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The map label for this gene is hisE [H]

Identifier: 150398450

GI number: 150398450

Start: 3439147

End: 3439470

Strand: Reverse

Name: hisE [H]

Synonym: Smed_3258

Alternate gene names: 150398450

Gene position: 3439470-3439147 (Counterclockwise)

Preceding gene: 150398451

Following gene: 150398449

Centisome position: 90.95

GC content: 59.57

Gene sequence:

>324_bases
ATGACAGAGTTCACCCTCTCCGATCTGGAGAAGATCGTGGCGACCCGCGCCAGGGCGGCTCCGGAGGAGTCCTGGACTGC
CAAGCTGGTCGCTGCCGGACAGAAGAAGGCAGCCAAGAAGCTGGGAGAGGAAGCCGTCGAAACGGTCATCGCGGCGATCG
GCGATGACCGGAAGAATCTGGTCGATGAGAGTGCCGATCTCCTCTATCATCTTATGGTCGTATTGAATATCGCCGCCATC
CCGTTACAGGATGTGATGAGCGAACTGGCCAGGCGGACGAGCCAGTCCGGCCTGCAGGAAAAGGCGAACCGGCAGAATCC
ATGA

Upstream 100 bases:

>100_bases
TCACTTCGGAACATACAGCATCGGTGAGGCGAAGCGCCACATGGCCGAGCACGGCGTCGCCATGCGTCTCGATTGAAGCG
GCCACGAGAAGGGATAGACC

Downstream 100 bases:

>100_bases
GCATCGCCGCGAAAGACATCGAACCGGCCGACATTCCGGGCAATCTTCAGGGGGGCGAATATTCGCCCTATCACGTCTTC
TCCGCGGAGGAATGGTCGCG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MTEFTLSDLEKIVATRARAAPEESWTAKLVAAGQKKAAKKLGEEAVETVIAAIGDDRKNLVDESADLLYHLMVVLNIAAI
PLQDVMSELARRTSQSGLQEKANRQNP

Sequences:

>Translated_107_residues
MTEFTLSDLEKIVATRARAAPEESWTAKLVAAGQKKAAKKLGEEAVETVIAAIGDDRKNLVDESADLLYHLMVVLNIAAI
PLQDVMSELARRTSQSGLQEKANRQNP
>Mature_106_residues
TEFTLSDLEKIVATRARAAPEESWTAKLVAAGQKKAAKKLGEEAVETVIAAIGDDRKNLVDESADLLYHLMVVLNIAAIP
LQDVMSELARRTSQSGLQEKANRQNP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=87, Percent_Identity=47.1264367816092, Blast_Score=82, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 11660; Mature: 11529

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFTLSDLEKIVATRARAAPEESWTAKLVAAGQKKAAKKLGEEAVETVIAAIGDDRKNL
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VDESADLLYHLMVVLNIAAIPLQDVMSELARRTSQSGLQEKANRQNP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEFTLSDLEKIVATRARAAPEESWTAKLVAAGQKKAAKKLGEEAVETVIAAIGDDRKNL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VDESADLLYHLMVVLNIAAIPLQDVMSELARRTSQSGLQEKANRQNP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]