Click here to switch to the map view.

The map label for this gene is divL [H]

Identifier: 150398438

GI number: 150398438

Start: 3425870

End: 3428350

Strand: Reverse

Name: divL [H]

Synonym: Smed_3246

Alternate gene names: 150398438

Gene position: 3428350-3425870 (Counterclockwise)

Preceding gene: 150398439

Following gene: 150398437

Centisome position: 90.65

GC content: 63.4

Gene sequence:

>2481_bases
GTGAAAACACATCTATCCAGGACTTCTGCAAAACGGCAGGGGGCGCCGAGACTCATAAGGCGGCTCCTTGCGGGGACGGT
ACTGCTCACGGCAAGCGATGCCGCTGCTCAGGCCGCCGGCCCGGCCAGAAGCATATTCGGCACCCCCGAGGTCGTCACCT
TCTCCGTGCTTATCGGGGTCATTTCCGCCGCCATGATTTCGGCGATCTGGCTCATCCGCCAGCGCGGAAACATAGAGGCC
GAGAACCGCGATCTTCGCTCCAGCCTGTCCGACGCGAACCAGCATATTTCCCGCTTTCAGGCGCTAATCGCCGACAAGAA
CAGGCGTATCGTGATCTGGGACGGGCTCGCAGATCGAGCCGAGTTCCTGGGGCATCTCCCGGTGGAGACCGGCGCACCAC
AGGACGACCGCGACTTTCTCGCCTTCGGCCGCTGGGTCAAGCCGCATTCGGCGGGGCAGCTCGAAAAAGCGATCGAGGCT
CTGCGCGCCCAGGCGCAAAGCTTCGACCTCGTGCTCGAGACCCAGCGCAACGAGGTCCTCGAGGCTCAGGGCCGCGTGTC
GGGCGGGCGGGCCTTCGTTCGCTTCATCGCGCTCAACAATCTCAGGGCAGAGCTCGCCGAACTGAAGCTCGAACGCGACC
AGCTGCACGCGTCCCTTTCAACATTCCGGACGCTGCTCGACGCGGTCGACCTTCCCGCCTGGCAGCGCGCAGGAGACGGC
AGGCTCGAATGGGTCAACGCCGCCTATGCCAAGGCGGTGGAAACCCCGAGTGCGAGCCTTGCGGTCGCCGAAGAGAGGGA
GCTGCTCGCGACGGCGGCTCGCGACCGGATCAGGGCGGTCGCGACCCTGCAGACGCCGTTCCGCGACAAGGTTTCCACAG
TTGTGAGGGGCAACAGGACGTTCTTCGACGTCGTGGACGCCCGCACGCCGGCCGGCTCGGCTGGCATCGCGATCGACGTC
TCCGGTATCGAAGCGGTGCGCGAGGAACTGGCCAGGACGCTCAAGAGCCATGCCGAAACGCTCGAGCACCTGGCAACGCC
GGTGGCGATCTTCGACGGCAACCAGCGCCTGCAGTTCTACAATCAGGCATTCCAGCGGCTTTGGGATCTGGATATGGGAT
TCCTCGAGCGTAAGCCGGACAATGGCGAGATGTTCGACCGCCTGCGCGACGGCGGCAAGCTGCCGGAGCAGCTCAATTGG
AAACAATGGAAGGCGAATGCGCTTTCCGTCTATCAGGCGCTCGACACCCAGACCGATCTCTGGCACCTGCCGAACGGCCA
GACGCTGCGCGTTTTCGCGACCGCACGGCCGCAGGGCGGCGCCACCTGGGTCTTCGAGAACCTGACGGAGAAGGTCGACC
TCGAAACGCGGTATAACACGCTGGTCCAGGTCCAGGGCGAAACGATCGATCATCTCGCCGAGGGCGTCGCCGTTTTCGGA
CCGGACGGCCGCATACGGTTGTCGAACCCGGCCTTCCGGGCGATCTGGGGCATCAACGAGACCGAGGCCCAGCCCGGCAC
CCATATACGAGCGATCGAGCAGGCGTGCCTTGCTTCCTATGACCAGCAGGACGGCTGGAAGCGCTTCGCCCATATCATCA
CCAGCTTCGATGATGAGCGGCCGTCGAGCCGCGGGATCCTGGAACTGCGCACCGGGCTGATCCTTGATTACGCGGTCATT
CCGCTTCCGAACGCCCAGACGATGCTGACCTTCGTCAATATCACCGACAGCGTCCGCGTCGAGCGTGCGCTGACCGAGAA
GAACGAAGCGCTGCGCAAGGCGGACGCGCTGAAGAACGATTTCGTGCACCATGTTTCCTACGAGCTGCGCTCGCCGCTGA
CGAACATCATCGGTTTCGCCGACCTTCTGAAAACGCCGGTCTTCGGCGAACTCAACGAGCGCCAGGCGGAATATGTCGAT
CACATCGCCACCTCTTCGTCGCTGCTTCTGACGATCGTCAACGACATTCTCGATCTCGCGACCGTCGATGCCGGTATCGT
CGAGCTCGAGCTGGCCGAGGTGAACCTCATCGACCTCATCGACGACGTGACCCAGCAGATGGGCGATCGCCTGGTGGAGA
GCGGCGTGTCGCTTCGAACCGATGCACCCGACAATCTCGGCCGAATCACCGCCGATCAGCAACGGCTAAAGCAGATTTTC
ATAAAGCTACTGACCAATGCCGCGAATTTCGCGCCCGACGGGAGCACGATCGAGCTCAAATGCTGGCGCGAGGGGAGCGA
CTTTGCCTTTTCCGTCACCGACACCGGGCCGGGCATCCCGCAGGACGTGCTCAACACCGTCTTCAACCGCTTCGAAAGCT
ACGGCCAACGCGGCGGCGCCGGTCTGGGCCTCTCCATCGTCGAGAGCTTCGTCAGCCTTCACCACGGCAACGTGTCGATC
CGCAGCAAGGAGGGTGAGGGCACCGAAGTCACCTGCCGCATTCCCTCCGCTCAAGCGCCGAAGGTCATTGCGGCGGAATA
G

Upstream 100 bases:

>100_bases
GACCGGAGATGGAATCGGAACTGACAGGGACCTTTGAACGGGTTCCGGCGCGCGGGGGCGCAAGGTCGCCGGCAATTTCC
GGACGAACGGGGACGGCGCC

Downstream 100 bases:

>100_bases
ATGTGATAAATGAAGTCGCTAGAATGCCTGCTGACGGACGAGGCCGCCACCAACGAATTCGGCGAGGACCTCGCATTGGC
GCTGAAAGCCGGCGATTGCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 826; Mature: 826

Protein sequence:

>826_residues
MKTHLSRTSAKRQGAPRLIRRLLAGTVLLTASDAAAQAAGPARSIFGTPEVVTFSVLIGVISAAMISAIWLIRQRGNIEA
ENRDLRSSLSDANQHISRFQALIADKNRRIVIWDGLADRAEFLGHLPVETGAPQDDRDFLAFGRWVKPHSAGQLEKAIEA
LRAQAQSFDLVLETQRNEVLEAQGRVSGGRAFVRFIALNNLRAELAELKLERDQLHASLSTFRTLLDAVDLPAWQRAGDG
RLEWVNAAYAKAVETPSASLAVAEERELLATAARDRIRAVATLQTPFRDKVSTVVRGNRTFFDVVDARTPAGSAGIAIDV
SGIEAVREELARTLKSHAETLEHLATPVAIFDGNQRLQFYNQAFQRLWDLDMGFLERKPDNGEMFDRLRDGGKLPEQLNW
KQWKANALSVYQALDTQTDLWHLPNGQTLRVFATARPQGGATWVFENLTEKVDLETRYNTLVQVQGETIDHLAEGVAVFG
PDGRIRLSNPAFRAIWGINETEAQPGTHIRAIEQACLASYDQQDGWKRFAHIITSFDDERPSSRGILELRTGLILDYAVI
PLPNAQTMLTFVNITDSVRVERALTEKNEALRKADALKNDFVHHVSYELRSPLTNIIGFADLLKTPVFGELNERQAEYVD
HIATSSSLLLTIVNDILDLATVDAGIVELELAEVNLIDLIDDVTQQMGDRLVESGVSLRTDAPDNLGRITADQQRLKQIF
IKLLTNAANFAPDGSTIELKCWREGSDFAFSVTDTGPGIPQDVLNTVFNRFESYGQRGGAGLGLSIVESFVSLHHGNVSI
RSKEGEGTEVTCRIPSAQAPKVIAAE

Sequences:

>Translated_826_residues
MKTHLSRTSAKRQGAPRLIRRLLAGTVLLTASDAAAQAAGPARSIFGTPEVVTFSVLIGVISAAMISAIWLIRQRGNIEA
ENRDLRSSLSDANQHISRFQALIADKNRRIVIWDGLADRAEFLGHLPVETGAPQDDRDFLAFGRWVKPHSAGQLEKAIEA
LRAQAQSFDLVLETQRNEVLEAQGRVSGGRAFVRFIALNNLRAELAELKLERDQLHASLSTFRTLLDAVDLPAWQRAGDG
RLEWVNAAYAKAVETPSASLAVAEERELLATAARDRIRAVATLQTPFRDKVSTVVRGNRTFFDVVDARTPAGSAGIAIDV
SGIEAVREELARTLKSHAETLEHLATPVAIFDGNQRLQFYNQAFQRLWDLDMGFLERKPDNGEMFDRLRDGGKLPEQLNW
KQWKANALSVYQALDTQTDLWHLPNGQTLRVFATARPQGGATWVFENLTEKVDLETRYNTLVQVQGETIDHLAEGVAVFG
PDGRIRLSNPAFRAIWGINETEAQPGTHIRAIEQACLASYDQQDGWKRFAHIITSFDDERPSSRGILELRTGLILDYAVI
PLPNAQTMLTFVNITDSVRVERALTEKNEALRKADALKNDFVHHVSYELRSPLTNIIGFADLLKTPVFGELNERQAEYVD
HIATSSSLLLTIVNDILDLATVDAGIVELELAEVNLIDLIDDVTQQMGDRLVESGVSLRTDAPDNLGRITADQQRLKQIF
IKLLTNAANFAPDGSTIELKCWREGSDFAFSVTDTGPGIPQDVLNTVFNRFESYGQRGGAGLGLSIVESFVSLHHGNVSI
RSKEGEGTEVTCRIPSAQAPKVIAAE
>Mature_826_residues
MKTHLSRTSAKRQGAPRLIRRLLAGTVLLTASDAAAQAAGPARSIFGTPEVVTFSVLIGVISAAMISAIWLIRQRGNIEA
ENRDLRSSLSDANQHISRFQALIADKNRRIVIWDGLADRAEFLGHLPVETGAPQDDRDFLAFGRWVKPHSAGQLEKAIEA
LRAQAQSFDLVLETQRNEVLEAQGRVSGGRAFVRFIALNNLRAELAELKLERDQLHASLSTFRTLLDAVDLPAWQRAGDG
RLEWVNAAYAKAVETPSASLAVAEERELLATAARDRIRAVATLQTPFRDKVSTVVRGNRTFFDVVDARTPAGSAGIAIDV
SGIEAVREELARTLKSHAETLEHLATPVAIFDGNQRLQFYNQAFQRLWDLDMGFLERKPDNGEMFDRLRDGGKLPEQLNW
KQWKANALSVYQALDTQTDLWHLPNGQTLRVFATARPQGGATWVFENLTEKVDLETRYNTLVQVQGETIDHLAEGVAVFG
PDGRIRLSNPAFRAIWGINETEAQPGTHIRAIEQACLASYDQQDGWKRFAHIITSFDDERPSSRGILELRTGLILDYAVI
PLPNAQTMLTFVNITDSVRVERALTEKNEALRKADALKNDFVHHVSYELRSPLTNIIGFADLLKTPVFGELNERQAEYVD
HIATSSSLLLTIVNDILDLATVDAGIVELELAEVNLIDLIDDVTQQMGDRLVESGVSLRTDAPDNLGRITADQQRLKQIF
IKLLTNAANFAPDGSTIELKCWREGSDFAFSVTDTGPGIPQDVLNTVFNRFESYGQRGGAGLGLSIVESFVSLHHGNVSI
RSKEGEGTEVTCRIPSAQAPKVIAAE

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=33.969465648855, Blast_Score=126, Evalue=6e-30,
Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=32.1138211382114, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=29.0836653386454, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=30.8333333333333, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=27.1062271062271, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=27.2340425531915, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=26.7399267399267, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=293, Percent_Identity=25.938566552901, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1790436, Length=270, Percent_Identity=28.5185185185185, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=28.8702928870293, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=25.9414225941423, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=22.9787234042553, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91192; Mature: 91192

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50109 HIS_KIN ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHLSRTSAKRQGAPRLIRRLLAGTVLLTASDAAAQAAGPARSIFGTPEVVTFSVLIGV
CCCCCCHHHHHHCCCHHHHHHHHHCEEEEEECCHHHHCCCCHHHHCCCCHHHHHHHHHHH
ISAAMISAIWLIRQRGNIEAENRDLRSSLSDANQHISRFQALIADKNRRIVIWDGLADRA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
EFLGHLPVETGAPQDDRDFLAFGRWVKPHSAGQLEKAIEALRAQAQSFDLVLETQRNEVL
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCHHHHH
EAQGRVSGGRAFVRFIALNNLRAELAELKLERDQLHASLSTFRTLLDAVDLPAWQRAGDG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
RLEWVNAAYAKAVETPSASLAVAEERELLATAARDRIRAVATLQTPFRDKVSTVVRGNRT
CEEEHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
FFDVVDARTPAGSAGIAIDVSGIEAVREELARTLKSHAETLEHLATPVAIFDGNQRLQFY
EEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
NQAFQRLWDLDMGFLERKPDNGEMFDRLRDGGKLPEQLNWKQWKANALSVYQALDTQTDL
HHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCE
WHLPNGQTLRVFATARPQGGATWVFENLTEKVDLETRYNTLVQVQGETIDHLAEGVAVFG
EECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCHHHCCEEEEECCCHHHHHHCCEEEEC
PDGRIRLSNPAFRAIWGINETEAQPGTHIRAIEQACLASYDQQDGWKRFAHIITSFDDER
CCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PSSRGILELRTGLILDYAVIPLPNAQTMLTFVNITDSVRVERALTEKNEALRKADALKND
CCCCCHHHHHHHHEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
FVHHVSYELRSPLTNIIGFADLLKTPVFGELNERQAEYVDHIATSSSLLLTIVNDILDLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TVDAGIVELELAEVNLIDLIDDVTQQMGDRLVESGVSLRTDAPDNLGRITADQQRLKQIF
HCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHH
IKLLTNAANFAPDGSTIELKCWREGSDFAFSVTDTGPGIPQDVLNTVFNRFESYGQRGGA
HHHHHHHHCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
GLGLSIVESFVSLHHGNVSIRSKEGEGTEVTCRIPSAQAPKVIAAE
CCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCEECC
>Mature Secondary Structure
MKTHLSRTSAKRQGAPRLIRRLLAGTVLLTASDAAAQAAGPARSIFGTPEVVTFSVLIGV
CCCCCCHHHHHHCCCHHHHHHHHHCEEEEEECCHHHHCCCCHHHHCCCCHHHHHHHHHHH
ISAAMISAIWLIRQRGNIEAENRDLRSSLSDANQHISRFQALIADKNRRIVIWDGLADRA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
EFLGHLPVETGAPQDDRDFLAFGRWVKPHSAGQLEKAIEALRAQAQSFDLVLETQRNEVL
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCHHHHH
EAQGRVSGGRAFVRFIALNNLRAELAELKLERDQLHASLSTFRTLLDAVDLPAWQRAGDG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
RLEWVNAAYAKAVETPSASLAVAEERELLATAARDRIRAVATLQTPFRDKVSTVVRGNRT
CEEEHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
FFDVVDARTPAGSAGIAIDVSGIEAVREELARTLKSHAETLEHLATPVAIFDGNQRLQFY
EEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
NQAFQRLWDLDMGFLERKPDNGEMFDRLRDGGKLPEQLNWKQWKANALSVYQALDTQTDL
HHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCE
WHLPNGQTLRVFATARPQGGATWVFENLTEKVDLETRYNTLVQVQGETIDHLAEGVAVFG
EECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCHHHCCEEEEECCCHHHHHHCCEEEEC
PDGRIRLSNPAFRAIWGINETEAQPGTHIRAIEQACLASYDQQDGWKRFAHIITSFDDER
CCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PSSRGILELRTGLILDYAVIPLPNAQTMLTFVNITDSVRVERALTEKNEALRKADALKND
CCCCCHHHHHHHHEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
FVHHVSYELRSPLTNIIGFADLLKTPVFGELNERQAEYVDHIATSSSLLLTIVNDILDLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TVDAGIVELELAEVNLIDLIDDVTQQMGDRLVESGVSLRTDAPDNLGRITADQQRLKQIF
HCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHH
IKLLTNAANFAPDGSTIELKCWREGSDFAFSVTDTGPGIPQDVLNTVFNRFESYGQRGGA
HHHHHHHHCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
GLGLSIVESFVSLHHGNVSIRSKEGEGTEVTCRIPSAQAPKVIAAE
CCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]