Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 152970069

GI number: 152970069

Start: 1686485

End: 1687885

Strand: Direct

Name: fumC [H]

Synonym: KPN_01517

Alternate gene names: 152970069

Gene position: 1686485-1687885 (Clockwise)

Preceding gene: 152970068

Following gene: 152970074

Centisome position: 31.73

GC content: 61.1

Gene sequence:

>1401_bases
ATGACAACGCATCGCAGTGAAAAAGACTCGATGGGCGCCATCGAGGTCCCGGCCGATAAACTCTGGGGCGCCCAGACCCA
GCGCTCGCTGGAGCATTTCCGCATCTCGACCGAAAAAATGCCCGGGGAGCTGATATACGCCCTGGCGCTGACCAAGCGGG
CGGCGGCGAAGGTTAACCAGGATCTCGGACTGTTGACGGCGGAGAAAGCCGGGGCGATCGTCGCCGCCGCTGACGAAGTG
CTGGCCGGAAAGCACGCGCAGGAGTTCCCCCTGGCTATCTGGCAGACCGGCTCCGGCACCCAAAGCAATATGAATATGAA
CGAGGTGCTGGCCAACCGCGCCAGTGAACTGCTCGGCGGAGAACGGGGGATGGCGCGAAAAATTCATCCCAATGACGATG
TGAATAAGAGCCAGAGCTCAAATGATGTATTCCCCACCGCCATGCACGTCGCGGCGCTGATTGCCCTGCGGGAAAAAGTG
ATCCCGTCGCTGCAGGCGCTGCGGGCGACGCTCAATGAAAAAGCGGTGGCCTTCAGGGATATCGTCAAGATCGGCCGCAC
CCATCTGCAGGACGCCACGCCGCTCACCTTAGGCCAGGAGATCTCCGGCTGGGTGGCGATGCTGGACCATAGCCTGAAGC
ACATTGAAGCCAGTCAGCCGCATCTTGCCGAGCTGGCGCTGGGCGGGACGGCGGTAGGAACCGGGCTGAATACCCATCCG
GAATATGCCGTACGGGTGGCGGCCGAGCTGGCGTCGCTCAGCGGACAGCCATTTGTCACCGCGCCGAACAAATTCGAAGC
GCTGGCCACTGTGGATGCCCTGGTCCATGCCCACGGCGCGCTGAAAGGCCTGGCGGCCTCGCTGATGAAAATCGCTAACG
ATGTCCGCTGGCTGGCCTCCGGCCCCCGCTGCGGCATTGGTGAAATCGCCATCCCGGAAAACGAGCCAGGGTCATCGATT
ATGCCGGGCAAGGTTAACCCAACCCAGTGCGAAGCTCTGACCATGGTCTGCTGCCAGGTGATGGGCAACGACGTGGCGGT
GAATATCGGCGGTGCTTCCGGCAACTTTGAGCTTAACGTCTATCGCCCGATGGTCATCCACAACTTCCTGCAGTCGGTGC
GTCTGCTGGCGGACGGTATGGCGAGCTTTAACGAGCACTGTGCGGTGGGTATTGAACCGAATCGCGAGCGGATCAGTCAG
TTGCTCAATGAGTCGCTGATGCTGGTTACTGCGCTGAATACCCATATCGGCTACGACAAGGCGGCGGAAATCGCTAAAAA
AGCGCACCATGAGGGGCTGACTCTCAAAGCCTCGGCGCTGGCGCTGGGCTACCTGACGGAAGCCGAATTCGACAGCTGGG
TGCGCCCGGAAGAGATGGTCGGCAGCCTGGCTATTCGCTAG

Upstream 100 bases:

>100_bases
GCACGAACCACCAAAACAACTTATCAATCTGGCCAATACTTAGTCTTTTAAGCAGGTGAGCTTTGTCGCTATGACGCACT
TTTCATCCAAGGAGAAAGTA

Downstream 100 bases:

>100_bases
CCAGCCAGAGGTGCAGGCGCGGGATAAGCAATCTCAGCGACTGCGCCTCCGGTTTGTAGCGATACTGCACATTGTCGGCA
TCATAGTTCAGCAGCTCGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTTHRSEKDSMGAIEVPADKLWGAQTQRSLEHFRISTEKMPGELIYALALTKRAAAKVNQDLGLLTAEKAGAIVAAADEV
LAGKHAQEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGERGMARKIHPNDDVNKSQSSNDVFPTAMHVAALIALREKV
IPSLQALRATLNEKAVAFRDIVKIGRTHLQDATPLTLGQEISGWVAMLDHSLKHIEASQPHLAELALGGTAVGTGLNTHP
EYAVRVAAELASLSGQPFVTAPNKFEALATVDALVHAHGALKGLAASLMKIANDVRWLASGPRCGIGEIAIPENEPGSSI
MPGKVNPTQCEALTMVCCQVMGNDVAVNIGGASGNFELNVYRPMVIHNFLQSVRLLADGMASFNEHCAVGIEPNRERISQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHHEGLTLKASALALGYLTEAEFDSWVRPEEMVGSLAIR

Sequences:

>Translated_466_residues
MTTHRSEKDSMGAIEVPADKLWGAQTQRSLEHFRISTEKMPGELIYALALTKRAAAKVNQDLGLLTAEKAGAIVAAADEV
LAGKHAQEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGERGMARKIHPNDDVNKSQSSNDVFPTAMHVAALIALREKV
IPSLQALRATLNEKAVAFRDIVKIGRTHLQDATPLTLGQEISGWVAMLDHSLKHIEASQPHLAELALGGTAVGTGLNTHP
EYAVRVAAELASLSGQPFVTAPNKFEALATVDALVHAHGALKGLAASLMKIANDVRWLASGPRCGIGEIAIPENEPGSSI
MPGKVNPTQCEALTMVCCQVMGNDVAVNIGGASGNFELNVYRPMVIHNFLQSVRLLADGMASFNEHCAVGIEPNRERISQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHHEGLTLKASALALGYLTEAEFDSWVRPEEMVGSLAIR
>Mature_465_residues
TTHRSEKDSMGAIEVPADKLWGAQTQRSLEHFRISTEKMPGELIYALALTKRAAAKVNQDLGLLTAEKAGAIVAAADEVL
AGKHAQEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGERGMARKIHPNDDVNKSQSSNDVFPTAMHVAALIALREKVI
PSLQALRATLNEKAVAFRDIVKIGRTHLQDATPLTLGQEISGWVAMLDHSLKHIEASQPHLAELALGGTAVGTGLNTHPE
YAVRVAAELASLSGQPFVTAPNKFEALATVDALVHAHGALKGLAASLMKIANDVRWLASGPRCGIGEIAIPENEPGSSIM
PGKVNPTQCEALTMVCCQVMGNDVAVNIGGASGNFELNVYRPMVIHNFLQSVRLLADGMASFNEHCAVGIEPNRERISQL
LNESLMLVTALNTHIGYDKAAEIAKKAHHEGLTLKASALALGYLTEAEFDSWVRPEEMVGSLAIR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=61.3882863340564, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=53.030303030303, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=87.6889848812095, Blast_Score=824, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=451, Percent_Identity=41.9068736141907, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=59.3952483801296, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.5384615384615, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=56.7099567099567, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=58.9130434782609, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=58.9130434782609, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=58.7852494577007, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=57.4837310195228, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=50.5422993492408, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49849; Mature: 49718

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHRSEKDSMGAIEVPADKLWGAQTQRSLEHFRISTEKMPGELIYALALTKRAAAKVNQ
CCCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCC
DLGLLTAEKAGAIVAAADEVLAGKHAQEFPLAIWQTGSGTQSNMNMNEVLANRASELLGG
CCCCEEHHCCCEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ERGMARKIHPNDDVNKSQSSNDVFPTAMHVAALIALREKVIPSLQALRATLNEKAVAFRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWVAMLDHSLKHIEASQPHLAELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHCCCCCCCCH
EYAVRVAAELASLSGQPFVTAPNKFEALATVDALVHAHGALKGLAASLMKIANDVRWLAS
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPRCGIGEIAIPENEPGSSIMPGKVNPTQCEALTMVCCQVMGNDVAVNIGGASGNFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
YRPMVIHNFLQSVRLLADGMASFNEHCAVGIEPNRERISQLLNESLMLVTALNTHIGYDK
ECHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCEEEEEEHHHHCCCHH
AAEIAKKAHHEGLTLKASALALGYLTEAEFDSWVRPEEMVGSLAIR
HHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TTHRSEKDSMGAIEVPADKLWGAQTQRSLEHFRISTEKMPGELIYALALTKRAAAKVNQ
CCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCC
DLGLLTAEKAGAIVAAADEVLAGKHAQEFPLAIWQTGSGTQSNMNMNEVLANRASELLGG
CCCCEEHHCCCEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ERGMARKIHPNDDVNKSQSSNDVFPTAMHVAALIALREKVIPSLQALRATLNEKAVAFRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWVAMLDHSLKHIEASQPHLAELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHCCCCCCCCH
EYAVRVAAELASLSGQPFVTAPNKFEALATVDALVHAHGALKGLAASLMKIANDVRWLAS
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPRCGIGEIAIPENEPGSSIMPGKVNPTQCEALTMVCCQVMGNDVAVNIGGASGNFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
YRPMVIHNFLQSVRLLADGMASFNEHCAVGIEPNRERISQLLNESLMLVTALNTHIGYDK
ECHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCEEEEEEHHHHCCCHH
AAEIAKKAHHEGLTLKASALALGYLTEAEFDSWVRPEEMVGSLAIR
HHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]