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The map label for this gene is 152970009

Identifier: 152970009

GI number: 152970009

Start: 1616495

End: 1617385

Strand: Direct

Name: 152970009

Synonym: KPN_01456

Alternate gene names: NA

Gene position: 1616495-1617385 (Clockwise)

Preceding gene: 152970008

Following gene: 152970014

Centisome position: 30.41

GC content: 67.56

Gene sequence:

>891_bases
ATGACAGCATTTCCTAAGGTTGCGCTAATTGGTCCCGGCGCCATCGGCACCACGATTGCCGCCGCCCTGTTTGAGAGGGG
GAGGGCGCCGATGGTCTGCGGGCGTACCGCCCATTCGGCGCTGGTGCTGCGCACTGACGAGGGTGAGATCGTGGTGCCCG
GCCCGGTGCACACCGACCCGATGGCGATAGCCGCCCCCTTCGACCTGGTCTTTGTCGCGGTGAAAACCACCCAGACGGAG
GCCATCGCCCCCTGGCTGACGGCCCTGTGTTCCCCTGACACCGTGGTGTGCGTGCTGCAAAACGGCGTTGAGCAGCGCCA
GCAGTTTGCCCCCTTGACCGGCGGCGCGACGGTGCTGCCGTCGGTGGTCTGGTTCCCGGCGCAGCGCGATGCCGATGCCT
CTGTCTGGTTGCGCGCCACGCCGCGCCTGACGCTGCCGGATCTGCCGGGGGCAGAGCGGGTGCAGCAGGCGCTGGCGGGA
ACCCGCTGCGCGGTGGACCTGGCGGCTGATTTTACCACCGTTGCCTGGCGCAAACTGTTGCAGAACGCGGTTGCCGGTCT
GATGGTGCTGACCGGACGACGCGCCGGGATGTTCGCCCGGGAGGACATCACTGCCCTCGGACTGGCTTATCTGCGCGAAT
GCCTACAGGTGGCGCGGGCGGAAGGGGCCGCCCTGAGCGACAACGTGCCGGAGGAGATTATCGCCGGCTTTCATCGGGCG
CCTGCCGACTTAAGCACCTCTATTCTGATCGATCGCCTCAATGGCCGACCGCTGGAGTGGGATATTCGTAACGGCGTGGT
GCAGCGTCGCGGGCGTCAGCACGGCATTCCGACGCCGCTCAGCGATATCATCGTGCCGCTGCTGGCGGCGGCCAGCGACG
GCCCGGGCTGA

Upstream 100 bases:

>100_bases
CTTTTCCCGACGCGCCGCTTGCCGACCTCCGGTCTTTCTCGCTACTGTGGAGGGCAATCTTTGCCTAATCTGGGCGGTGA
ATCATCAGGAGGTCTTCGGC

Downstream 100 bases:

>100_bases
CCCGGGCTGGCGCGGGGTTAGTCCACCAGGGAGGGATCGAGGTCGATCATCAACTGCTTCATCTCGGCAAAGTGCTGCCT
GGAGAAATCGGCAATCTTCT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTAFPKVALIGPGAIGTTIAAALFERGRAPMVCGRTAHSALVLRTDEGEIVVPGPVHTDPMAIAAPFDLVFVAVKTTQTE
AIAPWLTALCSPDTVVCVLQNGVEQRQQFAPLTGGATVLPSVVWFPAQRDADASVWLRATPRLTLPDLPGAERVQQALAG
TRCAVDLAADFTTVAWRKLLQNAVAGLMVLTGRRAGMFAREDITALGLAYLRECLQVARAEGAALSDNVPEEIIAGFHRA
PADLSTSILIDRLNGRPLEWDIRNGVVQRRGRQHGIPTPLSDIIVPLLAAASDGPG

Sequences:

>Translated_296_residues
MTAFPKVALIGPGAIGTTIAAALFERGRAPMVCGRTAHSALVLRTDEGEIVVPGPVHTDPMAIAAPFDLVFVAVKTTQTE
AIAPWLTALCSPDTVVCVLQNGVEQRQQFAPLTGGATVLPSVVWFPAQRDADASVWLRATPRLTLPDLPGAERVQQALAG
TRCAVDLAADFTTVAWRKLLQNAVAGLMVLTGRRAGMFAREDITALGLAYLRECLQVARAEGAALSDNVPEEIIAGFHRA
PADLSTSILIDRLNGRPLEWDIRNGVVQRRGRQHGIPTPLSDIIVPLLAAASDGPG
>Mature_295_residues
TAFPKVALIGPGAIGTTIAAALFERGRAPMVCGRTAHSALVLRTDEGEIVVPGPVHTDPMAIAAPFDLVFVAVKTTQTEA
IAPWLTALCSPDTVVCVLQNGVEQRQQFAPLTGGATVLPSVVWFPAQRDADASVWLRATPRLTLPDLPGAERVQQALAGT
RCAVDLAADFTTVAWRKLLQNAVAGLMVLTGRRAGMFAREDITALGLAYLRECLQVARAEGAALSDNVPEEIIAGFHRAP
ADLSTSILIDRLNGRPLEWDIRNGVVQRRGRQHGIPTPLSDIIVPLLAAASDGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 31341; Mature: 31209

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFPKVALIGPGAIGTTIAAALFERGRAPMVCGRTAHSALVLRTDEGEIVVPGPVHTDP
CCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCEEECCCCCCCC
MAIAAPFDLVFVAVKTTQTEAIAPWLTALCSPDTVVCVLQNGVEQRQQFAPLTGGATVLP
EEEECCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEHHCHHHHHHHCCCCCCHHHHH
SVVWFPAQRDADASVWLRATPRLTLPDLPGAERVQQALAGTRCAVDLAADFTTVAWRKLL
HHHEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHH
QNAVAGLMVLTGRRAGMFAREDITALGLAYLRECLQVARAEGAALSDNVPEEIIAGFHRA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
PADLSTSILIDRLNGRPLEWDIRNGVVQRRGRQHGIPTPLSDIIVPLLAAASDGPG
CCCCCHHHEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TAFPKVALIGPGAIGTTIAAALFERGRAPMVCGRTAHSALVLRTDEGEIVVPGPVHTDP
CCCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCEEECCCCCCCC
MAIAAPFDLVFVAVKTTQTEAIAPWLTALCSPDTVVCVLQNGVEQRQQFAPLTGGATVLP
EEEECCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEHHCHHHHHHHCCCCCCHHHHH
SVVWFPAQRDADASVWLRATPRLTLPDLPGAERVQQALAGTRCAVDLAADFTTVAWRKLL
HHHEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHH
QNAVAGLMVLTGRRAGMFAREDITALGLAYLRECLQVARAEGAALSDNVPEEIIAGFHRA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
PADLSTSILIDRLNGRPLEWDIRNGVVQRRGRQHGIPTPLSDIIVPLLAAASDGPG
CCCCCHHHEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]