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The map label for this gene is dxs [C]

Identifier: 150398323

GI number: 150398323

Start: 3278009

End: 3278977

Strand: Direct

Name: dxs [C]

Synonym: Smed_3129

Alternate gene names: 150398323

Gene position: 3278009-3278977 (Clockwise)

Preceding gene: 150398322

Following gene: 150398324

Centisome position: 86.68

GC content: 65.63

Gene sequence:

>969_bases
ATGAACGCCGTGACATCGTCTGCCAAGTTGCACGATTGCCGTGACGCCTTCGTTACGGTGCTGGAGCGCCTCAGTGCGGA
TAACCCCAGGATCGTGGCCGTCTGCAACGACTCCGTCGGCTCCTCCAAGCTCGGCGGCTTCAGAGCCAGGTGGCCGGACC
GACTGGTCAATGTCGGCATCGCCGAACAGAACATGGTCGGTGTCGGCGCTGGCCTTGCCAATGGCGGACTGCTGCCCTTC
GTCTGCGGCGCCGCCTGTTTCCTCACGGGCCGGTCGCTGGAGCAGATCAAGGCCGACATCGCTTATTCCAACGCAAACGT
GAAGCTCATCGGCATTTCCTCCGGGATGGCCTATGGCGAGCTCGGGCCGACGCACCACTCCATCGAGGATTTCGCCTGGA
CCCGCGTGTTGCCGAACCTTCCGGTCATCGCACCCTGCGACTCGGTCGAAACCGCCGCGGCCGTCGAATGGGCCGCCCAT
TATGATGGCCCGGTTTTTCTGCGCCTGTCGCGCGTCGGCGTTCCGGACCTGCTGCCGTCCGGCCACACATTCGAACTGGG
CAAGGCCAACCTGTTGCGGGACGGCGACGCGATCACCCTCGTCGCCAACGGCACGGTGACCCACCGCATCCTGAAGGCTG
CCGATCTGCTGGCGGCAGAGGGCATAGAGGCACGCGTGCTGAATATGGCGACAGTCCGGCCGCTCGATCTCGATGCCGTC
GTGGCCGCCGCGCGCGAGACCGGAGCCATCCTGACGGCGGAAGAGCATTCCACCTTCGGCGGGCTCGGTTCGGCCGTGGC
CGAACTTGTCGTGGCCGAAGCGCCCGTGCCGATGAAGATCCTCGGCGTTCCGGGAATTTTCGCCCCGACCGGGTCGGCCG
AATTCCTGCTCGACGAATTCGGCATGTCCCCTGCCGCCATCGCCGAAGCGGCCGTCGCACTGATCGCACGAAAGCCCTCC
CGCGCATGA

Upstream 100 bases:

>100_bases
ACGGCATATCCTTCATGCAGGACAAGGTCGACTGGCACCACAAGGTGCCGAACGACGAACAATACAAGATTGCCGTGGCT
GAGCTTTCGGAGGCCCTGTG

Downstream 100 bases:

>100_bases
TCATGCGCAGGTAGATTTCGTGCCGGGCGCGGCAATCCTCCTGCCGCGCCCCATTCCTGTCAGCCGGAGCCGCCATGACG
ACTGCCATTCTCGCCATCGA

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLGGFRARWPDRLVNVGIAEQNMVGVGAGLANGGLLPF
VCGAACFLTGRSLEQIKADIAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAH
YDGPVFLRLSRVGVPDLLPSGHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGIEARVLNMATVRPLDLDAV
VAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKILGVPGIFAPTGSAEFLLDEFGMSPAAIAEAAVALIARKPS
RA

Sequences:

>Translated_322_residues
MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLGGFRARWPDRLVNVGIAEQNMVGVGAGLANGGLLPF
VCGAACFLTGRSLEQIKADIAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAH
YDGPVFLRLSRVGVPDLLPSGHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGIEARVLNMATVRPLDLDAV
VAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKILGVPGIFAPTGSAEFLLDEFGMSPAAIAEAAVALIARKPS
RA
>Mature_322_residues
MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLGGFRARWPDRLVNVGIAEQNMVGVGAGLANGGLLPF
VCGAACFLTGRSLEQIKADIAYSNANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAH
YDGPVFLRLSRVGVPDLLPSGHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGIEARVLNMATVRPLDLDAV
VAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKILGVPGIFAPTGSAEFLLDEFGMSPAAIAEAAVALIARKPS
RA

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=308, Percent_Identity=36.6883116883117, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI4507521, Length=308, Percent_Identity=36.6883116883117, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI133778974, Length=301, Percent_Identity=34.8837209302326, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI225637463, Length=306, Percent_Identity=32.3529411764706, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI225637461, Length=306, Percent_Identity=32.3529411764706, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI225637459, Length=306, Percent_Identity=32.3529411764706, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI156564403, Length=241, Percent_Identity=26.5560165975104, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI291084858, Length=229, Percent_Identity=26.6375545851528, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786622, Length=316, Percent_Identity=31.0126582278481, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI48994911, Length=270, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788808, Length=192, Percent_Identity=29.6875, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=302, Percent_Identity=33.112582781457, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17538422, Length=292, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=304, Percent_Identity=25.9868421052632, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551847, Length=301, Percent_Identity=32.890365448505, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI45550715, Length=301, Percent_Identity=32.890365448505, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24645119, Length=301, Percent_Identity=32.890365448505, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24666278, Length=308, Percent_Identity=32.1428571428571, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21358145, Length=290, Percent_Identity=26.2068965517241, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650940, Length=290, Percent_Identity=26.2068965517241, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33423; Mature: 33423

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLGGFRARWPDRLVNVGI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC
AEQNMVGVGAGLANGGLLPFVCGAACFLTGRSLEQIKADIAYSNANVKLIGISSGMAYGE
CCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCCEEEEEECCCCCCCC
LGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAHYDGPVFLRLSRVGVPDLLPS
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
GHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGIEARVLNMATVRPLDLDAV
CCEEECCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEHEECCCCCHHHH
VAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKILGVPGIFAPTGSAEFLLDEF
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEECCCCCHHHHHHHH
GMSPAAIAEAAVALIARKPSRA
CCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLGGFRARWPDRLVNVGI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC
AEQNMVGVGAGLANGGLLPFVCGAACFLTGRSLEQIKADIAYSNANVKLIGISSGMAYGE
CCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCCEEEEEECCCCCCCC
LGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAHYDGPVFLRLSRVGVPDLLPS
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
GHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGIEARVLNMATVRPLDLDAV
CCEEECCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEHEECCCCCHHHH
VAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKILGVPGIFAPTGSAEFLLDEF
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEECCCCCHHHHHHHH
GMSPAAIAEAAVALIARKPSRA
CCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]