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The map label for this gene is hisC2 [H]

Identifier: 150398317

GI number: 150398317

Start: 3271524

End: 3272579

Strand: Direct

Name: hisC2 [H]

Synonym: Smed_3123

Alternate gene names: 150398317

Gene position: 3271524-3272579 (Clockwise)

Preceding gene: 150398316

Following gene: 150398322

Centisome position: 86.5

GC content: 62.12

Gene sequence:

>1056_bases
ATGAGCAGATTCTGGTCGCCGATCGTTGCCGCCTTGAAGCCTTACGTTCCCGGTGAACAGCCGCGGATGGCGAACCTCGT
CAAGCTCAACACCAATGAGAGCCCCTATGGCCCCTCGGAAAAAGCGCTGGAGGCGATTCGGGCGGCGGCTGACATGGATC
TCAGGCTTTATCCGGATCCCGTCGCTCTCGGGTTGCGGGAGGCGATCGCCAGGCGCTACGGCATGTCCGTCGGCGAGGTC
TTCGTCGGCAATGGTTCCGACGAGGTTCTGGCCCACACCTTCGCGGCGCTTTTGAAACACGATCGGCCGCTGCTTTATCC
TGACATCTCCTACAGCTTCTATCCGACCTATGCGGGCCTTTTCGGCATCGAAGCGGTCGAGATTCCGCTGAACGCCGACT
TCCGCATCGAAATTGCAGGCTATCGCCGCCCTGCCGGCGCCATCATCCTGCCGAATCCGAATGCGCCGACGGGAATCGGC
CTGCCGCTTTCCGACATTGAAAGGCTGGTGAGCGAGCATTCCGACCAGCCCGTGGTCGTCGACGAGGCCTATATCGACTT
CGGCGGCGAATCCGCGATCGCACTCGTTCCGAAATACGAGAACCTGCTCGTCGTTCAGACCTTCTCGAAGTCACGTGCGC
TTGCCGGTCTTCGCGTCGGCTTCGCGATAGGCCAAAGGCCGCTGATCGAGGCGTTGGAGCGCGTCAAGGATAGTTTCAAT
TCCTATCCGCTCGGGCGCGCCGCCCTTGCGGGTGCAACGGCTGCGATCGAGGACGAGGCCTGGTTCGAGAAGACGCGCGC
CAAGATCCTCGCCACGCGGGCGGCATTGACGAAGGGGCTCGAAGCGCGCGGTTTCGAGGTCCTGCCGTCTCAGGCGAATT
TCGTCTTCGCCCGGCATCAGAACCACGCGGGCCAGACGCTGGCGGCGAAACTCCGCGAACGCGCGGTCATCGTCCGCCGT
TTTGCCAAGCCCCGGATTGAGGATTTCCTGCGCATCACCATCGGCACCGATGATGAATGCGCCAAACTGGTCGCGGCGCT
CGACGAAATTCTGTGA

Upstream 100 bases:

>100_bases
CCTGGTGGCCGAGGCGGAAGCGCTCCTTGAGCCTTATGGCGCCCGTTCGGAGGTCCTTGCCGAGACCGCTCGTTTCATTG
CCAACCGCAGGAACTGATAG

Downstream 100 bases:

>100_bases
GATCGCAGGTCAGATTGAAGCGGCACCGGCGAGATTGCGGCGCCGCCTCCTGACCGGCGATATCACCAGCAGCAGAAGCC
GCCATCAACGAGAAGGTCTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDPVALGLREAIARRYGMSVGEV
FVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGLFGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIG
LPLSDIERLVSEHSDQPVVVDEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFN
SYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQNHAGQTLAAKLRERAVIVRR
FAKPRIEDFLRITIGTDDECAKLVAALDEIL

Sequences:

>Translated_351_residues
MSRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDPVALGLREAIARRYGMSVGEV
FVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGLFGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIG
LPLSDIERLVSEHSDQPVVVDEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFN
SYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQNHAGQTLAAKLRERAVIVRR
FAKPRIEDFLRITIGTDDECAKLVAALDEIL
>Mature_350_residues
SRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDPVALGLREAIARRYGMSVGEVF
VGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGLFGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIGL
PLSDIERLVSEHSDQPVVVDEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFNS
YPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQNHAGQTLAAKLRERAVIVRRF
AKPRIEDFLRITIGTDDECAKLVAALDEIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=350, Percent_Identity=27.1428571428571, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788722, Length=257, Percent_Identity=32.6848249027237, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=387, Percent_Identity=28.4237726098191, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38400; Mature: 38268

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDP
CCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCH
VALGLREAIARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGL
HHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
FGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPLSDIERLVSEHSDQPVVV
HCCEEEEECCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
DEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFN
EEHEECCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
SYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQ
CCCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECC
NHAGQTLAAKLRERAVIVRRFAKPRIEDFLRITIGTDDECAKLVAALDEIL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHHC
>Mature Secondary Structure 
SRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDP
CCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCH
VALGLREAIARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGL
HHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
FGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPLSDIERLVSEHSDQPVVV
HCCEEEEECCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
DEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFN
EEHEECCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
SYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQ
CCCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECC
NHAGQTLAAKLRERAVIVRRFAKPRIEDFLRITIGTDDECAKLVAALDEIL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]