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The map label for this gene is sdhA [H]

Identifier: 150398154

GI number: 150398154

Start: 3105203

End: 3107044

Strand: Reverse

Name: sdhA [H]

Synonym: Smed_2957

Alternate gene names: 150398154

Gene position: 3107044-3105203 (Counterclockwise)

Preceding gene: 150398155

Following gene: 150398153

Centisome position: 82.16

GC content: 64.17

Gene sequence:

>1842_bases
ATGGCATCGATCAGCACGCCCGCTGCAAACGGCAAGGCATACAAGTATGTCGACCACTCCTTCGACGTTGTCGTCGTGGG
CGCCGGCGGGGCGGGCCTGCGCGCGACGCTCGGCATGGCCGAGCAGGGCCTGAGGACGGCCTGCATCACCAAGGTCTTCC
CGACGCGCTCGCATACGGTCGCGGCACAAGGCGGCATCGCCGCTTCGCTGCAGAACATGACGCCCGACTGCTGGCAATGG
CACCTTTACGACACCGTCAAGGGCTCGGACTGGCTCGGCGACGTCGACGCCATGCAGTATCTCGCCATGGAGGCGCCGAA
GGCGGTCTACGAGCTCGAGCACTATGGCGTTCCCTTCTCGCGCAACGAGGAAGGCAAGATCTACCAGCGCCCCTTTGGCG
GCCACATGCAGAATTACGGCGAAGGACCGCCGGTACAGCGCACCTGTGCGGCCGCCGACCGCACCGGCCACGCGATCCTG
CATACGCTTTACGGCCAGTCGCTCAGGAACAATGCCGAATTCTTCATCGAGTATTTCGCCATCGACCTGATCATGTCGGA
TGACGGACGATGCACCGGCGTCGTCGCCTGGAATCTCGACGATGGCACGATCCACCGGTTCGCGGCAAAGATGGTGGTAC
TGGCGACCGGCGGCTACGGCCGCGCCTATTTTTCGGCGACTTCGGCGCATACGTGTACGGGCGACGGTGGGGGCATGATC
GCGCGTGCCGGCCTGCCGCTGCAGGACATGGAATTCGTGCAATTCCATCCGACCGGCATCTACGGTGCGGGTTGCCTCAT
CACCGAAGGCGCACGCGGCGAGGGCGGGTATCTCGTCAATTCCGAGGGCGAGCGTTTTATGGAGCGCTATGCGCCCTCGG
CCAAGGACCTTGCCTCGCGCGACGTCGTTTCCCGCTGCATGACGATGGAAATCCGCGAGGGACGAGGCGTCGGGAAGAAC
AAGGACCACATCTTCCTGCACCTCGACCATCTCGATCCGGCGGTACTGCATGAGCGTCTGCCCGGAATTTCGGAGTCGGC
GAAGATCTTTGCGGGCGTCGACGTCACGCGCGAACCGATTCCGGTGCTGCCGACTGTTCATTACAACATGGGCGGCGTGC
CGACCAATTACTGGGGCGAAGTGCTGAACGCGGACAGCCAGAACCCCGAGCGCATCGCGCCCGGGCTGATGGCCGTCGGC
GAAGCCGGCTGCGCTTCGGTGCACGGCGCCAATCGGCTCGGCTCGAACTCGCTGATCGACCTTGTCGTCTTCGGCCGTGC
GGCGGCTATCCGCGCCGGCCAGATCATCGACCGCAACGCGGCGGTACCGGAGGTCGATATTGCTGCATGCGACCGCATCA
TGGACCGTTTCGACCGGCTGCGGCACGCGAATGGCGCAACGCCGACGGCCGTTCTGCGCGACAAGATGCAGCGCGCCATG
CAGGAAGATGCGGCCGTGTTCCGCACGCAGGAATCGCTCGAATCCGGCTGTCGGCGCCTGTCGGCGATCTGGAAGGAACT
GCCGGATATCAGGGTTACCGACCGTTCGATGATCTGGAATTCGGATCTCGTCGAGACGCTGGAGCTCGAAAACCTGATGG
CCAATGCCATCACCACGGTCTACGGCGCCGAAGCGCGCAAGGAAAGCCGCGGCGCACATGCGCGCGAGGACTATAAGGAC
GGCCCGCTCGGCGGCCGCGATGACGTCAACTGGCGCAAGCATACGCTTGCCTGGGTCAACGACGCGGGCGACGTCCGGCT
CGATTTTCGTCCGGTTCACACCGAGCTGATCGCCGAAGGCATCGATCCTTACAAGATCGAGCCCAAGGCCCGCGTCTACT
GA

Upstream 100 bases:

>100_bases
AAGATCGCACTTCTCATGCTCAACACATTCTTCACGATCGCGGTCGGCGGACTCTGTCTTTTCGCCGTCCTGAAGATCGC
TTTTGCAGGATAATTTCGCC

Downstream 100 bases:

>100_bases
TCTCGAGGACTAAGGCACATGGTTGAACTCGCACTTCCCAAGAACTCGCAGATCACCGAAGGCAAGGTGTGGCCGAAACC
GGTCGGCGCGGCCAATCTCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MASISTPAANGKAYKYVDHSFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLQNMTPDCWQW
HLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAIL
HTLYGQSLRNNAEFFIEYFAIDLIMSDDGRCTGVVAWNLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKN
KDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGVPTNYWGEVLNADSQNPERIAPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQIIDRNAAVPEVDIAACDRIMDRFDRLRHANGATPTAVLRDKMQRAM
QEDAAVFRTQESLESGCRRLSAIWKELPDIRVTDRSMIWNSDLVETLELENLMANAITTVYGAEARKESRGAHAREDYKD
GPLGGRDDVNWRKHTLAWVNDAGDVRLDFRPVHTELIAEGIDPYKIEPKARVY

Sequences:

>Translated_613_residues
MASISTPAANGKAYKYVDHSFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLQNMTPDCWQW
HLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAIL
HTLYGQSLRNNAEFFIEYFAIDLIMSDDGRCTGVVAWNLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKN
KDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGVPTNYWGEVLNADSQNPERIAPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQIIDRNAAVPEVDIAACDRIMDRFDRLRHANGATPTAVLRDKMQRAM
QEDAAVFRTQESLESGCRRLSAIWKELPDIRVTDRSMIWNSDLVETLELENLMANAITTVYGAEARKESRGAHAREDYKD
GPLGGRDDVNWRKHTLAWVNDAGDVRLDFRPVHTELIAEGIDPYKIEPKARVY
>Mature_612_residues
ASISTPAANGKAYKYVDHSFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLQNMTPDCWQWH
LYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILH
TLYGQSLRNNAEFFIEYFAIDLIMSDDGRCTGVVAWNLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMIA
RAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIREGRGVGKNK
DHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGVPTNYWGEVLNADSQNPERIAPGLMAVGE
AGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQIIDRNAAVPEVDIAACDRIMDRFDRLRHANGATPTAVLRDKMQRAMQ
EDAAVFRTQESLESGCRRLSAIWKELPDIRVTDRSMIWNSDLVETLELENLMANAITTVYGAEARKESRGAHAREDYKDG
PLGGRDDVNWRKHTLAWVNDAGDVRLDFRPVHTELIAEGIDPYKIEPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=613, Percent_Identity=61.0114192495922, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=557, Percent_Identity=52.2441651705566, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1790597, Length=586, Percent_Identity=41.4675767918089, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=31.7939609236234, Blast_Score=215, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=632, Percent_Identity=59.8101265822785, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=617, Percent_Identity=58.5089141004862, Blast_Score=703, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=608, Percent_Identity=62.6644736842105, Blast_Score=763, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=612, Percent_Identity=62.2549019607843, Blast_Score=758, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=27.3100616016427, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=64.0728476821192, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=64.0728476821192, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=64.0728476821192, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=615, Percent_Identity=55.1219512195122, Blast_Score=691, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66991; Mature: 66860

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASISTPAANGKAYKYVDHSFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTV
CCCCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEE
AAQGGIAASLQNMTPDCWQWHLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFS
EECCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
RNEEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILHTLYGQSLRNNAEFFIEYFA
CCCCCCEEECCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
IDLIMSDDGRCTGVVAWNLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
EEEEECCCCCEEEEEEEECCCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTMEIREGRGVGKNKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPI
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGVPTNYWGEVLNADSQNPERIAPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAGQIIDRNAAVPEVDIAACDRIMDRFDRLRHANGATPTAVLRDKMQRAM
EEECCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QEDAAVFRTQESLESGCRRLSAIWKELPDIRVTDRSMIWNSDLVETLELENLMANAITTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHH
YGAEARKESRGAHAREDYKDGPLGGRDDVNWRKHTLAWVNDAGDVRLDFRPVHTELIAEG
HCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHCC
IDPYKIEPKARVY
CCCEEECCCCCCC
>Mature Secondary Structure 
ASISTPAANGKAYKYVDHSFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTV
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEE
AAQGGIAASLQNMTPDCWQWHLYDTVKGSDWLGDVDAMQYLAMEAPKAVYELEHYGVPFS
EECCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
RNEEGKIYQRPFGGHMQNYGEGPPVQRTCAAADRTGHAILHTLYGQSLRNNAEFFIEYFA
CCCCCCEEECCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
IDLIMSDDGRCTGVVAWNLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMI
EEEEECCCCCEEEEEEEECCCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTMEIREGRGVGKNKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPI
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGVPTNYWGEVLNADSQNPERIAPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAGQIIDRNAAVPEVDIAACDRIMDRFDRLRHANGATPTAVLRDKMQRAM
EEECCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QEDAAVFRTQESLESGCRRLSAIWKELPDIRVTDRSMIWNSDLVETLELENLMANAITTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHH
YGAEARKESRGAHAREDYKDGPLGGRDDVNWRKHTLAWVNDAGDVRLDFRPVHTELIAEG
HCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHCC
IDPYKIEPKARVY
CCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA