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The map label for this gene is emrA [H]

Identifier: 152970327

GI number: 152970327

Start: 1956070

End: 1957113

Strand: Direct

Name: emrA [H]

Synonym: KPN_01775

Alternate gene names: 152970327

Gene position: 1956070-1957113 (Clockwise)

Preceding gene: 152970326

Following gene: 152970328

Centisome position: 36.8

GC content: 62.93

Gene sequence:

>1044_bases
ATGAATCCGGCCAGTAAGAAAAATATTCTTGTCCTGGCGGCCCTGGGCGCTGCCGCCCTGGCGGCAGCGAGCTACGGCGC
TTACTGGTGGCATACCGGGCGCTTTATGCAGACCACCGATGATGCCTATGTCGGCGGCGACATTAGCGCCATCTCCAGCA
AAGTCTCCGGCTATATCCAGCAGCTGGCGGTGCAGGACAATATGGCGGTGAAAAAAGGTGACCTGTTGATCCGCATTGAC
GACCGCGATTATCGCGCCGCCCTCGCGAAAGCCGCCGGAGAAGTGGCGGCGCAGCAGGCCGCGCTGGCCGATATCCAGGC
TACCCGCCAGCTTCAGCAGGCGACCATTACCGGCTCTGCGGCCTCGTTACTGGCCGCCACGGCGGCAACCGAAAAACTGG
CTAACGACAACCGACGCTATAACGCCCTGGCCGCGTCGAGCGCGATTTCCGCACAGATCCGCGATAACGCCTCCGCCGAT
TATCGCCGGGCGCACGCCGAGCAGGAGAAGGCCAAAGCGGATAAAACCGTGGCCGAACGTCAGCTGGCGGTGCTGGATGC
TCGCCAGCAGCAAATCCTGGCTGCCCTGGCGCAGGCCCAGGCTAACCTCGAGATTGCCAGGCTGAACCTCAGCTATACCG
ACATTCGCGCACCGTTCGATGGGGTGATTGGCAACCGCCGCGCGTGGTCCGGCTCCTTCGTCAGCAGCGGTACGCAGCTG
CTCTCCCTGGTACCCGCGCACGGCCTGTGGATTGACGCTAACTTCAAGGAAAACCAGCTGGCGCATATGCGTGCCGGCCA
GCCGGTGACCATCGTCGCCGATGTGCTGCCGAACCATACCTTTAAGGGGCATGTCGCCAGCCTGGCGCCGGCGACCGGCT
CACGCTTCAGCATTCTGCCGGCGGAGAACGCGACCGGGAATTTCACTAAAATCGTGCAGCGGGTGCCGGTCCGCATTGCG
CTGGAAGGTGACGGGGCAAAGCTTGACGTCCTGCGCCCGGGACTGTCGGTGATCGTCACCGTGAACGAAAAGAGCCCTCG
ATGA

Upstream 100 bases:

>100_bases
GCCTCGCCGCTGATGAAATATCGTCATGAATATCTGCTGCGCAAACGCGAAGGCGATAGCGGGCAAAAATTCCAGCCTGA
ACCTTACAGAGATGCCAGCA

Downstream 100 bases:

>100_bases
GCACCGTTCAGGCGCTGTCCGCCCCGCAGGGTCTGTCGATGCCGACGGCGAAGAAGATCTTCGCCTTCGCCAGCATGTGC
GTGGGGATGTTTATTGCCCT

Product: multidrug resistance secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNPASKKNILVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLIRID
DRDYRAALAKAAGEVAAQQAALADIQATRQLQQATITGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASAD
YRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEIARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGTQL
LSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPVRIA
LEGDGAKLDVLRPGLSVIVTVNEKSPR

Sequences:

>Translated_347_residues
MNPASKKNILVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLIRID
DRDYRAALAKAAGEVAAQQAALADIQATRQLQQATITGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASAD
YRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEIARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGTQL
LSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPVRIA
LEGDGAKLDVLRPGLSVIVTVNEKSPR
>Mature_347_residues
MNPASKKNILVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLIRID
DRDYRAALAKAAGEVAAQQAALADIQATRQLQQATITGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASAD
YRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEIARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGTQL
LSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPVRIA
LEGDGAKLDVLRPGLSVIVTVNEKSPR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=337, Percent_Identity=35.6083086053413, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788711, Length=324, Percent_Identity=35.4938271604938, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790519, Length=306, Percent_Identity=31.6993464052288, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081951, Length=303, Percent_Identity=28.0528052805281, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789637, Length=347, Percent_Identity=27.6657060518732, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790024, Length=247, Percent_Identity=23.8866396761134, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790012, Length=249, Percent_Identity=25.7028112449799, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787013, Length=331, Percent_Identity=26.8882175226586, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36874; Mature: 36874

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPASKKNILVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQ
CCCCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCEEEECCCCEECCCHHHHHHHHHHHHH
QLAVQDNMAVKKGDLLIRIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATITGSA
HHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASADYRRAHAEQEKAKADKTVAER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QLAVLDARQQQILAALAQAQANLEIARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGTQL
HHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCCCHHHHCCCCCCCCCCHHHCCHHH
LSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILP
HHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEEHHCCCCCCCCHHEECCCCCCEEEEEE
AENATGNFTKIVQRVPVRIALEGDGAKLDVLRPGLSVIVTVNEKSPR
CCCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCEEEEEEECCCCCC
>Mature Secondary Structure
MNPASKKNILVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQ
CCCCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCEEEECCCCEECCCHHHHHHHHHHHHH
QLAVQDNMAVKKGDLLIRIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATITGSA
HHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASADYRRAHAEQEKAKADKTVAER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QLAVLDARQQQILAALAQAQANLEIARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGTQL
HHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCCCHHHHCCCCCCCCCCHHHCCHHH
LSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILP
HHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEEHHCCCCCCCCHHEECCCCCCEEEEEE
AENATGNFTKIVQRVPVRIALEGDGAKLDVLRPGLSVIVTVNEKSPR
CCCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]