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The map label for this gene is dcp [H]

Identifier: 150398369

GI number: 150398369

Start: 3340859

End: 3342922

Strand: Reverse

Name: dcp [H]

Synonym: Smed_3177

Alternate gene names: 150398369

Gene position: 3342922-3340859 (Counterclockwise)

Preceding gene: 150398372

Following gene: 150398367

Centisome position: 88.39

GC content: 62.06

Gene sequence:

>2064_bases
ATGAACGACATCGCTTCGCTCAACCCCGCCCTCGTGAACTGGACCGGACATGAGGGGCTGCCCCGGTTCGAGGCGGTAAG
GGACGAGGATTTCGGACCTGCCTTCGATGCGGCGCTTGCCGCCCATGAGGCGGAGATCGACGCTATCGCCCGTAATGCGG
AACCCCCAAGTTTCGGGAATACCGTCGTGGCGCTGGAAATCGCCGGGGATGAGCTGTCTCGCGTCTCCGCGCTCTTCTGG
AGCAAGGCGGGAGCCCACACGAACGAAACGATCCAGGCACTGGAGCGCGAGATCGCGCCCAAGATGTCGCGTCATTATTC
GAAAATCGGCACAAACCCAGCCCTCTTCAGCCGGATCGACGCGCTATGGGAGCGCCGGGAAGACCTCGGGCTCGATGTCG
AGGCCATGCGCGTTCTGGAGCGGCACTGGAAGAGCTTCGTCAAGTCGGGTGCCAAGCTCGATAAGGCCGATCAGGACCGC
CTCGCGGCAATCAACGAGAAGCTCGCCAGCCTCGGGGCGCGGTTTGGCCAGAATGTTCTCGCGGACGAGAAGGCCTGGGC
GCTGCTGCTGTCGAGCGAAGAGGAACTGGCAGGGATTCCTGATTTTCTGCGTGATGCTATGGCGGCTGCGGCGCGCGAGC
GCGGCGAGGAAGATAAGTATGCGGTCACGCTGTCTCGCTCGATTATCGAGCCTTTCCTGACTTTCTCCGAAATACGAGAG
TTGCGTGAGCAGGCGTTCAGGGCATGGGCGGCGCGCGGCGAAAATGGCGGCGAAACCGACAATCGCGGCATCATCGGCGA
AACGCTGTCTCTGCGGGCGGAGAAGGCCGAGCTGCTCGGCTACGAGAACTACGCGGCACTGAAGCTCGACAACACCATGG
CGAAGACTCCCGACGCCGTGAACGGCCTGCTGATGCAGGTTTGGGAAAAGGCCGTGGCGCGTGCCCGGGAAGAGGAGGCG
GACCTCGCCCGGCTGATCGCGGAAGAGGGCCGCAACCACGAGGTCATGCCCTGGGACTGGCGCCACTATGCGGAAAAACT
CAGGGCGCAGAGGTTCAGCTTTTCGGAAAGCGAACTGAAACCTTATCTGCAGCTCGAGAAGATCATCGATGCCTGTTTCG
CTATCGGCAAGCGCCTCTTCGGCCTCACCGCAGTCGAGAAGAAGGGCATTCCCGCCTATCACCCCGATGTGCGCGTCTAC
GAGATCCGCGACGCCTCCGGCAAGCTTACGGCGCTTTTCCTCGGCGATTACTTCGCGCGTCCCTCCAAGCGCTCCGGAGC
CTGGATGAGCTCATTTCAGTCGCAGCACAGGCTGGCGCTCAAGAATGGCGAAACCGGCGAGATCCCGATCGTCTACAATG
TCTGCAACTTCGCGAAGCCCGCAGAAGGCAAGCCGGCTCTGCTCTCGATCGATGACGCCCGCACGCTCTTCCACGAATTC
GGTCATGCGCTGCACGGCATGCTTTCAAACGTCACCTATCCGTCCGTTTCGGGCACCGGTGTCGCACGTGATTTCGTCGA
ACTGCCGTCGCAGCTTTACGAACATTGGCTGACGGTGCCGGAGGTCCTGCGGACCTATGCGGTGCATTACCGGACCGGTG
AACCCATGCCGCAGGCATTGCTCGACAAGGTGCTGGCGGCAAGGACGTTCAATTCAGGCTTCGCTACCGTCGAGTTCACC
GCTTCGGCGCTCGTCGACATGGCCTATCACACGACGGAAGGGGTTGGCGATCCGATGGCGCTCGAGAAGGCGACGCTGGA
TAAGATCGGCCTGCCCAAATCGATCGTGATGCGCCACCGCAGCCCGCATTTCCTGCATGTCTTCTCCGGCGACGGTTACT
CGGCCGGCTATTACTCCTACATGTGGTCGGAGGTGCTGGACGCCGACGCCTTTGCAGCCTTCGAGGAGACCGGCGATCCC
TTCGACCCGGCGACGGCGGCGAGATTGAAGGACAACATCTATTCGGTCGGCGGCTCCGTCGATCCGGAAGACGCCTACAA
GGCTTTCCGCGGCAAGCTGCCGAGCCCTGAAGCGATGCTGGGCAAGAGGGGGCTTGCGGCTTAG

Upstream 100 bases:

>100_bases
AATTCTGTCCGCGCAAGCTTGACGCTCCTGTTCCGAGCGACCACTTCAAGCGCCTGCCTTGCGGTTCTCCGCCGCTCGTC
CGCCTTCGAAAGGAAACTTG

Downstream 100 bases:

>100_bases
AAGGGACTCGCGCGACGCCCGTTCGCCCCGAGTATACGGCCGGTGTTTAGGGGCAAAGCGAGTGCCGCTTGTCCCTTCGC
CCCGCTTGCGGGGAGAAGGT

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MNDIASLNPALVNWTGHEGLPRFEAVRDEDFGPAFDAALAAHEAEIDAIARNAEPPSFGNTVVALEIAGDELSRVSALFW
SKAGAHTNETIQALEREIAPKMSRHYSKIGTNPALFSRIDALWERREDLGLDVEAMRVLERHWKSFVKSGAKLDKADQDR
LAAINEKLASLGARFGQNVLADEKAWALLLSSEEELAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSEIRE
LREQAFRAWAARGENGGETDNRGIIGETLSLRAEKAELLGYENYAALKLDNTMAKTPDAVNGLLMQVWEKAVARAREEEA
DLARLIAEEGRNHEVMPWDWRHYAEKLRAQRFSFSESELKPYLQLEKIIDACFAIGKRLFGLTAVEKKGIPAYHPDVRVY
EIRDASGKLTALFLGDYFARPSKRSGAWMSSFQSQHRLALKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPEVLRTYAVHYRTGEPMPQALLDKVLAARTFNSGFATVEFT
ASALVDMAYHTTEGVGDPMALEKATLDKIGLPKSIVMRHRSPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDP
FDPATAARLKDNIYSVGGSVDPEDAYKAFRGKLPSPEAMLGKRGLAA

Sequences:

>Translated_687_residues
MNDIASLNPALVNWTGHEGLPRFEAVRDEDFGPAFDAALAAHEAEIDAIARNAEPPSFGNTVVALEIAGDELSRVSALFW
SKAGAHTNETIQALEREIAPKMSRHYSKIGTNPALFSRIDALWERREDLGLDVEAMRVLERHWKSFVKSGAKLDKADQDR
LAAINEKLASLGARFGQNVLADEKAWALLLSSEEELAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSEIRE
LREQAFRAWAARGENGGETDNRGIIGETLSLRAEKAELLGYENYAALKLDNTMAKTPDAVNGLLMQVWEKAVARAREEEA
DLARLIAEEGRNHEVMPWDWRHYAEKLRAQRFSFSESELKPYLQLEKIIDACFAIGKRLFGLTAVEKKGIPAYHPDVRVY
EIRDASGKLTALFLGDYFARPSKRSGAWMSSFQSQHRLALKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPEVLRTYAVHYRTGEPMPQALLDKVLAARTFNSGFATVEFT
ASALVDMAYHTTEGVGDPMALEKATLDKIGLPKSIVMRHRSPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDP
FDPATAARLKDNIYSVGGSVDPEDAYKAFRGKLPSPEAMLGKRGLAA
>Mature_687_residues
MNDIASLNPALVNWTGHEGLPRFEAVRDEDFGPAFDAALAAHEAEIDAIARNAEPPSFGNTVVALEIAGDELSRVSALFW
SKAGAHTNETIQALEREIAPKMSRHYSKIGTNPALFSRIDALWERREDLGLDVEAMRVLERHWKSFVKSGAKLDKADQDR
LAAINEKLASLGARFGQNVLADEKAWALLLSSEEELAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSEIRE
LREQAFRAWAARGENGGETDNRGIIGETLSLRAEKAELLGYENYAALKLDNTMAKTPDAVNGLLMQVWEKAVARAREEEA
DLARLIAEEGRNHEVMPWDWRHYAEKLRAQRFSFSESELKPYLQLEKIIDACFAIGKRLFGLTAVEKKGIPAYHPDVRVY
EIRDASGKLTALFLGDYFARPSKRSGAWMSSFQSQHRLALKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPEVLRTYAVHYRTGEPMPQALLDKVLAARTFNSGFATVEFT
ASALVDMAYHTTEGVGDPMALEKATLDKIGLPKSIVMRHRSPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDP
FDPATAARLKDNIYSVGGSVDPEDAYKAFRGKLPSPEAMLGKRGLAA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=604, Percent_Identity=30.4635761589404, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI14149738, Length=610, Percent_Identity=27.8688524590164, Blast_Score=217, Evalue=4e-56,
Organism=Homo sapiens, GI156105687, Length=669, Percent_Identity=26.1584454409567, Blast_Score=172, Evalue=1e-42,
Organism=Escherichia coli, GI1787819, Length=688, Percent_Identity=40.1162790697674, Blast_Score=487, Evalue=1e-138,
Organism=Escherichia coli, GI1789913, Length=676, Percent_Identity=35.9467455621302, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI32565901, Length=651, Percent_Identity=21.3517665130568, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71999758, Length=591, Percent_Identity=22.165820642978, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319793, Length=570, Percent_Identity=27.5438596491228, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6322715, Length=673, Percent_Identity=21.5453194650817, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21356111, Length=585, Percent_Identity=24.4444444444444, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI20129717, Length=543, Percent_Identity=24.1252302025783, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 76113; Mature: 76113

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIASLNPALVNWTGHEGLPRFEAVRDEDFGPAFDAALAAHEAEIDAIARNAEPPSFGN
CCCCCCCCCCEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVVALEIAGDELSRVSALFWSKAGAHTNETIQALEREIAPKMSRHYSKIGTNPALFSRID
EEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALWERREDLGLDVEAMRVLERHWKSFVKSGAKLDKADQDRLAAINEKLASLGARFGQNVL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
ADEKAWALLLSSEEELAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSEIRE
CCCHHHEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
LREQAFRAWAARGENGGETDNRGIIGETLSLRAEKAELLGYENYAALKLDNTMAKTPDAV
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCHHH
NGLLMQVWEKAVARAREEEADLARLIAEEGRNHEVMPWDWRHYAEKLRAQRFSFSESELK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
PYLQLEKIIDACFAIGKRLFGLTAVEKKGIPAYHPDVRVYEIRDASGKLTALFLGDYFAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHCC
PSKRSGAWMSSFQSQHRLALKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
CCCCCCHHHHHHHHHHHEEECCCCCCCCEEEEEHHCCCCCCCCCCCEEECHHHHHHHHHH
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPEVLRTYAVHYRTGEPMPQAL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHH
LDKVLAARTFNSGFATVEFTASALVDMAYHTTEGVGDPMALEKATLDKIGLPKSIVMRHR
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCC
SPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDPFDPATAARLKDNIYSVGGSV
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
DPEDAYKAFRGKLPSPEAMLGKRGLAA
CHHHHHHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MNDIASLNPALVNWTGHEGLPRFEAVRDEDFGPAFDAALAAHEAEIDAIARNAEPPSFGN
CCCCCCCCCCEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVVALEIAGDELSRVSALFWSKAGAHTNETIQALEREIAPKMSRHYSKIGTNPALFSRID
EEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALWERREDLGLDVEAMRVLERHWKSFVKSGAKLDKADQDRLAAINEKLASLGARFGQNVL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
ADEKAWALLLSSEEELAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSEIRE
CCCHHHEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
LREQAFRAWAARGENGGETDNRGIIGETLSLRAEKAELLGYENYAALKLDNTMAKTPDAV
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCHHH
NGLLMQVWEKAVARAREEEADLARLIAEEGRNHEVMPWDWRHYAEKLRAQRFSFSESELK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
PYLQLEKIIDACFAIGKRLFGLTAVEKKGIPAYHPDVRVYEIRDASGKLTALFLGDYFAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHCC
PSKRSGAWMSSFQSQHRLALKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
CCCCCCHHHHHHHHHHHEEECCCCCCCCEEEEEHHCCCCCCCCCCCEEECHHHHHHHHHH
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPEVLRTYAVHYRTGEPMPQAL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHH
LDKVLAARTFNSGFATVEFTASALVDMAYHTTEGVGDPMALEKATLDKIGLPKSIVMRHR
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCC
SPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDPFDPATAARLKDNIYSVGGSV
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
DPEDAYKAFRGKLPSPEAMLGKRGLAA
CHHHHHHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]