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The map label for this gene is actR [H]

Identifier: 150398465

GI number: 150398465

Start: 3454265

End: 3454849

Strand: Reverse

Name: actR [H]

Synonym: Smed_3273

Alternate gene names: 150398465

Gene position: 3454849-3454265 (Counterclockwise)

Preceding gene: 150398466

Following gene: 150398463

Centisome position: 91.35

GC content: 62.56

Gene sequence:

>585_bases
ATGATCGAAAAGTCGACGCCTGCGCCAATCACCCACGCCGCGGATGCGGACCTGATCGGACCCGACAAGAGCCTTCTGAT
CGTCGATGACGACACCGCTTTTCTGCGGCGCCTCGCCCGCGCGATGGAAGCGCGCGGCTTCGCGGTAGAGATCGCCGAGT
CGGTTGCCGAAGGCATAGCCAAAGCCAAGACTCGGCCACCGAAACATGCAGTCATCGATCTCCGCCTTGGCGACGGCAGC
GGTCTCGACGTGATCGAGGCAATCCGCGGGCGTCGCGACGACACGCGGATGATCGTTCTAACGGGTTATGGTAATATCGC
GACCGCGGTCAACGCCGTGAAGCTCGGAGCGCTCGACTATCTGGCAAAACCGGCGGACGCCGATGACATTCTCGCAGCAT
TGATTCAGCGCCCGGGCGAACGGGTAGAGCCCCCGGAGAACCCCATGTCGGCGGACCGCGTCCGATGGGAGCATATCCAG
CGCGTCTACGAAATGTGCGAACGCAATGTTTCGGAAACGGCGCGCCGGCTAAACATGCACCGGCGGACCTTGCAGCGCAT
TCTGGCGAAACGGGCCCCGAAATAG

Upstream 100 bases:

>100_bases
TCCTTTGGTCCCACCGTTCAAAGGACATGCGGAAACTGTTACAGGTTACAGAAGCCATTGCGCGTCCGGCTGGACGCGCG
GCGCTGTAGGGGTTTGAGAA

Downstream 100 bases:

>100_bases
GCCGGCGGCGGATGAGGGGCAAATCTCGGGAGCGCTCTAGTCCCGCCCCCCGCTTACGATATCGCAGATCGACTGGCCGA
GCTCGCCATTCCGATCGGCT

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MIEKSTPAPITHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIAKAKTRPPKHAVIDLRLGDGS
GLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDYLAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQ
RVYEMCERNVSETARRLNMHRRTLQRILAKRAPK

Sequences:

>Translated_194_residues
MIEKSTPAPITHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIAKAKTRPPKHAVIDLRLGDGS
GLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDYLAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQ
RVYEMCERNVSETARRLNMHRRTLQRILAKRAPK
>Mature_194_residues
MIEKSTPAPITHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIAKAKTRPPKHAVIDLRLGDGS
GLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDYLAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQ
RVYEMCERNVSETARRLNMHRRTLQRILAKRAPK

Specific function: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response [H]

COG id: COG4567

COG function: function code TK; Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=30, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788550, Length=113, Percent_Identity=30.9734513274336, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=29.0322580645161, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21421; Mature: 21421

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKSTPAPITHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KAKTRPPKHAVIDLRLGDGSGLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDY
HHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQRVYEMCERNVSETARRLNMH
HCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RRTLQRILAKRAPK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MIEKSTPAPITHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KAKTRPPKHAVIDLRLGDGSGLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDY
HHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQRVYEMCERNVSETARRLNMH
HCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RRTLQRILAKRAPK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]