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The map label for this gene is proY [H]

Identifier: 152968916

GI number: 152968916

Start: 383940

End: 385259

Strand: Direct

Name: proY [H]

Synonym: KPN_00343

Alternate gene names: 152968916

Gene position: 383940-385259 (Clockwise)

Preceding gene: 152968915

Following gene: 152968917

Centisome position: 7.22

GC content: 59.02

Gene sequence:

>1320_bases
ATGGCTCTGGGTTCCGCCATCGGCACCGGGCTTTTTTACGGCTCGGCCGACGCCATTAAAATGGCCGGACCCAGCGTACT
GTTGGCCTACATTATCGGCGGCGTCGCGGCATATATCATTATGCGGGCGCTCGGTGAGATGTCGGTGCATAACCCTGCCG
CCAGCTCATTCTCCCGCTATGCCCAGGAAAACCTCGGCGGACTGGCGGGCTATATCACCGGCTGGACCTACTGCTTTGAA
ATCCTGATCGTCGCCATCGCCGACGTTACCGCCTTCGGCATCTACATGGGCGTCTGGTTCCCGACGGTGCCGCACTGGAT
CTGGGTGCTCAGCGTGGTGCTGATCATCTGCGCCGTCAACCTGATGAGCGTCAAGGTGTTTGGCGAGCTGGAGTTCTGGT
TCTCGTTCTTCAAAGTGGCCACCATTATCATCATGATCCTCGCCGGGTTCGGCATCATTATCTGGGGGATCGGCAACGGC
GGCCAGCCGACGGGGATTCATAACCTGTGGAGCAACGGCGGCTTCTTCAGCAACGGCTGGCTGGGAATGGTGATGTCGCT
GCAGATGGTGATGTTCGCTTACGGCGGCATCGAAATCATCGGCATTACCGCCGGTGAGGCGAAGGACCCGGAGAAATCCA
TTCCGCGCGCCATCAACTCGGTGCCGATGCGCATTCTGGTGTTCTATGTCGGCACGCTGTTCGTCATTATGTCCATCTAC
CCGTGGAATCAGGTGGGAACCGACGGCAGCCCCTTCGTCCTGACCTTCCAGCATCTGGGCATTACCTTCGCGGCCAGTAT
TCTTAACTTCGTGGTCCTGACGGCTTCGCTGTCGGCGATTAACTCCGACGTGTTCGGCGTGGGCCGTATGCTGCACGGCA
TGGCTGAGCAGGGCAGCGCGCCGAAGGTGTTCGCTAAAACGTCGCGTCGCGGTATTCCGTGGGTGACGGTGATGGTGATG
ACCATTGCGCTCCTGTTTGCGGTATACCTAAATTACATCATGCCGGAGAACGTTTTCCTGGTGATCGCCTCCCTGGCCAC
CTTCGCCACGGTGTGGGTGTGGATTATGATCCTGCTGTCACAGATAGCCTTCCGCCGCCGTCTGTCGCCCGAAGAGGTTA
AGGCGCTGAAATTCAAAGTCCCTGGCGGGGTGGTGACCACGGTGATCGGCCTGCTGTTCCTGGCCTTTATTATCGCCCTT
ATCGGCTATCATCCGGACACCCGCATCTCGCTGTACGTCGGTATGGCGTGGATTGCGCTGTTGCTGCTCGGCTGGGTCTT
TAAGACCCGCCGTGAGCGCCGCCTGGCGCAGGCTCAGTAA

Upstream 100 bases:

>100_bases
TCCGTGGTTTTTTATTTTTTGTGTTAAACGGCATTGAAAAACCACGATGGAAAGTAGTAACAAGCTTAAGCGCGGGCTAA
GCACCCGGCACATTCGCTTT

Downstream 100 bases:

>100_bases
TCGACATCGCCCCGGTCAGCATCGCGCGACCGGGGCGGCTTGCGGTCCCGCGTCCTCCCCCGTTATCCTCCCCCAAAAAG
TTCTGAGATGATGAGTTCTG

Product: putative proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQENLGGLAGYITGWTYCFE
ILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNG
GQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIY
PWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVMVM
TIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIAL
IGYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLAQAQ

Sequences:

>Translated_439_residues
MALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQENLGGLAGYITGWTYCFE
ILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNG
GQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIY
PWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVMVM
TIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIAL
IGYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLAQAQ
>Mature_438_residues
ALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQENLGGLAGYITGWTYCFEI
LIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNGG
QPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYP
WNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVMVMT
IALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIALI
GYHPDTRISLYVGMAWIALLLLGWVFKTRRERRLAQAQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=325, Percent_Identity=24.9230769230769, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI110347453, Length=336, Percent_Identity=25.297619047619, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786602, Length=439, Percent_Identity=93.8496583143508, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=437, Percent_Identity=45.5377574370709, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1786302, Length=433, Percent_Identity=43.8799076212471, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI48994972, Length=441, Percent_Identity=43.5374149659864, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1790653, Length=438, Percent_Identity=40.8675799086758, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87081915, Length=389, Percent_Identity=39.3316195372751, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87081708, Length=442, Percent_Identity=36.4253393665158, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788480, Length=394, Percent_Identity=37.0558375634518, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789017, Length=414, Percent_Identity=34.0579710144928, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081869, Length=176, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082023, Length=280, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=411, Percent_Identity=22.6277372262774, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=357, Percent_Identity=24.0896358543417, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=450, Percent_Identity=32.8888888888889, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=387, Percent_Identity=33.5917312661499, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=427, Percent_Identity=32.3185011709602, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=372, Percent_Identity=31.4516129032258, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=28.6783042394015, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6324924, Length=431, Percent_Identity=30.1624129930394, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322892, Length=402, Percent_Identity=30.8457711442786, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=441, Percent_Identity=26.984126984127, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=383, Percent_Identity=32.1148825065274, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=387, Percent_Identity=27.390180878553, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=413, Percent_Identity=26.634382566586, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=387, Percent_Identity=26.8733850129199, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=382, Percent_Identity=27.4869109947644, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6321053, Length=409, Percent_Identity=25.6723716381418, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=24.9433106575964, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322967, Length=382, Percent_Identity=25.3926701570681, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=416, Percent_Identity=25, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=493, Percent_Identity=24.1379310344828, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47951; Mature: 47820

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRY
CCCCHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AQENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVN
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCCCH
LGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIY
HHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PKVFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLS
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
QIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIALIGYHPDTRISLYVGMAWIAL
HHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLLGWVFKTRRERRLAQAQ
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRY
CCCHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AQENLGGLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVN
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSVKVFGELEFWFSFFKVATIIIMILAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCCCH
LGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIY
HHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNQVGTDGSPFVLTFQHLGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PKVFAKTSRRGIPWVTVMVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLS
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
QIAFRRRLSPEEVKALKFKVPGGVVTTVIGLLFLAFIIALIGYHPDTRISLYVGMAWIAL
HHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLLGWVFKTRRERRLAQAQ
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]