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The map label for this gene is ubiE [H]

Identifier: 150398755

GI number: 150398755

Start: 3779120

End: 3779896

Strand: Reverse

Name: ubiE [H]

Synonym: Smed_3572

Alternate gene names: 150398755

Gene position: 3779896-3779120 (Counterclockwise)

Preceding gene: NA

Following gene: 150398754

Centisome position: 99.95

GC content: 61.9

Gene sequence:

>777_bases
ATGGCGGACGAGCGCGTATCGGCGAGTGGCGGAATGGAGACCTCTTTCGGTTTTCGCGAAGTCGGCACGGGCGAGAAGCA
GCCGCTCGTCAACGATGTCTTCCACAAGGTCGCCAAACGCTACGACATCATGAACGACGTGATGTCGGCCGGGCTGCACC
GCGTCTGGAAGGATGCGATGATCGCGGCGCTCAACCCGCCGGGCCGCGAGGACTACCGGGTCCTCGACGTCGCCGGCGGC
ACCGGCGACATCGCCTTCCGTATTGTCGAGCGCTCCGGGCGCAAGGCTCAAGCGACCGTGCTCGACATCAACGGCTCGAT
GCTTTCGGTCGGTGCCGAGCGGGCGCGCAAGAAGGGCATCGAAGCCAATCTCGAATTCGTCGAGGCCAATGCCGAAGACC
TGCCTTTCGCGGCGAATTCCTTCGACGCCTATACGATCGCCTTCGGTATTCGCAACGTGCCGCGCATCGAAGTGGCTCTG
CGCGAGGCCTATCGGGTGCTGAAGCGCGGCGGGCGGCTGCTCGTACTCGAGTTCTCCGAGGTCGAGATGCCGCTGCTCGA
CCGCTTCTACGATGCATGGTCCTTCAATGCGATCCCGAAATTCGGCAAGCTCATCACCGGTGACGATGCACCTTACCAAT
ATCTGGTCGAATCGATCCGCAAGTTTCCAAACCAACGCGATTTCGCCGCCATGATCCGCGATGCCGGCTTCGCGCGCGTC
TCCTTCACCAACTATACCGGCGGCATAGCAGCGCTGCATTCCGGCTGGAAAATCTGA

Upstream 100 bases:

>100_bases
ATCCCGCTGCATGCGGCCGCCGGTCGCTTCTCGCCCAGATAGCGTGCGACGGGCGATTTCGCTATGGTGCCGGCAAAATT
CGTTGAAGTGGAGTATTCGT

Downstream 100 bases:

>100_bases
ACGCATGAGCACGCCAGGCGCATATTTCCGTCTCATACGGATCGGCTGGGTCCTTGCGCGCGAGAACGCGTTTGCGGCGG
TCCCCTCCGAACACCTGCCC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MADERVSASGGMETSFGFREVGTGEKQPLVNDVFHKVAKRYDIMNDVMSAGLHRVWKDAMIAALNPPGREDYRVLDVAGG
TGDIAFRIVERSGRKAQATVLDINGSMLSVGAERARKKGIEANLEFVEANAEDLPFAANSFDAYTIAFGIRNVPRIEVAL
REAYRVLKRGGRLLVLEFSEVEMPLLDRFYDAWSFNAIPKFGKLITGDDAPYQYLVESIRKFPNQRDFAAMIRDAGFARV
SFTNYTGGIAALHSGWKI

Sequences:

>Translated_258_residues
MADERVSASGGMETSFGFREVGTGEKQPLVNDVFHKVAKRYDIMNDVMSAGLHRVWKDAMIAALNPPGREDYRVLDVAGG
TGDIAFRIVERSGRKAQATVLDINGSMLSVGAERARKKGIEANLEFVEANAEDLPFAANSFDAYTIAFGIRNVPRIEVAL
REAYRVLKRGGRLLVLEFSEVEMPLLDRFYDAWSFNAIPKFGKLITGDDAPYQYLVESIRKFPNQRDFAAMIRDAGFARV
SFTNYTGGIAALHSGWKI
>Mature_257_residues
ADERVSASGGMETSFGFREVGTGEKQPLVNDVFHKVAKRYDIMNDVMSAGLHRVWKDAMIAALNPPGREDYRVLDVAGGT
GDIAFRIVERSGRKAQATVLDINGSMLSVGAERARKKGIEANLEFVEANAEDLPFAANSFDAYTIAFGIRNVPRIEVALR
EAYRVLKRGGRLLVLEFSEVEMPLLDRFYDAWSFNAIPKFGKLITGDDAPYQYLVESIRKFPNQRDFAAMIRDAGFARVS
FTNYTGGIAALHSGWKI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=280, Percent_Identity=48.5714285714286, Blast_Score=254, Evalue=8e-68,
Organism=Escherichia coli, GI48994983, Length=244, Percent_Identity=48.3606557377049, Blast_Score=235, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17557039, Length=249, Percent_Identity=51.8072289156626, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323526, Length=258, Percent_Identity=43.4108527131783, Blast_Score=202, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24641702, Length=272, Percent_Identity=46.6911764705882, Blast_Score=240, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28639; Mature: 28508

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADERVSASGGMETSFGFREVGTGEKQPLVNDVFHKVAKRYDIMNDVMSAGLHRVWKDAM
CCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAALNPPGREDYRVLDVAGGTGDIAFRIVERSGRKAQATVLDINGSMLSVGAERARKKGI
EEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCEEHHHHHHHHHCCC
EANLEFVEANAEDLPFAANSFDAYTIAFGIRNVPRIEVALREAYRVLKRGGRLLVLEFSE
CCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
VEMPLLDRFYDAWSFNAIPKFGKLITGDDAPYQYLVESIRKFPNQRDFAAMIRDAGFARV
CCHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEE
SFTNYTGGIAALHSGWKI
EECCCCCCHHHHCCCCCC
>Mature Secondary Structure 
ADERVSASGGMETSFGFREVGTGEKQPLVNDVFHKVAKRYDIMNDVMSAGLHRVWKDAM
CCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAALNPPGREDYRVLDVAGGTGDIAFRIVERSGRKAQATVLDINGSMLSVGAERARKKGI
EEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCEEHHHHHHHHHCCC
EANLEFVEANAEDLPFAANSFDAYTIAFGIRNVPRIEVALREAYRVLKRGGRLLVLEFSE
CCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
VEMPLLDRFYDAWSFNAIPKFGKLITGDDAPYQYLVESIRKFPNQRDFAAMIRDAGFARV
CCHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEE
SFTNYTGGIAALHSGWKI
EECCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]