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The map label for this gene is ydhC [H]

Identifier: 150398256

GI number: 150398256

Start: 3210288

End: 3211526

Strand: Direct

Name: ydhC [H]

Synonym: Smed_3062

Alternate gene names: 150398256

Gene position: 3210288-3211526 (Clockwise)

Preceding gene: 150398255

Following gene: 150398258

Centisome position: 84.89

GC content: 64.16

Gene sequence:

>1239_bases
ATGACGCTCCGGATGAGCGAACGGCGCACGAGCATCATCGGCGCCTTTCTGGTGGCACTCGGCCCTATATCGATGGCGCT
CTACACGCCGGCAATGCCGGAGCTCGTGCGTGCCTTCGCCTCCAGCGAAGCGGCAATCAAGATGACGCTGTCGCTCTATT
TCGGCGGCTTCGCCTTCGCTCAACTCGTTTCGGGCACGCTTTCCGACGTTATCGGCCGGCGGCGTACAACGTTGATCTTC
ATGGCGATCTACCTCGCCGGGAGCCTGATGGCGGCCTTCGCGCCCTCGATCCCGGTGCTGCTCGCCGGCCGCCTGGTGCA
GGGGATCGGCGCCTCAGTCGGAATGACGGTATCGCGCGCGCTCGTTCGCGATCAGTTCACCGGGACGACTGCGGCCCGGA
TCATGAACATGATCGGCATGATGCTGGCGCTCGGGCCCGCGGTCTCACCGACCCTCGGCGGCATCGCGCTCGGCCTTTTC
GGCTGGCAGTCGATCTTCCTGCTGATGGTGGGCTTTGCCCTGACGGCCTGCTTGGTCGTGCAATTCTTCATGGTGGAAAC
CGCGACGCCGGACCGCAGCAAGGGGCACCTCGCACTCATATTCGCGGCCTATTGCCAGCTTATGAGCGACAGCCGTTTCA
TGTCTTCCACTCTGGTGATCGCCGGCGCCGTTGGTGCGCTCTATGCCTGGGCCACCATGCTCCCCTTCGTTCTGATCAGC
CAGGTCGGCCTCACGCCCACAGCGTTCGGCATCGGCATGCTCATGCAATCCGGCCTGTTTTTTTCGGGCACGGTCACGAT
GCGCCTCATGATGCGACGCTTCACCCCGCAGGCACTCGTGCCCGTCGGACTCTCATTCATCGGCGCGGCGAGCCTCGCCC
TCGCCTTCACCATGCATGCGCTGGAGCCGACCTTCCTTTCGGTGATGACGCCGATCGGGATCTATGCTTTCGGCATCGCC
TTTGTCATGCCCTACATGATGACGGCGGCGTTGGCCCCCTTTCCGCACATCGCCGGCACCGCTTCGGCCATGATGGGCTT
CATCCAGATGAGTGCCGGGCTTCTCGGCGGCGCACTTGCTGCCCTCGTCGGCGTGCCCGCCTTGGCGCTCGGCACGATCA
TCCCGAGCTTCGGCCTTGTCTCGCTAGCAAGCTATCTCTGGTATCGCAGGGCCGTTCGACTGAGGCCGCTGGCCGCGCCG
ACGGCCGAGCAAGATCCTATCGTTCAGGCGGCGGAATGA

Upstream 100 bases:

>100_bases
ACGAAGGACGCGAGGTCCTGCGTGCAAACCTGAGGATTCTCCGTGACAGTCTCCACCGCCTCGATCCATGCCTCGCCGGC
AAGGGGAAGGGGGAGGCCGA

Downstream 100 bases:

>100_bases
GCGGAGACGAGCCGCGGCGAATTGCTCCACCGCAGCTCCCGCTCAATCGTCTCAGCGATTGCGCGCCGCGAGCGTGCGCA
GGCGCAGCGCGTTGAGCTTG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTLRMSERRTSIIGAFLVALGPISMALYTPAMPELVRAFASSEAAIKMTLSLYFGGFAFAQLVSGTLSDVIGRRRTTLIF
MAIYLAGSLMAAFAPSIPVLLAGRLVQGIGASVGMTVSRALVRDQFTGTTAARIMNMIGMMLALGPAVSPTLGGIALGLF
GWQSIFLLMVGFALTACLVVQFFMVETATPDRSKGHLALIFAAYCQLMSDSRFMSSTLVIAGAVGALYAWATMLPFVLIS
QVGLTPTAFGIGMLMQSGLFFSGTVTMRLMMRRFTPQALVPVGLSFIGAASLALAFTMHALEPTFLSVMTPIGIYAFGIA
FVMPYMMTAALAPFPHIAGTASAMMGFIQMSAGLLGGALAALVGVPALALGTIIPSFGLVSLASYLWYRRAVRLRPLAAP
TAEQDPIVQAAE

Sequences:

>Translated_412_residues
MTLRMSERRTSIIGAFLVALGPISMALYTPAMPELVRAFASSEAAIKMTLSLYFGGFAFAQLVSGTLSDVIGRRRTTLIF
MAIYLAGSLMAAFAPSIPVLLAGRLVQGIGASVGMTVSRALVRDQFTGTTAARIMNMIGMMLALGPAVSPTLGGIALGLF
GWQSIFLLMVGFALTACLVVQFFMVETATPDRSKGHLALIFAAYCQLMSDSRFMSSTLVIAGAVGALYAWATMLPFVLIS
QVGLTPTAFGIGMLMQSGLFFSGTVTMRLMMRRFTPQALVPVGLSFIGAASLALAFTMHALEPTFLSVMTPIGIYAFGIA
FVMPYMMTAALAPFPHIAGTASAMMGFIQMSAGLLGGALAALVGVPALALGTIIPSFGLVSLASYLWYRRAVRLRPLAAP
TAEQDPIVQAAE
>Mature_411_residues
TLRMSERRTSIIGAFLVALGPISMALYTPAMPELVRAFASSEAAIKMTLSLYFGGFAFAQLVSGTLSDVIGRRRTTLIFM
AIYLAGSLMAAFAPSIPVLLAGRLVQGIGASVGMTVSRALVRDQFTGTTAARIMNMIGMMLALGPAVSPTLGGIALGLFG
WQSIFLLMVGFALTACLVVQFFMVETATPDRSKGHLALIFAAYCQLMSDSRFMSSTLVIAGAVGALYAWATMLPFVLISQ
VGLTPTAFGIGMLMQSGLFFSGTVTMRLMMRRFTPQALVPVGLSFIGAASLALAFTMHALEPTFLSVMTPIGIYAFGIAF
VMPYMMTAALAPFPHIAGTASAMMGFIQMSAGLLGGALAALVGVPALALGTIIPSFGLVSLASYLWYRRAVRLRPLAAPT
AEQDPIVQAAE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=346, Percent_Identity=29.1907514450867, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788509, Length=349, Percent_Identity=27.5071633237822, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790146, Length=357, Percent_Identity=24.6498599439776, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082312, Length=344, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787065, Length=333, Percent_Identity=24.3243243243243, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790195, Length=162, Percent_Identity=27.7777777777778, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43373; Mature: 43242

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
7.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
7.1 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLRMSERRTSIIGAFLVALGPISMALYTPAMPELVRAFASSEAAIKMTLSLYFGGFAFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QLVSGTLSDVIGRRRTTLIFMAIYLAGSLMAAFAPSIPVLLAGRLVQGIGASVGMTVSRA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
LVRDQFTGTTAARIMNMIGMMLALGPAVSPTLGGIALGLFGWQSIFLLMVGFALTACLVV
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFFMVETATPDRSKGHLALIFAAYCQLMSDSRFMSSTLVIAGAVGALYAWATMLPFVLIS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVGLTPTAFGIGMLMQSGLFFSGTVTMRLMMRRFTPQALVPVGLSFIGAASLALAFTMHA
HCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEPTFLSVMTPIGIYAFGIAFVMPYMMTAALAPFPHIAGTASAMMGFIQMSAGLLGGALA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALVGVPALALGTIIPSFGLVSLASYLWYRRAVRLRPLAAPTAEQDPIVQAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]