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The map label for this gene is ubiB [H]

Identifier: 150398754

GI number: 150398754

Start: 3777541

End: 3779115

Strand: Reverse

Name: ubiB [H]

Synonym: Smed_3571

Alternate gene names: 150398754

Gene position: 3779115-3777541 (Counterclockwise)

Preceding gene: 150398755

Following gene: 150398753

Centisome position: 99.93

GC content: 64.7

Gene sequence:

>1575_bases
ATGAGCACGCCAGGCGCATATTTCCGTCTCATACGGATCGGCTGGGTCCTTGCGCGCGAGAACGCGTTTGCGGCGGTCCC
CTCCGAACACCTGCCCCCGCTCGCACGTTTCGTGCAGAAGCTCGCCGGCCTATTGGCCCGCCGCGAGGCGCGCCTCGAGG
AGCGCAACGACCGGCTTGCCCGCGCGGTGGAACGGCTCGGCCCCTCCTATGTCAAGATCGGCCAGTTCCTGGCCACACGA
CCGGATGTGGTCGGCGCCGAGCTTGCCGCCGACCTGTCGCTGCTGCAGGACCGCATGGCGACCTTTCCGCAGAGCGAATC
AAGGGCTGCGATCGAAGCGTCGCTCGGCCGGCCGGTCGATGCACTGTTCCTCGAATTTTCCGAGCCCGTTGCAGCCGCAT
CGATCGCCCAGGTTCACGCCGCCGTGATCATGCGCGACGGCAAACGCGAACGGGTTGCGGTCAAGGTCGTTCGCCCCGGC
GTGCGCCAGCGTTTCGCCGCCGACATCGAAGCCATGTACCTGGTTTCGCGCATGCAGGAGCGGTTCCTGCCCTATACGCG
TCGCCTCAGGCCCGTCGAGGTGACGAGGACGCTCGAGCAGACGACCAAGGTCGAAATGGACCTGAGGCTCGAGGCCGCCG
CGCTTTCCGAACTCGGCGAGAACACCAAGGAGGATTCCGGTTTTCGCGTGCCCAGGGTCGACTGGGAGCGCACCGGCCGG
GACGTCGTGACGATGGAATGGATCGACGGCGTCAAGATGTCGGATATCGAAGGCCTGAAAAGGGCCGGTCACGACCTGAA
CCGCCTTGCAGAAACGCTCATCCAGTCCTTTCTGCGCCACACGCTCAGGGACGGGTTCTTCCACGCGGACATGCACCAGG
GCAACCTGTTCGTCGACGATGCGGGCCATATCGTCGCCGTCGACATGGGGATTGTCGGCCGCCTCGGCCGCAAGGAACGC
CGCTTCCTCGCAGAAATCCTCTACGGCTTCATCATGCGCGATTATCAGCGTGTCGCGGACGTCCATTTCGAGGCCGGTTA
CGTTCCCTCGCATCACGACGCCGCAAGCTTCGCCCAGGCGATCCGCGCCATTGGAGAGCCGATCCACGGCCAGCCGGCCG
AAACTATCTCCATGGCGAAGCTTCTGACGCTGCTTTTCGAGGTCACCGAGCTTTTCGACATGCAGACGCGTCCCGAACTG
GTGATGCTGCAGAAGACCATGGTCGTCGTCGAGGGTGTCGCCCGAACGCTCAACCCGCGCTTCAACATGTGGAAGGCCTC
CGAGCCGGTCGTCGGCAGGTGGATACGGGACAATCTCGGACCGAAGCGCATCGTCGCGGATCTGCGCGATGGCATGCATG
CGGCGCTCCGGGTCGCCGAGGCGCTTCCGGAAATCGCGGCCAGGACGGAACGCTTCTCCGCAGACGTCATGGCGATGAGC
GAAAAGGGCTTGCGCTTCGATGCGGATACCTCGGAAGCGATCGGCAGAGCCGAAGCGCGGCACACGCGCTCCGGCCGCAT
TGCATTGTGGGTGATCGCGGCCACGCTCACCTACATCGCCTGGCAGCTTGCGTGA

Upstream 100 bases:

>100_bases
TTCGCCGCCATGATCCGCGATGCCGGCTTCGCGCGCGTCTCCTTCACCAACTATACCGGCGGCATAGCAGCGCTGCATTC
CGGCTGGAAAATCTGAACGC

Downstream 100 bases:

>100_bases
CGGTTGATAGAATGCCGCTCGCCTGAGGCTCCGAACCATCCCCCGCTGGGGTGAGAAAGCTGTCGAAGCAGGAGGAATGA
ACCATGGATCTCGGCATCGA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSTPGAYFRLIRIGWVLARENAFAAVPSEHLPPLARFVQKLAGLLARREARLEERNDRLARAVERLGPSYVKIGQFLATR
PDVVGAELAADLSLLQDRMATFPQSESRAAIEASLGRPVDALFLEFSEPVAAASIAQVHAAVIMRDGKRERVAVKVVRPG
VRQRFAADIEAMYLVSRMQERFLPYTRRLRPVEVTRTLEQTTKVEMDLRLEAAALSELGENTKEDSGFRVPRVDWERTGR
DVVTMEWIDGVKMSDIEGLKRAGHDLNRLAETLIQSFLRHTLRDGFFHADMHQGNLFVDDAGHIVAVDMGIVGRLGRKER
RFLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMQTRPEL
VMLQKTMVVVEGVARTLNPRFNMWKASEPVVGRWIRDNLGPKRIVADLRDGMHAALRVAEALPEIAARTERFSADVMAMS
EKGLRFDADTSEAIGRAEARHTRSGRIALWVIAATLTYIAWQLA

Sequences:

>Translated_524_residues
MSTPGAYFRLIRIGWVLARENAFAAVPSEHLPPLARFVQKLAGLLARREARLEERNDRLARAVERLGPSYVKIGQFLATR
PDVVGAELAADLSLLQDRMATFPQSESRAAIEASLGRPVDALFLEFSEPVAAASIAQVHAAVIMRDGKRERVAVKVVRPG
VRQRFAADIEAMYLVSRMQERFLPYTRRLRPVEVTRTLEQTTKVEMDLRLEAAALSELGENTKEDSGFRVPRVDWERTGR
DVVTMEWIDGVKMSDIEGLKRAGHDLNRLAETLIQSFLRHTLRDGFFHADMHQGNLFVDDAGHIVAVDMGIVGRLGRKER
RFLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMQTRPEL
VMLQKTMVVVEGVARTLNPRFNMWKASEPVVGRWIRDNLGPKRIVADLRDGMHAALRVAEALPEIAARTERFSADVMAMS
EKGLRFDADTSEAIGRAEARHTRSGRIALWVIAATLTYIAWQLA
>Mature_523_residues
STPGAYFRLIRIGWVLARENAFAAVPSEHLPPLARFVQKLAGLLARREARLEERNDRLARAVERLGPSYVKIGQFLATRP
DVVGAELAADLSLLQDRMATFPQSESRAAIEASLGRPVDALFLEFSEPVAAASIAQVHAAVIMRDGKRERVAVKVVRPGV
RQRFAADIEAMYLVSRMQERFLPYTRRLRPVEVTRTLEQTTKVEMDLRLEAAALSELGENTKEDSGFRVPRVDWERTGRD
VVTMEWIDGVKMSDIEGLKRAGHDLNRLAETLIQSFLRHTLRDGFFHADMHQGNLFVDDAGHIVAVDMGIVGRLGRKERR
FLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMQTRPELV
MLQKTMVVVEGVARTLNPRFNMWKASEPVVGRWIRDNLGPKRIVADLRDGMHAALRVAEALPEIAARTERFSADVMAMSE
KGLRFDADTSEAIGRAEARHTRSGRIALWVIAATLTYIAWQLA

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=31.1355311355311, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI40254938, Length=278, Percent_Identity=26.6187050359712, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI217035081, Length=287, Percent_Identity=25.0871080139373, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI27363457, Length=330, Percent_Identity=27.5757575757576, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI217416386, Length=269, Percent_Identity=30.1115241635688, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI34147522, Length=305, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI2367309, Length=468, Percent_Identity=35.6837606837607, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=26.9230769230769, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=22.6027397260274, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=291, Percent_Identity=25.4295532646048, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=322, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24662575, Length=347, Percent_Identity=28.8184438040346, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI22024280, Length=256, Percent_Identity=27.34375, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58852; Mature: 58720

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPGAYFRLIRIGWVLARENAFAAVPSEHLPPLARFVQKLAGLLARREARLEERNDRLA
CCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVERLGPSYVKIGQFLATRPDVVGAELAADLSLLQDRMATFPQSESRAAIEASLGRPVD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHH
ALFLEFSEPVAAASIAQVHAAVIMRDGKRERVAVKVVRPGVRQRFAADIEAMYLVSRMQE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RFLPYTRRLRPVEVTRTLEQTTKVEMDLRLEAAALSELGENTKEDSGFRVPRVDWERTGR
HHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
DVVTMEWIDGVKMSDIEGLKRAGHDLNRLAETLIQSFLRHTLRDGFFHADMHQGNLFVDD
CEEEEHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
AGHIVAVDMGIVGRLGRKERRFLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQA
CCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMQTRPELVMLQKTMVVVEGVARTLNPR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKASEPVVGRWIRDNLGPKRIVADLRDGMHAALRVAEALPEIAARTERFSADVMAMS
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKGLRFDADTSEAIGRAEARHTRSGRIALWVIAATLTYIAWQLA
CCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPGAYFRLIRIGWVLARENAFAAVPSEHLPPLARFVQKLAGLLARREARLEERNDRLA
CCCHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVERLGPSYVKIGQFLATRPDVVGAELAADLSLLQDRMATFPQSESRAAIEASLGRPVD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHH
ALFLEFSEPVAAASIAQVHAAVIMRDGKRERVAVKVVRPGVRQRFAADIEAMYLVSRMQE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RFLPYTRRLRPVEVTRTLEQTTKVEMDLRLEAAALSELGENTKEDSGFRVPRVDWERTGR
HHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
DVVTMEWIDGVKMSDIEGLKRAGHDLNRLAETLIQSFLRHTLRDGFFHADMHQGNLFVDD
CEEEEHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEC
AGHIVAVDMGIVGRLGRKERRFLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQA
CCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMQTRPELVMLQKTMVVVEGVARTLNPR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKASEPVVGRWIRDNLGPKRIVADLRDGMHAALRVAEALPEIAARTERFSADVMAMS
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKGLRFDADTSEAIGRAEARHTRSGRIALWVIAATLTYIAWQLA
CCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA