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The map label for this gene is betA [C]

Identifier: 150398356

GI number: 150398356

Start: 3324751

End: 3326406

Strand: Reverse

Name: betA [C]

Synonym: Smed_3164

Alternate gene names: 150398356

Gene position: 3326406-3324751 (Counterclockwise)

Preceding gene: 150398357

Following gene: 150398355

Centisome position: 87.96

GC content: 63.89

Gene sequence:

>1656_bases
ATGAGCTATGACTATATCATTACCGGCGGAGGTCCTGCGGGCTGCGTTCTCGCAAACCGCCTGAGCGAGGACCCGGCCGT
CAAGGTGCTGCTTCTCGAGGCAGGCGGTGGCGATTGGAACCCGCTTTTCCACATGCCGGCCGGTTTCGCCAAGATGACGA
AGGGAGTCGCAAGCTGGGGCTGGCACACAGTGCCGCAGAAGCACATGAAGGGCAGGGTGCTGCGCTATACGCAGGCCAAG
GTGATCGGCGGCGGTTCCTCGATCAATGCGCAGCTTTATACGCGCGGCAACGCGGCGGATTACGACCTCTGGGCTGGCGA
GGATGGCTGCACCGGCTGGGATTATCGCAGCGTGCTGCCCTATTTCAAGCGCGCGGAAGACAACCAGCGTTTCGCCGACG
ATTATCACGCCTATGGCGGGCCGCTCGGCGTCTCCATGCCGGTTTCGACGCTGCCGATCTGCGACGCCTATATCCGCGCG
GGGCAGGAGCTCGGCATTCCCTACAATCACGATTTCAACGGCAAGCAGCAGGCGGGTGTCGGCTTTTATCAACTGACCCA
GCGTGATCGCCGCCGTTCCTCCGCTTCGCTGGCCTACCTTTCTCCGGTCAGGGACCGGAAAAACCTCATTGTGCGCACCG
GCGCTCGCGTAGCCCGCATCGTCCTCGAAGGAAAACGCGCGGTCGGTGTAGAGGTGGTAACGGGGAAAGGCAGCGAAATC
ATCCGTGCGAACCGGGAAGTGCTGGTCACCTCCGGCGCGATCGGCTCGCCCAAGCTGCTCCTTCAGTCCGGCATCGGCCC
GGCCGATCATCTGCGCTCCGTCGGCGTCGAGGTGCGGCACGATCTCCCCGGCGTTGGCGGGAACCTCCAGGATCACCTCG
ATCTCTTCGTCATTGCCGAATGCACCGGCGATCACACCTATGACGGCGTCGCCCGGCTGCACCGCACTTTCTGGGCCGGC
CTGCAATATGTGCTCTTCCGCTCCGGCCCGGTGGCCTCGTCGCTCTTCGAGACCGGCGGCTTCTGGTATGCCGATCCGAA
TGCCCGCTCGCCGGACATCCAGTTTCATCTCGGTCTCGGTTCGGGCATCGAGGCCGGCGTCGCCCGGCTCAAGAACGCCG
GCGTCACGCTCAACTCCGCCTATCTGCATCCGCGTTCGCGCGGCACCGTGCGGCTCTCCTCCGCCGATCCGGCGGCCGCA
CCGCTGATCGACCCGAACTATTGGGAGGACCCGCACGATCGCAAAATGTCGCTGGAAGGCCTGAAAATCGCGCGCGAGAT
CATGCAGCAGGCGGCATTGAAGCCCTTTGTCTTGGCTGAACGCTTGCCGGGAGACGAAATCCGGACCGAGGAACAGCTCT
TCGACTATGGCTGTGCCAATGCCAAGACCGACCACCACCCTGTCGGGACCTGCAGGATGGGCACCGATGCTTCGGCGGTC
GTCGATCTGGAGCTCAAAGTTCGCGGCATCGACGGACTGCGTGTCTGCGACAGTTCGGTCATGCCGCGGGTACCTTCCTG
CAATACCAATGGCCCGACGATTATGATGGGCGAGAAGGGGGCCGACATTATCCGCAGCCTGCCGCCGCTGCCGCCTGCCG
TCTTCCAGCACGAGCGCAACGATATGCGGCCGCGGGCGCGGACGGAGGTTCGGTGA

Upstream 100 bases:

>100_bases
CTTCTCCCCGGTCGCGGGTAGAGGGGACGTGGCTGACGCGCGGGAAAGGGCGGCAGCCGGTTGGGGGCGACACGCGGCAC
TTGACTTGAGGACGATGCGA

Downstream 100 bases:

>100_bases
GGGGCAATCTGGCACCGCAACAGTCTGACGCCTCGAAAGATCATTGCGACGGAAGCGTTCAGCCTGCATGGTGGCGCTTC
GTCTCCCCAACACGAAATCC

Product: choline dehydrogenase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSYDYIITGGGPAGCVLANRLSEDPAVKVLLLEAGGGDWNPLFHMPAGFAKMTKGVASWGWHTVPQKHMKGRVLRYTQAK
VIGGGSSINAQLYTRGNAADYDLWAGEDGCTGWDYRSVLPYFKRAEDNQRFADDYHAYGGPLGVSMPVSTLPICDAYIRA
GQELGIPYNHDFNGKQQAGVGFYQLTQRDRRRSSASLAYLSPVRDRKNLIVRTGARVARIVLEGKRAVGVEVVTGKGSEI
IRANREVLVTSGAIGSPKLLLQSGIGPADHLRSVGVEVRHDLPGVGGNLQDHLDLFVIAECTGDHTYDGVARLHRTFWAG
LQYVLFRSGPVASSLFETGGFWYADPNARSPDIQFHLGLGSGIEAGVARLKNAGVTLNSAYLHPRSRGTVRLSSADPAAA
PLIDPNYWEDPHDRKMSLEGLKIAREIMQQAALKPFVLAERLPGDEIRTEEQLFDYGCANAKTDHHPVGTCRMGTDASAV
VDLELKVRGIDGLRVCDSSVMPRVPSCNTNGPTIMMGEKGADIIRSLPPLPPAVFQHERNDMRPRARTEVR

Sequences:

>Translated_551_residues
MSYDYIITGGGPAGCVLANRLSEDPAVKVLLLEAGGGDWNPLFHMPAGFAKMTKGVASWGWHTVPQKHMKGRVLRYTQAK
VIGGGSSINAQLYTRGNAADYDLWAGEDGCTGWDYRSVLPYFKRAEDNQRFADDYHAYGGPLGVSMPVSTLPICDAYIRA
GQELGIPYNHDFNGKQQAGVGFYQLTQRDRRRSSASLAYLSPVRDRKNLIVRTGARVARIVLEGKRAVGVEVVTGKGSEI
IRANREVLVTSGAIGSPKLLLQSGIGPADHLRSVGVEVRHDLPGVGGNLQDHLDLFVIAECTGDHTYDGVARLHRTFWAG
LQYVLFRSGPVASSLFETGGFWYADPNARSPDIQFHLGLGSGIEAGVARLKNAGVTLNSAYLHPRSRGTVRLSSADPAAA
PLIDPNYWEDPHDRKMSLEGLKIAREIMQQAALKPFVLAERLPGDEIRTEEQLFDYGCANAKTDHHPVGTCRMGTDASAV
VDLELKVRGIDGLRVCDSSVMPRVPSCNTNGPTIMMGEKGADIIRSLPPLPPAVFQHERNDMRPRARTEVR
>Mature_550_residues
SYDYIITGGGPAGCVLANRLSEDPAVKVLLLEAGGGDWNPLFHMPAGFAKMTKGVASWGWHTVPQKHMKGRVLRYTQAKV
IGGGSSINAQLYTRGNAADYDLWAGEDGCTGWDYRSVLPYFKRAEDNQRFADDYHAYGGPLGVSMPVSTLPICDAYIRAG
QELGIPYNHDFNGKQQAGVGFYQLTQRDRRRSSASLAYLSPVRDRKNLIVRTGARVARIVLEGKRAVGVEVVTGKGSEII
RANREVLVTSGAIGSPKLLLQSGIGPADHLRSVGVEVRHDLPGVGGNLQDHLDLFVIAECTGDHTYDGVARLHRTFWAGL
QYVLFRSGPVASSLFETGGFWYADPNARSPDIQFHLGLGSGIEAGVARLKNAGVTLNSAYLHPRSRGTVRLSSADPAAAP
LIDPNYWEDPHDRKMSLEGLKIAREIMQQAALKPFVLAERLPGDEIRTEEQLFDYGCANAKTDHHPVGTCRMGTDASAVV
DLELKVRGIDGLRVCDSSVMPRVPSCNTNGPTIMMGEKGADIIRSLPPLPPAVFQHERNDMRPRARTEVR

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=540, Percent_Identity=40.5555555555556, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1786503, Length=538, Percent_Identity=40.3345724907063, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=37.3214285714286, Blast_Score=357, Evalue=7e-99,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=38.0622837370242, Blast_Score=336, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24642042, Length=563, Percent_Identity=37.8330373001776, Blast_Score=309, Evalue=4e-84,
Organism=Drosophila melanogaster, GI24642048, Length=568, Percent_Identity=36.6197183098592, Blast_Score=308, Evalue=7e-84,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=37.2759856630824, Blast_Score=302, Evalue=5e-82,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=37.0826010544815, Blast_Score=301, Evalue=8e-82,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=37.0826010544815, Blast_Score=301, Evalue=8e-82,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=37.3684210526316, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=36.0627177700348, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24650267, Length=575, Percent_Identity=34.6086956521739, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24642039, Length=567, Percent_Identity=35.2733686067019, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=34.9040139616056, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=34.0314136125654, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24642051, Length=566, Percent_Identity=33.7455830388693, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI18859993, Length=565, Percent_Identity=34.6902654867257, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24642057, Length=582, Percent_Identity=31.4432989690722, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24645930, Length=572, Percent_Identity=27.0979020979021, Blast_Score=145, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 60024; Mature: 59893

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDYIITGGGPAGCVLANRLSEDPAVKVLLLEAGGGDWNPLFHMPAGFAKMTKGVASWG
CCCEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCC
WHTVPQKHMKGRVLRYTQAKVIGGGSSINAQLYTRGNAADYDLWAGEDGCTGWDYRSVLP
CCCCCHHHHCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHH
YFKRAEDNQRFADDYHAYGGPLGVSMPVSTLPICDAYIRAGQELGIPYNHDFNGKQQAGV
HHHCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCC
GFYQLTQRDRRRSSASLAYLSPVRDRKNLIVRTGARVARIVLEGKRAVGVEVVTGKGSEI
CHHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCHHEEEEEEECCCEEEEEEEECCCCCE
IRANREVLVTSGAIGSPKLLLQSGIGPADHLRSVGVEVRHDLPGVGGNLQDHLDLFVIAE
EECCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCEECCCCCCCCCHHHCCEEEEEEE
CTGDHTYDGVARLHRTFWAGLQYVLFRSGPVASSLFETGGFWYADPNARSPDIQFHLGLG
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCEEEECCCCCCCCEEEEEECC
SGIEAGVARLKNAGVTLNSAYLHPRSRGTVRLSSADPAAAPLIDPNYWEDPHDRKMSLEG
CCHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LKIAREIMQQAALKPFVLAERLPGDEIRTEEQLFDYGCANAKTDHHPVGTCRMGTDASAV
HHHHHHHHHHHCCCCCHHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCEEECCCCCCEE
VDLELKVRGIDGLRVCDSSVMPRVPSCNTNGPTIMMGEKGADIIRSLPPLPPAVFQHERN
EEEEEEEECCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCHHHHHCCCC
DMRPRARTEVR
CCCCCHHCCCC
>Mature Secondary Structure 
SYDYIITGGGPAGCVLANRLSEDPAVKVLLLEAGGGDWNPLFHMPAGFAKMTKGVASWG
CCEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCC
WHTVPQKHMKGRVLRYTQAKVIGGGSSINAQLYTRGNAADYDLWAGEDGCTGWDYRSVLP
CCCCCHHHHCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHH
YFKRAEDNQRFADDYHAYGGPLGVSMPVSTLPICDAYIRAGQELGIPYNHDFNGKQQAGV
HHHCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCC
GFYQLTQRDRRRSSASLAYLSPVRDRKNLIVRTGARVARIVLEGKRAVGVEVVTGKGSEI
CHHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCHHEEEEEEECCCEEEEEEEECCCCCE
IRANREVLVTSGAIGSPKLLLQSGIGPADHLRSVGVEVRHDLPGVGGNLQDHLDLFVIAE
EECCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCEECCCCCCCCCHHHCCEEEEEEE
CTGDHTYDGVARLHRTFWAGLQYVLFRSGPVASSLFETGGFWYADPNARSPDIQFHLGLG
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCEEEECCCCCCCCEEEEEECC
SGIEAGVARLKNAGVTLNSAYLHPRSRGTVRLSSADPAAAPLIDPNYWEDPHDRKMSLEG
CCHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LKIAREIMQQAALKPFVLAERLPGDEIRTEEQLFDYGCANAKTDHHPVGTCRMGTDASAV
HHHHHHHHHHHCCCCCHHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCEEECCCCCCEE
VDLELKVRGIDGLRVCDSSVMPRVPSCNTNGPTIMMGEKGADIIRSLPPLPPAVFQHERN
EEEEEEEECCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCHHHHHCCCC
DMRPRARTEVR
CCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]