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The map label for this gene is regB [H]

Identifier: 150398466

GI number: 150398466

Start: 3455027

End: 3456328

Strand: Reverse

Name: regB [H]

Synonym: Smed_3274

Alternate gene names: 150398466

Gene position: 3456328-3455027 (Counterclockwise)

Preceding gene: 150398467

Following gene: 150398465

Centisome position: 91.39

GC content: 63.75

Gene sequence:

>1302_bases
ATGGCAGCCTCAACGCTCTACAATGACCTGAACAGCAATCGCAGCCTCAGACTTCAGACGCTCGTGCGGCTGCGCTGGCT
GGCGGTGGGCGGACAATTGCTAGCCGTTATCGTCACGGCGCTTTGGCTGCAGTTCCCCCTGCCGATCGTCCCCTGTTCGG
TTCTGATTGCCTGCCTGGCACTCGTCAACGTCATTCTCACATTGCGGTTTCCGCCTACGCAGCGGCTGACGCCGCCGGCC
GCTTTCGCCCTGCTCGGCCTGGATCTGGCGCAACTCACCGCCTTGCTCTTCATCACCGGCGGGCTTGCCAACCCCTTTGC
GCCGCTTCTCTGCGTTCCGGTCATCATCTCTTCGGCCTCGCAGCCGAAGCCTCACAGCATCGTGCTGGCCGTGTTTGCCG
TCGTGGGCGTCACCGCGCTCGCCTTCTCGCCCTTCCAGCTGCCCTGGTATCCGGGGACCGTTCTGCTGATCCCGCACGTG
CTGACGGCCGGCATCTGGTTCGCGATCGTCTCGATGACGGCGTTCGCAGCATTCTACACCTACCGTGTATCGCTCGAGGC
AAGCGAACTGTCAGAAGCGCTGACCGCCACCGAACTCGTGCTCCAGCGCGAAAAGCACCTGTCGCAACTCGACGGGCTCG
CAGCCGCCGCCGCGCACGAACTCGGAACGCCGCTTGCGACGATCAGCGTCGTAGCCAAGGAGATGGAACGGGAGCTCGGC
GACGATCCTCGTTTCGGCGAAGACGTCCACCTCCTGCGCAGCCAGAGCGAGCGCTGCCGAGACATACTGAGGCGGCTCAC
GACGCTTTCTTCGGAGAGCGAGGAACATATGCGACTTCTGCCGCTCTCGTCCCTTATCGAGGAGGTGATGGCGCCGCATC
GCGAATTCGGAATCGAAATCGAGCTGAAGGAGCAGGGCGAACGCGCCACGGAGCCCGTCGGCATCCGCAATGCAGGCATT
CTCTATGGCCTGGGAAACCTGCTGGAAAACGCGGTCGACTATGCGCGCAAGAAAGTGACGGTCACGACGGAGCACACGCC
CGAGCGCGTACGGGTGACGATCGAAGACGACGGCGAAGGTTTTTCGCCGGATATCCTGGCGCGGATCGGCGAACCCTATG
TGACGCGGCGTCAGAAGGACGACAGTGCCGGCGGGCTCGGGCTCGGGCTCTTCATCGCCAAGACGCTGCTCGAGCGTTCG
GGTGCCCGGCTGCGCTTCGAGAACGGTGGAGCCAAACACCCGGGTGCCCGGGTCAGCGTCGAATGGCCGCGCGCGCTGAT
GGACTCGAAACTGGCGAAATGA

Upstream 100 bases:

>100_bases
CGCGGCGCTTAACCCCATTTGATAATTGCCGGGTTCGGCATAAAGTTCGGTAGGACGAACTGATGCGGCCGCATGCGGCC
GCATCGCGGAATGGAAACGC

Downstream 100 bases:

>100_bases
CTTTTGGCAGTTTATTGAAGACAAGCGTGGGAAAACCCACATGACTGCCGGCAAAACAACAGCTTGCCGACTGCAGTTCC
TTTGGTCCCACCGTTCAAAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Protein prrB [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAASTLYNDLNSNRSLRLQTLVRLRWLAVGGQLLAVIVTALWLQFPLPIVPCSVLIACLALVNVILTLRFPPTQRLTPPA
AFALLGLDLAQLTALLFITGGLANPFAPLLCVPVIISSASQPKPHSIVLAVFAVVGVTALAFSPFQLPWYPGTVLLIPHV
LTAGIWFAIVSMTAFAAFYTYRVSLEASELSEALTATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELG
DDPRFGEDVHLLRSQSERCRDILRRLTTLSSESEEHMRLLPLSSLIEEVMAPHREFGIEIELKEQGERATEPVGIRNAGI
LYGLGNLLENAVDYARKKVTVTTEHTPERVRVTIEDDGEGFSPDILARIGEPYVTRRQKDDSAGGLGLGLFIAKTLLERS
GARLRFENGGAKHPGARVSVEWPRALMDSKLAK

Sequences:

>Translated_433_residues
MAASTLYNDLNSNRSLRLQTLVRLRWLAVGGQLLAVIVTALWLQFPLPIVPCSVLIACLALVNVILTLRFPPTQRLTPPA
AFALLGLDLAQLTALLFITGGLANPFAPLLCVPVIISSASQPKPHSIVLAVFAVVGVTALAFSPFQLPWYPGTVLLIPHV
LTAGIWFAIVSMTAFAAFYTYRVSLEASELSEALTATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELG
DDPRFGEDVHLLRSQSERCRDILRRLTTLSSESEEHMRLLPLSSLIEEVMAPHREFGIEIELKEQGERATEPVGIRNAGI
LYGLGNLLENAVDYARKKVTVTTEHTPERVRVTIEDDGEGFSPDILARIGEPYVTRRQKDDSAGGLGLGLFIAKTLLERS
GARLRFENGGAKHPGARVSVEWPRALMDSKLAK
>Mature_432_residues
AASTLYNDLNSNRSLRLQTLVRLRWLAVGGQLLAVIVTALWLQFPLPIVPCSVLIACLALVNVILTLRFPPTQRLTPPAA
FALLGLDLAQLTALLFITGGLANPFAPLLCVPVIISSASQPKPHSIVLAVFAVVGVTALAFSPFQLPWYPGTVLLIPHVL
TAGIWFAIVSMTAFAAFYTYRVSLEASELSEALTATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELGD
DPRFGEDVHLLRSQSERCRDILRRLTTLSSESEEHMRLLPLSSLIEEVMAPHREFGIEIELKEQGERATEPVGIRNAGIL
YGLGNLLENAVDYARKKVTVTTEHTPERVRVTIEDDGEGFSPDILARIGEPYVTRRQKDDSAGGLGLGLFIAKTLLERSG
ARLRFENGGAKHPGARVSVEWPRALMDSKLAK

Specific function: Member of the two-component regulatory system RegB/RegA. Involved in the positive regulation of photosynthesis gene expression in response to anaerobiosis. Also involved in positive regulation of the cbbI and cbbII Calvin cycle CO2 fixation operons, as we

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=208, Percent_Identity=26.9230769230769, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=26.4705882352941, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47212; Mature: 47080

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASTLYNDLNSNRSLRLQTLVRLRWLAVGGQLLAVIVTALWLQFPLPIVPCSVLIACLA
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVNVILTLRFPPTQRLTPPAAFALLGLDLAQLTALLFITGGLANPFAPLLCVPVIISSAS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
QPKPHSIVLAVFAVVGVTALAFSPFQLPWYPGTVLLIPHVLTAGIWFAIVSMTAFAAFYT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRVSLEASELSEALTATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELG
HEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DDPRFGEDVHLLRSQSERCRDILRRLTTLSSESEEHMRLLPLSSLIEEVMAPHREFGIEI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCHHHHCCEE
ELKEQGERATEPVGIRNAGILYGLGNLLENAVDYARKKVTVTTEHTPERVRVTIEDDGEG
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCC
FSPDILARIGEPYVTRRQKDDSAGGLGLGLFIAKTLLERSGARLRFENGGAKHPGARVSV
CCHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEE
EWPRALMDSKLAK
CCHHHHHHHHCCC
>Mature Secondary Structure 
AASTLYNDLNSNRSLRLQTLVRLRWLAVGGQLLAVIVTALWLQFPLPIVPCSVLIACLA
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVNVILTLRFPPTQRLTPPAAFALLGLDLAQLTALLFITGGLANPFAPLLCVPVIISSAS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
QPKPHSIVLAVFAVVGVTALAFSPFQLPWYPGTVLLIPHVLTAGIWFAIVSMTAFAAFYT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRVSLEASELSEALTATELVLQREKHLSQLDGLAAAAAHELGTPLATISVVAKEMERELG
HEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DDPRFGEDVHLLRSQSERCRDILRRLTTLSSESEEHMRLLPLSSLIEEVMAPHREFGIEI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCHHHHCCEE
ELKEQGERATEPVGIRNAGILYGLGNLLENAVDYARKKVTVTTEHTPERVRVTIEDDGEG
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCC
FSPDILARIGEPYVTRRQKDDSAGGLGLGLFIAKTLLERSGARLRFENGGAKHPGARVSV
CCHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEE
EWPRALMDSKLAK
CCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751278; 10358089 [H]