCATCGGGACCTCCATCT
GGCTGCCGGCGATCCTCTTCGGCCACGGCCTTCTGCTGGCGCTGACCCCGGTGGTGGCGCAGCTTAACGGATCCGGGCGG
CGAGAGCGTATCGCGCCGCAGGTGCGTCAGGGCTTCTGGCTGGCCGGCTTTGTCTCGGTGCTGATCATGGTCGTGCTGTG
GAACGCCGGATACATCATCAGCTCCATGCATAACATCGATCCGCTGTTGGCAGAGAAGGCGGTTGGCTACCTGCGCGCGC
TGCTGTGGGGCGCTCCGGGCTATCTGTTCTTCCAGGTCGCCCGTAACCAGTGTGAAGGGCTGGCAAAAACCAAGCCCGGG
ATGGTCATGGGCTTTATTGGATTACTGGTCAACATTCCGGTGAACTATATTTTTATCTATGGTCATTTCGGCATGCCCGA
GCTGGGCGGCGTCGGCTGCGGTGTGGCGACGGCCTCCGTTTACTGGGTGATGTTCGCCAGCATGCTGTGGTGGGTGCGCC
GGGCGCGTACGATGCGCGATATCCGCTGCGCCGAGCGCTTCAGCGGCCCTGATTTTGCCGTCCTGTTACGGCTGGTGCAG
CTGGGGCTGCCCATTGCTCTGGCGCTGTTCTTTGAAGTCACTCTGTTTGCCGTCGTCGCGCTGCTGGTCTCCCCGCTCGG
GATCATTGACGTCGCTGGTCACCAGATCGCGCTTAATTTCAGCTCGCTGATGTTCGTTCTGCCGCTGTCGCTGGCGGCGG
CGGTCACCATTCGCGTCGGCTTCCGCCTTGGCCAGGGCTCAACGATCGATGCCCAGGTTTCGGCCCGCACCGGCGTGGGC
GTGGGGGTCTGCCTGGCGGTATTTACCGCTATCTTTACCGTCCTGATGCGTAAGCAGATTGCGTTGCTGTATAACGATAA
TCCCGAGGTGGTGACGCTGGCCTCGCACCTGATGCTGCTGGCGGCTATCTATCAGATCTCCGACTCTATTCAGGTGATCG
GCAGCGGCATTCTGCGCGGCTATAAAGATACGCGGTCTATCTTTTTTATTACCTTTACCGCGTACTGGGTGCTGGGTTTG
CCAAGCGGCTATCTGCTGGCGCTGACCGATATGATTGTGCCCCGCATGGGACCTGCCGGTTTCTGGTGCGGATTTATCAT
CGGTCTGACCTCCGCCGCCATCATGATGATGCTGCGGATGCGTTTTCTGCAGCGCCAGCCTTCCAGCATCATCTTACAGC
GCGCTGCGCGCTAA

Upstream 100 bases:

>100_bases
CCTCGCTACAATAGACTGGAAATTCCTCATTTTTATCCCCTTGCTGCCAGTTACGGCGGCTTTTTTAGTCTCAAAATAAC
AACAATTCGAAGGTGTTCAC

Downstream 100 bases:

>100_bases
CTTGTCTAAGCCCGCCGCTCCGGCGGGCTTTTTCGTTCTTCGCTATAACGGCGCGTTGTACATTCCGTTACTCCCTGACA
CCAAAGACTCACTGATAGCC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGR
RERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPG
MVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ
LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVG
VGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGL
PSGYLLALTDMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR

Sequences:

>Translated_457_residues
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGR
RERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPG
MVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ
LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVG
VGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGL
PSGYLLALTDMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR
>Mature_457_residues
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGR
RERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPG
MVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ
LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVG
VGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGL
PSGYLLALTDMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR

Specific function: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=427, Percent_Identity=21.3114754098361, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI22907060, Length=433, Percent_Identity=21.2471131639723, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI38261960, Length=463, Percent_Identity=20.9503239740821, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI48994890, Length=457, Percent_Identity=87.527352297593, Blast_Score=788, Evalue=0.0,
Organism=Escherichia coli, GI226510954, Length=452, Percent_Identity=24.3362831858407, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=21.7889908256881, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321821, Length=259, Percent_Identity=21.2355212355212, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR022913 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49642; Mature: 49642

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNID
HCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCC
PLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHCCEEEEEEE
GHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVG
HCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHEE
FRLGQGSTIDAQVSARTGVGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLL
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
AAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALTDMIVPRMGPAG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
FWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNID
HCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCC
PLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHCCEEEEEEE
GHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVG
HCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHEE
FRLGQGSTIDAQVSARTGVGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLL
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
AAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALTDMIVPRMGPAG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
FWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA