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The map label for this gene is ahcY [H]

Identifier: 150398439

GI number: 150398439

Start: 3428654

End: 3430054

Strand: Reverse

Name: ahcY [H]

Synonym: Smed_3247

Alternate gene names: 150398439

Gene position: 3430054-3428654 (Counterclockwise)

Preceding gene: 150398440

Following gene: 150398438

Centisome position: 90.7

GC content: 61.24

Gene sequence:

>1401_bases
ATGAGCGCAAATCAGGACTATATCGTCGCCGACATCGGACTTGCCGATTTCGGCCGCAAGGAAATTGCCATCGCAGAAAC
GGAAATGCCTGGTCTGATGGCCTGCCGTGAGGAGTTCGGTGCATCGAAGCCGCTGAAGGGCGCACGCATCACCGGCTCGC
TCCACATGACGATCCAGACCGCGGTGCTGATCGAGACGCTGGTCGCTCTCGGTGCCGAAGTGCGTTGGGCGTCGTGCAAC
ATCTTCTCGACACAGGACCACGCCGCAGCCGCGATCGCCGCGAGCGGCGTTCCCGTTTTCGCCGTCAAGGGTGAGACGCT
CGAGGAATACTGGACCTATACCGACAAGATCTTCCAGTGGGCCGATGGCGGCGTCTCGAACATGATCCTCGACGACGGCG
GCGACGCGACCATGTATATCCTGCTCGGCGCCCGCGCCGAGGCAGGCGAGAACATTCTGATCAATCCGGGCTCCGAAGAG
GAAGAGATCCTTTTCGCACAGATCAAGAAGCGCCTCGCCGCGACGCCCGGCTGGTTCACCAAGCAGCGCGACGCGATCAA
AGGCGTGACGGAAGAGACGACGACCGGCGTCAACCGCCTGTACCAGCTCCAGGCCAAGGGCCTGCTGCCCTTCCCGGCGA
TCAACGTCAACGACAGCGTCACCAAGTCCAAGTTCGACAACAAATACGGCTGTAAGGAATCGCTCGTCGACGGCATCCGC
CGCGGTACCGACGTGATGATGGCCGGCAAGGTCGCGGTGGTCTGCGGCTACGGCGACGTCGGCAAGGGCTCGGCCGCTTC
GCTCAGCGGCGCCGGCGCACGCGTCAAGGTCACTGAAGTGGACCCGATCTGCGCCCTCCAGGCGGCCATGGACGGCTACG
AAGTCGTTCAGCTCGAAGACGTCGTATCATCAGCGGACATCTTCATCACCACGACCGGCAACAAGGACGTCATCCGCATC
GAGCACATGCGCGCGATGAAGGACATGGCGATCGTCGGCAATATCGGTCACTTCGACAACGAGATCCAGGTATCGGCGCT
CCGTAACCTGAAGTGGACAAACGTCAAGCCGCAGGTCGATCTCATCGAGTTCCCGAAGGGCAATCGCATCATCCTGCTTT
CGGAAGGCCGTCTGCTCAACCTCGGCAACGCCACCGGACATCCGTCCTTCGTCATGTCGGCTTCCTTCTCCAACCAGGTT
CTGGCGCAGATCGAGCTCTTCACGAAGGGCGAGAACTACAAGAACGAGGTTTACGTGCTGCCGAAGCAGCTCGACGAGAA
GGTGGCGCGACTGCATCTCGCCAAACTCGGCGCGAAGCTGACCGAGCTTTCGGAGGAACAGGCCGCCTATATCGGCGTGA
AGGCGCAGGGTCCGTTCAAGGCCGAACACTACCGGTACTAA

Upstream 100 bases:

>100_bases
TGATAGACCGAAGCCACGCTGCCCGCAACCGCGGGAGGCATTGTCACGCCGCCGAACGGCCATGGGGCCGCGCGGTCCTA
GGATAAGCCTGGAGAACTTC

Downstream 100 bases:

>100_bases
TCCTTACCCGGGCAATCCACAACATGTTGTGGCCGCGATCTTGACAAGAGATCGCGGCCGCTTTTTTGGGCCGCACACTT
TCAGCCGAATCGTCAAAGAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCN
IFSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQWADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEE
EEILFAQIKKRLAATPGWFTKQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLEDVVSSADIFITTTGNKDVIRI
EHMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQV
LAQIELFTKGENYKNEVYVLPKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY

Sequences:

>Translated_466_residues
MSANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCN
IFSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQWADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEE
EEILFAQIKKRLAATPGWFTKQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLEDVVSSADIFITTTGNKDVIRI
EHMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQV
LAQIELFTKGENYKNEVYVLPKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY
>Mature_465_residues
SANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQTAVLIETLVALGAEVRWASCNI
FSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQWADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEEE
EILFAQIKKRLAATPGWFTKQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRR
GTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLEDVVSSADIFITTTGNKDVIRIE
HMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVDLIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQVL
AQIELFTKGENYKNEVYVLPKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=58.3333333333333, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.1818181818182, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=50.4291845493562, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=50.8583690987124, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=50.4291845493562, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=50.8583690987124, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=48.9270386266094, Blast_Score=433, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.7849462365591, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=484, Percent_Identity=57.4380165289256, Blast_Score=498, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=61.038961038961, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=467, Percent_Identity=51.1777301927195, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.755939524838, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.6493506493506, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50536; Mature: 50405

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQT
CCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEHHH
AVLIETLVALGAEVRWASCNIFSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQW
HHHHHHHHHCCCCEEEEEEEEECCCCCHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHH
ADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEEEEILFAQIKKRLAATPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLED
CCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEHH
VVSSADIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVD
HHCCCCEEEEECCCCCEEEEHHHHHHHHHEEEECCCCCCCEEEEEEHHCCEECCCCCCEE
LIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQVLAQIELFTKGENYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEEE
PKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SANQDYIVADIGLADFGRKEIAIAETEMPGLMACREEFGASKPLKGARITGSLHMTIQT
CCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEHHH
AVLIETLVALGAEVRWASCNIFSTQDHAAAAIAASGVPVFAVKGETLEEYWTYTDKIFQW
HHHHHHHHHCCCCEEEEEEEEECCCCCHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHH
ADGGVSNMILDDGGDATMYILLGARAEAGENILINPGSEEEEILFAQIKKRLAATPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDAIKGVTEETTTGVNRLYQLQAKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAASLSGAGARVKVTEVDPICALQAAMDGYEVVQLED
CCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEHH
VVSSADIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVSALRNLKWTNVKPQVD
HHCCCCEEEEECCCCCEEEEHHHHHHHHHEEEECCCCCCCEEEEEEHHCCEECCCCCCEE
LIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFSNQVLAQIELFTKGENYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEEE
PKQLDEKVARLHLAKLGAKLTELSEEQAAYIGVKAQGPFKAEHYRY
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA