| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is ytbE [H]
Identifier: 152969868
GI number: 152969868
Start: 1476760
End: 1477596
Strand: Direct
Name: ytbE [H]
Synonym: KPN_01315
Alternate gene names: 152969868
Gene position: 1476760-1477596 (Clockwise)
Preceding gene: 152969867
Following gene: 152969869
Centisome position: 27.78
GC content: 53.64
Gene sequence:
>837_bases ATGCCGATGCTGGGTTTCGGCGTTTTCAAGGTGACCGATAAAGCGGAGTGTAAGCAGGCGGTGTTGAACGCCATTCGCAC CGGTTATCGCCTCATCGATACCGCTGCCGTCTACGATAATGAAGATGCGGTGGGTGAGGCCGTGCGCGAAGCCATCGCCG AAGGTCTGTGTACCCGCGAGGCGCTGTTTATTACCTCCAAACTGTGGGTCCAGGACATGGCCAACACCGGGATGGCGAAA GCCGGGATTGCCGCGTCATTAAAAAAATCGGGCCTGGAATACTTTGATCTTTATTTGCTACATCAGGCGATGGGCGATTA TTTCAGCGCCTGGCGTGCGCTGGAAGAGGCCTATGAGGCCGGTACCCTGAAAGCGATCGGCGTCTCCAATTTTTACCCCC ATGTGTTAGCTAACTTCTGCGAAACTGTCAGAATTAAACCAATGGTGAACCAGGTTGAACTGCATCCTTATTTCGCGCAG CCCGCGGCGCTGGAAGCCATGAAGCATTATCACGTTCAGCCTGAAGCGTGGGCGCCGTTAGGCGGTGGCAGACATAATCC GTATCAAGATGCATTGCTTCGGGGGATCGCCGATGCGCACCAGAAAACCATTGCGCAGGTTGTTCTGCGCTGGAACGTGC AGCGTGGCGTCACGGTGATCCCTAAATCCACCCGCCAGGAGCGCATTGAAGAAAATTTTGCTATCTGGGATTTCGTATTA ACAGATAACGAAATGGCGCAAATCAGCGCCCTGGATTTAGGCTATGTTGGCGAAGCGGTAAAACACTTCAACCCTGAGTT CGTTCGCGGATGTCTGGGGGTGAAAATCCACGACTGA
Upstream 100 bases:
>100_bases AATGACAGGCTAATCGTGACCGCGTTCCTGTCTTACCATGGTGTTTTAACAAGAGGGGAGCTTCACCGTGGAATATTCAA TATTAAGTAACGCTCGCAAA
Downstream 100 bases:
>100_bases TTGCGGCATCGGCTGATTCGATATCCATCTCCTCGCCTGCGCTGCGGCGACGGGTTCAGTATGCTGGTTAGCGCCCACGC GTTTGCCGCGATGGTTGTCA
Product: aldo/keto reductase family protein
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 278; Mature: 277
Protein sequence:
>278_residues MPMLGFGVFKVTDKAECKQAVLNAIRTGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLWVQDMANTGMAK AGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQ PAALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERIEENFAIWDFVL TDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Sequences:
>Translated_278_residues MPMLGFGVFKVTDKAECKQAVLNAIRTGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLWVQDMANTGMAK AGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQ PAALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERIEENFAIWDFVL TDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD >Mature_277_residues PMLGFGVFKVTDKAECKQAVLNAIRTGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLWVQDMANTGMAKA GIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQP AALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERIEENFAIWDFVLT DNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI5174695, Length=288, Percent_Identity=39.9305555555556, Blast_Score=189, Evalue=2e-48, Organism=Homo sapiens, GI300116273, Length=271, Percent_Identity=38.7453874538745, Blast_Score=171, Evalue=7e-43, Organism=Homo sapiens, GI310109922, Length=265, Percent_Identity=36.9811320754717, Blast_Score=169, Evalue=3e-42, Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=36.013986013986, Blast_Score=167, Evalue=7e-42, Organism=Homo sapiens, GI45446745, Length=286, Percent_Identity=35.3146853146853, Blast_Score=167, Evalue=8e-42, Organism=Homo sapiens, GI4503285, Length=286, Percent_Identity=35.3146853146853, Blast_Score=167, Evalue=8e-42, Organism=Homo sapiens, GI310109920, Length=286, Percent_Identity=34.965034965035, Blast_Score=167, Evalue=8e-42, Organism=Homo sapiens, GI5453543, Length=286, Percent_Identity=34.965034965035, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI300116271, Length=265, Percent_Identity=38.8679245283019, Blast_Score=165, Evalue=3e-41, Organism=Homo sapiens, GI24497583, Length=286, Percent_Identity=34.6153846153846, Blast_Score=164, Evalue=6e-41, Organism=Homo sapiens, GI24497585, Length=289, Percent_Identity=34.6020761245675, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=34.6153846153846, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=34.6153846153846, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=34.8754448398576, Blast_Score=155, Evalue=3e-38, Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=31.7567567567568, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI4502049, Length=280, Percent_Identity=34.6428571428571, Blast_Score=147, Evalue=2e-35, Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=36, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI207028673, Length=103, Percent_Identity=42.7184466019417, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI310109926, Length=103, Percent_Identity=41.747572815534, Blast_Score=82, Evalue=5e-16, Organism=Escherichia coli, GI87082198, Length=257, Percent_Identity=40.0778210116732, Blast_Score=196, Evalue=2e-51, Organism=Escherichia coli, GI1786400, Length=257, Percent_Identity=32.6848249027237, Blast_Score=129, Evalue=3e-31, Organism=Caenorhabditis elegans, GI17550248, Length=277, Percent_Identity=38.2671480144404, Blast_Score=174, Evalue=6e-44, Organism=Caenorhabditis elegans, GI17537077, Length=282, Percent_Identity=35.8156028368794, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=34.6666666666667, Blast_Score=161, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17537075, Length=285, Percent_Identity=35.0877192982456, Blast_Score=157, Evalue=4e-39, Organism=Caenorhabditis elegans, GI17566692, Length=280, Percent_Identity=34.6428571428571, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17561298, Length=268, Percent_Identity=30.9701492537313, Blast_Score=137, Evalue=7e-33, Organism=Caenorhabditis elegans, GI71998625, Length=261, Percent_Identity=32.5670498084291, Blast_Score=136, Evalue=1e-32, Organism=Caenorhabditis elegans, GI17538386, Length=266, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17552492, Length=270, Percent_Identity=28.5185185185185, Blast_Score=123, Evalue=8e-29, Organism=Caenorhabditis elegans, GI17562292, Length=269, Percent_Identity=26.3940520446097, Blast_Score=116, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17537079, Length=290, Percent_Identity=26.8965517241379, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17561300, Length=266, Percent_Identity=28.9473684210526, Blast_Score=107, Evalue=6e-24, Organism=Saccharomyces cerevisiae, GI6321896, Length=297, Percent_Identity=33.6700336700337, Blast_Score=169, Evalue=4e-43, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=30.4964539007092, Blast_Score=140, Evalue=3e-34, Organism=Saccharomyces cerevisiae, GI6324694, Length=275, Percent_Identity=31.2727272727273, Blast_Score=137, Evalue=3e-33, Organism=Saccharomyces cerevisiae, GI6319625, Length=310, Percent_Identity=31.2903225806452, Blast_Score=130, Evalue=2e-31, Organism=Saccharomyces cerevisiae, GI6322556, Length=261, Percent_Identity=32.5670498084291, Blast_Score=129, Evalue=3e-31, Organism=Saccharomyces cerevisiae, GI6320079, Length=237, Percent_Identity=31.2236286919831, Blast_Score=111, Evalue=1e-25, Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=38.4083044982699, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI21356425, Length=281, Percent_Identity=36.2989323843416, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI24662789, Length=285, Percent_Identity=34.7368421052632, Blast_Score=168, Evalue=3e-42, Organism=Drosophila melanogaster, GI24663317, Length=293, Percent_Identity=37.2013651877133, Blast_Score=166, Evalue=2e-41, Organism=Drosophila melanogaster, GI20129731, Length=300, Percent_Identity=35, Blast_Score=162, Evalue=2e-40, Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=32.6241134751773, Blast_Score=157, Evalue=7e-39, Organism=Drosophila melanogaster, GI24662785, Length=271, Percent_Identity=37.2693726937269, Blast_Score=150, Evalue=8e-37, Organism=Drosophila melanogaster, GI24644950, Length=290, Percent_Identity=33.448275862069, Blast_Score=149, Evalue=2e-36, Organism=Drosophila melanogaster, GI24662781, Length=271, Percent_Identity=36.90036900369, Blast_Score=147, Evalue=6e-36, Organism=Drosophila melanogaster, GI221378297, Length=310, Percent_Identity=31.2903225806452, Blast_Score=141, Evalue=4e-34, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=32.156862745098, Blast_Score=137, Evalue=6e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 30977; Mature: 30846
Theoretical pI: Translated: 6.24; Mature: 6.24
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPMLGFGVFKVTDKAECKQAVLNAIRTGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTRE CCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH ALFITSKLWVQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEA HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC GTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQPAALEAMKHYHVQPEAWAPL CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCCCCCC GGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERIEENFAIWDFVL CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCEEEEEEE TDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECC >Mature Secondary Structure PMLGFGVFKVTDKAECKQAVLNAIRTGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTRE CCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH ALFITSKLWVQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEA HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC GTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQPAALEAMKHYHVQPEAWAPL CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCCCCCC GGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERIEENFAIWDFVL CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCEEEEEEE TDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]