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The map label for this gene is arcA [H]

Identifier: 150398472

GI number: 150398472

Start: 3471960

End: 3472685

Strand: Reverse

Name: arcA [H]

Synonym: Smed_3280

Alternate gene names: 150398472

Gene position: 3472685-3471960 (Counterclockwise)

Preceding gene: 150398475

Following gene: 150398471

Centisome position: 91.82

GC content: 56.06

Gene sequence:

>726_bases
ATGCCGTCTGCAGAAGTGACTCGGCCCGTGATCGTAATCGTCGACGACGACCCGAATCTTCGCGGTTCTCTGGCAACTCT
GCTTGAAGCGAATGGTTTTTCTTCTCTGACGGCACAAGGCAGCGTCGAATTTTTCACCCTTGCTGAAAAACATCCGATTG
ACCTTGCTTTGGTCGATCTGCGTCTCAACGGGGAAAGCGGCCTTGCGCTGTCTATCCGTATCCGTGAGCATCATCGCATA
CCGATTGTCATGCTGACCGGGCAAGGCGACGAAACCGACAGGATCATCGGCTTGGAATCGAGCGCCGATGATTTCATCAT
GAAACCCTTTAACCCGCGCGAGCTTCTGGCCCGGCTGCGCGCCATATTGCGCCGCTCGGGTCACCCCGCGTTGGCAACGC
CGGACCGCAGCGCCAGACAGAGTAAACATTTTGGCAGGTTCAAGCTGAATCTGAACCGGCGCGAACTGATCGGTCCGGAT
GGGACCGAAATTTCTCTGACCAACGCCGAATACCGGTTGCTGGAATATTTCCTACACCATCCAGACCGGGTGATACCGCG
TGCCGAATTGATGGCGGAACTAGGAAACGACCTGTCGTTTTACATGGACCGCACCATTGACGTGCTGATCCTGCGGTTGC
GGCGCAAGATCGAGCAGGTGCCCTCCAAGCCCGTCCATTTGCAGACCCGGCGCGGACAAGGCTATATCTTCGTTGAGACA
TCATGA

Upstream 100 bases:

>100_bases
CGCATGCTCTAATAATTTACACCTTATTCTACTTCATAATTGGATCGTTAGGTGGAAGTATGTTTCGTCCCTCGTAGATC
TTACTTATGGGAGTGCTCGC

Downstream 100 bases:

>100_bases
CAGCGTTGCGGGTCCCGAACCGGCTTGGATCCCACGTTTCAGTGCGGTTGCGGCTGTGGCTGGCATTGGCGGCACTGGCA
CTTGCCACGCTGGTTGTCGG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MPSAEVTRPVIVIVDDDPNLRGSLATLLEANGFSSLTAQGSVEFFTLAEKHPIDLALVDLRLNGESGLALSIRIREHHRI
PIVMLTGQGDETDRIIGLESSADDFIMKPFNPRELLARLRAILRRSGHPALATPDRSARQSKHFGRFKLNLNRRELIGPD
GTEISLTNAEYRLLEYFLHHPDRVIPRAELMAELGNDLSFYMDRTIDVLILRLRRKIEQVPSKPVHLQTRRGQGYIFVET
S

Sequences:

>Translated_241_residues
MPSAEVTRPVIVIVDDDPNLRGSLATLLEANGFSSLTAQGSVEFFTLAEKHPIDLALVDLRLNGESGLALSIRIREHHRI
PIVMLTGQGDETDRIIGLESSADDFIMKPFNPRELLARLRAILRRSGHPALATPDRSARQSKHFGRFKLNLNRRELIGPD
GTEISLTNAEYRLLEYFLHHPDRVIPRAELMAELGNDLSFYMDRTIDVLILRLRRKIEQVPSKPVHLQTRRGQGYIFVET
S
>Mature_240_residues
PSAEVTRPVIVIVDDDPNLRGSLATLLEANGFSSLTAQGSVEFFTLAEKHPIDLALVDLRLNGESGLALSIRIREHHRIP
IVMLTGQGDETDRIIGLESSADDFIMKPFNPRELLARLRAILRRSGHPALATPDRSARQSKHFGRFKLNLNRRELIGPDG
TEISLTNAEYRLLEYFLHHPDRVIPRAELMAELGNDLSFYMDRTIDVLILRLRRKIEQVPSKPVHLQTRRGQGYIFVETS

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=37.2294372294372, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=41.0480349344978, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=36.3247863247863, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=35.8974358974359, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=35.3711790393013, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=37.5, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=32.4675324675325, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=34.4978165938865, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=30.7017543859649, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.061135371179, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=29.2576419213974, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=28.6919831223629, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=31.7596566523605, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789402, Length=237, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27249; Mature: 27118

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSAEVTRPVIVIVDDDPNLRGSLATLLEANGFSSLTAQGSVEFFTLAEKHPIDLALVDL
CCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEECCCCEEEEEECCCCCCEEEEEEE
RLNGESGLALSIRIREHHRIPIVMLTGQGDETDRIIGLESSADDFIMKPFNPRELLARLR
EECCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCEEECCCCHHHHHHHHH
AILRRSGHPALATPDRSARQSKHFGRFKLNLNRRELIGPDGTEISLTNAEYRLLEYFLHH
HHHHHCCCCCCCCCCCHHHHHCCCCEEEEECCHHEECCCCCCEEEEECHHHHHHHHHHHC
PDRVIPRAELMAELGNDLSFYMDRTIDVLILRLRRKIEQVPSKPVHLQTRRGQGYIFVET
CCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEE
S
C
>Mature Secondary Structure 
PSAEVTRPVIVIVDDDPNLRGSLATLLEANGFSSLTAQGSVEFFTLAEKHPIDLALVDL
CCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEECCCCEEEEEECCCCCCEEEEEEE
RLNGESGLALSIRIREHHRIPIVMLTGQGDETDRIIGLESSADDFIMKPFNPRELLARLR
EECCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCEEECCCCHHHHHHHHH
AILRRSGHPALATPDRSARQSKHFGRFKLNLNRRELIGPDGTEISLTNAEYRLLEYFLHH
HHHHHCCCCCCCCCCCHHHHHCCCCEEEEECCHHEECCCCCCEEEEECHHHHHHHHHHHC
PDRVIPRAELMAELGNDLSFYMDRTIDVLILRLRRKIEQVPSKPVHLQTRRGQGYIFVET
CCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEE
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]