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The map label for this gene is obgE [H]

Identifier: 150398204

GI number: 150398204

Start: 3157393

End: 3158403

Strand: Direct

Name: obgE [H]

Synonym: Smed_3009

Alternate gene names: 150398204

Gene position: 3157393-3158403 (Clockwise)

Preceding gene: 150398203

Following gene: 150398205

Centisome position: 83.49

GC content: 64.39

Gene sequence:

>1011_bases
ATGAAATTCCTCGACGAAACGAAAGTCTATATCCGGTCCGGAGACGGCGGCGCGGGCGCCGTGTCCTTCCGCCGCGAGAA
GTTCATCGAGTTCGGTGGCCCGGATGGCGGCGACGGCGGCCGTGGCGGCGATGTCTGGGTGGAGGCCGTCAATGGCCTCA
ATACCCTCATCGACTTCCGGTATCAGCAGCATTTCAAGGCCAAGACCGGCACGCACGGCATGGGCCGCAACCGCACCGGC
GCCAAAGGCGCCGACGTGACCCTGAAAGTGCCGGTCGGCACGCAGATCTTCGAGGAGGACAGCGAAACGCTGATCGTCGA
CATGGTGGCGGAAGGGCAGCGCTACCGGCTTGCCGCCGGCGGCAATGGCGGCTTCGGAAACGCGCATTTCAAGTCCTCGA
CCAACCAGGCACCCAATTGGGCCAATCCCGGGCTCGAGGGCGAGGAGAAAACCATCTGGCTGCGGCTGAAGCTGATTGCC
GATGCCGGCCTCGTCGGTCTGCCCAATGCCGGCAAATCGACTTTTCTCGCCGCCTGCACCCGCGCCCGGCCGAAAATCGC
CAACTATCCTTTCACGACGCTGCACCCCAATCTCGGCGTCGCGACCGTCGACGAGAAGGAATTCATCATCGCCGACATTC
CCGGGCTGATCGAAGGGGCGCATGAGGGCGTGGGTATCGGCGACCGCTTTCTCGGCCATGTCGAGCGCACCCGCGTGCTG
CTGCACCTCGTCTCCGCGCAGGAGGAGGATGTCGCCAAGGCCTACAAGACGGTGAAGCACGAGCTCGAGGCCTATGGCGG
GGGGCTCGAGGAAAAGCCGCAGATCGTGGCTCTGTCGCAGATCGACGTGCTCGACGAAGCCGAGTTGAAGGCGAAGAGCA
AGGCGCTCGGCAAAGCCTGCGGCACGCCGCCGCTGCTTATCTCCGCCGTCACCAACAAGGGCATGACGGAAACACTGAGA
GCATTGCGCAGCGTCATCGACGCGGCCAAGGCGGGCGAGGAGGACGCCTGA

Upstream 100 bases:

>100_bases
GCCGGGCACGACCTGGGCGGGGTTTGTCATACGATAATCTTTGACCTCTGCGGGAACGGCCTATATCGATGGCGACCTAA
AGAAAACAGATGGCGATCCG

Downstream 100 bases:

>100_bases
GCATGACCAAGGCCCGCAAAGCGCTCGATAAATACCGCCGGGTCGTGATCAAGATAGGCTCGGCGCTGCTCGTCGACCGC
AAGACGGGTTTGAAGAAGAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKFLDETKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFRYQQHFKAKTGTHGMGRNRTG
AKGADVTLKVPVGTQIFEEDSETLIVDMVAEGQRYRLAAGGNGGFGNAHFKSSTNQAPNWANPGLEGEEKTIWLRLKLIA
DAGLVGLPNAGKSTFLAACTRARPKIANYPFTTLHPNLGVATVDEKEFIIADIPGLIEGAHEGVGIGDRFLGHVERTRVL
LHLVSAQEEDVAKAYKTVKHELEAYGGGLEEKPQIVALSQIDVLDEAELKAKSKALGKACGTPPLLISAVTNKGMTETLR
ALRSVIDAAKAGEEDA

Sequences:

>Translated_336_residues
MKFLDETKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFRYQQHFKAKTGTHGMGRNRTG
AKGADVTLKVPVGTQIFEEDSETLIVDMVAEGQRYRLAAGGNGGFGNAHFKSSTNQAPNWANPGLEGEEKTIWLRLKLIA
DAGLVGLPNAGKSTFLAACTRARPKIANYPFTTLHPNLGVATVDEKEFIIADIPGLIEGAHEGVGIGDRFLGHVERTRVL
LHLVSAQEEDVAKAYKTVKHELEAYGGGLEEKPQIVALSQIDVLDEAELKAKSKALGKACGTPPLLISAVTNKGMTETLR
ALRSVIDAAKAGEEDA
>Mature_336_residues
MKFLDETKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFRYQQHFKAKTGTHGMGRNRTG
AKGADVTLKVPVGTQIFEEDSETLIVDMVAEGQRYRLAAGGNGGFGNAHFKSSTNQAPNWANPGLEGEEKTIWLRLKLIA
DAGLVGLPNAGKSTFLAACTRARPKIANYPFTTLHPNLGVATVDEKEFIIADIPGLIEGAHEGVGIGDRFLGHVERTRVL
LHLVSAQEEDVAKAYKTVKHELEAYGGGLEEKPQIVALSQIDVLDEAELKAKSKALGKACGTPPLLISAVTNKGMTETLR
ALRSVIDAAKAGEEDA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=335, Percent_Identity=38.2089552238806, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI111955139, Length=367, Percent_Identity=34.8773841961853, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI111955063, Length=253, Percent_Identity=32.0158102766798, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI58761500, Length=105, Percent_Identity=36.1904761904762, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789574, Length=332, Percent_Identity=48.4939759036145, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI1787454, Length=108, Percent_Identity=37.037037037037, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=326, Percent_Identity=36.8098159509202, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=322, Percent_Identity=30.4347826086957, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17509631, Length=106, Percent_Identity=35.8490566037736, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71981008, Length=121, Percent_Identity=33.8842975206612, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=113, Percent_Identity=45.1327433628319, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI20129375, Length=339, Percent_Identity=35.9882005899705, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585318, Length=307, Percent_Identity=34.8534201954397, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640873, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640877, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640875, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35838; Mature: 35838

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDETKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YQQHFKAKTGTHGMGRNRTGAKGADVTLKVPVGTQIFEEDSETLIVDMVAEGQRYRLAAG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCEEEEEEECCCCEEEEEEC
GNGGFGNAHFKSSTNQAPNWANPGLEGEEKTIWLRLKLIADAGLVGLPNAGKSTFLAACT
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCHHHHHHHH
RARPKIANYPFTTLHPNLGVATVDEKEFIIADIPGLIEGAHEGVGIGDRFLGHVERTRVL
HCCCCCCCCCCEEECCCCCEEEECCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHH
LHLVSAQEEDVAKAYKTVKHELEAYGGGLEEKPQIVALSQIDVLDEAELKAKSKALGKAC
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHC
GTPPLLISAVTNKGMTETLRALRSVIDAAKAGEEDA
CCCCEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKFLDETKVYIRSGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWVEAVNGLNTLIDFR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YQQHFKAKTGTHGMGRNRTGAKGADVTLKVPVGTQIFEEDSETLIVDMVAEGQRYRLAAG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCEEEEEEECCCCEEEEEEC
GNGGFGNAHFKSSTNQAPNWANPGLEGEEKTIWLRLKLIADAGLVGLPNAGKSTFLAACT
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCHHHHHHHH
RARPKIANYPFTTLHPNLGVATVDEKEFIIADIPGLIEGAHEGVGIGDRFLGHVERTRVL
HCCCCCCCCCCEEECCCCCEEEECCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHH
LHLVSAQEEDVAKAYKTVKHELEAYGGGLEEKPQIVALSQIDVLDEAELKAKSKALGKAC
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHC
GTPPLLISAVTNKGMTETLRALRSVIDAAKAGEEDA
CCCCEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]