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The map label for this gene is guaA [H]

Identifier: 150398701

GI number: 150398701

Start: 3719416

End: 3720978

Strand: Reverse

Name: guaA [H]

Synonym: Smed_3517

Alternate gene names: 150398701

Gene position: 3720978-3719416 (Counterclockwise)

Preceding gene: 150398702

Following gene: 150398699

Centisome position: 98.39

GC content: 63.85

Gene sequence:

>1563_bases
ATGACCCAGACAGCCCATCCCGATACCGTCCTCATCGTCGATTTCGGCAGCCAGGTGACCCAGCTCATCGCCAGGCGCGT
GCGCGAATCCGGCGTCTATTGCGAGATCGTGCCGTTCCAGTCGGCCGAGGACGGTTTCCATCGCCTGAAGCCGAAGGCGG
TGATCCTGTCCGGCAGCCCGGCTTCGACGCTCGACGTCGGCTCGCCGCGTGCGCCTTCCGTCATTTTCGAAAGCGGCCTG
CCGGTCTTCGGCATCTGCTACGGTCAGCAGACCATGTGCGCGCAGCTCGGCGGCAAGGTCGAAAGCGGGCATCATCGTGA
ATTCGGCCGGGCTTTCCTCGAAGTCGAAAAGGACTGCCCGCTCTTCGAGGGGCTCTGGTCCCTCGGCTCGCGGCACCAGG
TGTGGATGTCGCATGGCGACCGGGTTACCGCCTTGCCCGATGGCTTCGAAGTCGTCGCCACCTCTTCCAACGCGCCCTTC
GCCTTCATCGCAGACGAGAAGCGCAGATACTATGCCGTCCAGTTCCATCCGGAAGTGGTGCATACGCCCGACGGGGCGAA
GCTCATCGCCAACTTCGTCCACAAGATCGCCGGCATCAAGGGCGATTGGACGATGTCGGCCTATCGCGCCAAGGCGGTCG
AAGCGATCCGCAACCAGGTCGGCGACAAGAAGGTGATCTGCGCGCTTTCCGGCGGCGTCGATTCGTCGGTTGCAGCACTC
CTCATCCACGAAGCCGTCGGCGACCAGCTCACCTGCATCCTCGTCGACCACGGTCTGATGCGCAAGGACGAGGCGGCGAA
CGTCGTCGCGATGTTCAAGGAGCACTACAACCTCCATCTGCTCCACGTCGACGCTTCCGACCGCTTCATTGGCGAACTCG
AAGGCGTCAGCGATCCGGAGACCAAGCGCAAGATCATCGGCCGCCTCTTCATCGAGGTCTTCGAGGAAGAGGCCGGGAAG
CTGGGCGGGGCAGATTTCCTCGCGCAGGGCACGCTTTATCCCGACGTCATCGAAAGCGTCTCCTTCACCGGCGGCCCTTC
GGTGACGATCAAATCGCACCACAATGTCGGCGGCCTGCCGGAGCGCATGAACATGCAGCTCGTCGAACCGCTGCGCGAAC
TCTTCAAGGACGAGGTACGCGTCCTCGGCCGCGAGCTCGGCCTGCCCGACAGCTTCATCGGCCGCCATCCCTTCCCCGGT
CCCGGCCTTGCGATCCGCTGCCCCGGCGGGATCAGCCGCGAGAAGCTCGAAATTCTGCGCGAGGCGGATGCGATCTATCT
TGACGAGATCCGCAAGGCAGGCCTCTACGACGCCATCTGGCAGGCCTTCGCCGTGCTGCTTCCCGTGCAGACGGTCGGCG
TCATGGGCGACGGGCGCACTTATGAATTCGTCTGCGCGCTTCGCGCCGTCACCTCCGTCGACGGCATGACGGCCGATTTC
TACCACTATGACATGGAATTCCTGGGCCGCGCTGCCACGCGCATCATCAACGAGGTCCGCGGCATCAACCGCGTCGTCTA
CGACGTCACCTCGAAGCCCCCGGGCACGATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
TTTAGAGGACGCTTGATTGTCCGGGTGCAATGTTATCGTTGCGCCAGCGGCGGGCATTCATTAAAGGCTCGCCATGATCA
AGCTTGCTTGAAGGCCCGCT

Downstream 100 bases:

>100_bases
TTCAGGCCCATCCAAACGCCGCCGATATCAGAAATGTGAACGTGATCGACTTCAATGAGTTAGAGCGGGATGGGGGCGAA
GGCCCGCGCACAATTTTCCT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEDGFHRLKPKAVILSGSPASTLDVGSPRAPSVIFESGL
PVFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCPLFEGLWSLGSRHQVWMSHGDRVTALPDGFEVVATSSNAPF
AFIADEKRRYYAVQFHPEVVHTPDGAKLIANFVHKIAGIKGDWTMSAYRAKAVEAIRNQVGDKKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIEVFEEEAGK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRVLGRELGLPDSFIGRHPFPG
PGLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MTQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEDGFHRLKPKAVILSGSPASTLDVGSPRAPSVIFESGL
PVFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCPLFEGLWSLGSRHQVWMSHGDRVTALPDGFEVVATSSNAPF
AFIADEKRRYYAVQFHPEVVHTPDGAKLIANFVHKIAGIKGDWTMSAYRAKAVEAIRNQVGDKKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIEVFEEEAGK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRVLGRELGLPDSFIGRHPFPG
PGLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_519_residues
TQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEDGFHRLKPKAVILSGSPASTLDVGSPRAPSVIFESGLP
VFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCPLFEGLWSLGSRHQVWMSHGDRVTALPDGFEVVATSSNAPFA
FIADEKRRYYAVQFHPEVVHTPDGAKLIANFVHKIAGIKGDWTMSAYRAKAVEAIRNQVGDKKVICALSGGVDSSVAALL
IHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIEVFEEEAGKL
GGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRVLGRELGLPDSFIGRHPFPGP
GLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADFY
HYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=36.0655737704918, Blast_Score=293, Evalue=4e-79,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=55.4285714285714, Blast_Score=599, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71992717, Length=574, Percent_Identity=36.411149825784, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=574, Percent_Identity=36.411149825784, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=36.411149825784, Blast_Score=278, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=51.3409961685824, Blast_Score=522, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=33.7568058076225, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57120; Mature: 56989

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEDGFHRLKPKAVILSGSP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCCEEEEECCC
ASTLDVGSPRAPSVIFESGLPVFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCP
CCCCCCCCCCCCCCEEECCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
LFEGLWSLGSRHQVWMSHGDRVTALPDGFEVVATSSNAPFAFIADEKRRYYAVQFHPEVV
HHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCEE
HTPDGAKLIANFVHKIAGIKGDWTMSAYRAKAVEAIRNQVGDKKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHVDASDRFIGELEGVSDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCH
TKRKIIGRLFIEVFEEEAGKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
ERMNMQLVEPLRELFKDEVRVLGRELGLPDSFIGRHPFPGPGLAIRCPGGISREKLEILR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQTAHPDTVLIVDFGSQVTQLIARRVRESGVYCEIVPFQSAEDGFHRLKPKAVILSGSP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCCEEEEECCC
ASTLDVGSPRAPSVIFESGLPVFGICYGQQTMCAQLGGKVESGHHREFGRAFLEVEKDCP
CCCCCCCCCCCCCCEEECCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
LFEGLWSLGSRHQVWMSHGDRVTALPDGFEVVATSSNAPFAFIADEKRRYYAVQFHPEVV
HHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCEE
HTPDGAKLIANFVHKIAGIKGDWTMSAYRAKAVEAIRNQVGDKKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFKEHYNLHLLHVDASDRFIGELEGVSDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCH
TKRKIIGRLFIEVFEEEAGKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
ERMNMQLVEPLRELFKDEVRVLGRELGLPDSFIGRHPFPGPGLAIRCPGGISREKLEILR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA