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The map label for this gene is atpA [H]

Identifier: 150398121

GI number: 150398121

Start: 3068490

End: 3070019

Strand: Reverse

Name: atpA [H]

Synonym: Smed_2924

Alternate gene names: 150398121

Gene position: 3070019-3068490 (Counterclockwise)

Preceding gene: 150398122

Following gene: 150398120

Centisome position: 81.18

GC content: 62.09

Gene sequence:

>1530_bases
ATGGATATCCGCGCCGCGGAAATTTCCGCTATTCTTAAAGATCAGATCAAAAATTTCGGCCAGGAAGCGGAAGTTTCCGA
AGTGGGTCAGGTGCTTTCCGTCGGTGACGGTATTGCCCGCGTCTACGGCCTCGACAACGTTCAGGCAGGCGAGATGGTCG
AATTCCCGGGCGGAATTCGCGGCATGGCGCTGAACCTGGAAGCCGACAATGTCGGCGTGGTCATCTTCGGTTCCGACCGT
GACATCAAGGAAGGTGACACCGTCAAGCGGACCGGAGCCATCGTGGACGTTCCGGTCGGCCCGGAACTGCTCGGCCGCGT
CGTGGACGCGCTCGGCAATCCGATCGACGGCAAGGGCCCGATCAATGCCAAGCAGCGTGCCCGCGTGGACGTCAAGGCGC
CCGGCATCATCCCGCGCAAGTCGGTTCACGAGCCGATGTCGACCGGCCTCAAGGCCATCGACGCACTGATCCCGGTTGGT
CGCGGCCAGCGCGAGCTCGTCATCGGCGATCGCCAGACCGGCAAGACCGCCATCATTCTCGACACGATCCTCAACCAGAA
GGCCATTCACGACAATGGGCCGGAAGGCGACAAGCTCTATTGCGTCTATGTCGCGATCGGCCAGAAGCGCTCGACGGTCG
CCCAGTTCGTGAAGGTGCTCGAGGAGCGCGGCGCGCTACAGTATTCGATCATCGTTGCTGCGACCGCTTCCGATGCCGCA
CCGATGCAGTACCTGGCGCCGTTTGCCGGTTGCACGATGGGCGAATATTTCCGTGACAGCGGCAAGCACGCCCTGATCGG
TTATGACGATCTCTCCAAGCAGGCCGTCGCCTACCGTCAGATGTCACTGCTGCTCCGCCGCCCGCCGGGCCGCGAAGCCT
ATCCCGGCGACGTCTTCTACCTGCATTCGCGCCTGCTGGAGCGTGCTGCAAAGCTCAACGACGACAATGGCGCCGGCTCG
CTGACGGCTCTGCCCGTCATCGAGACGCAGGGCAACGATGTTTCCGCGTTCATCCCGACCAACGTGATCTCGATCACCGA
CGGCCAGATCTTCCTTGAAACCGATCTGTTCTACCAGGGCATCCGCCCGGCCGTTAACGTCGGCCTGTCGGTCTCGCGTG
TCGGTTCCTCCGCCCAGATCAAGGCGATGAAGCAGGTCGCCGGTTCGATCAAGGGCGAGCTCGCCCAGTACCGCGAAATG
GCGGCCTTCGCACAGTTCGGTTCGGATCTCGACGCCGCGACGCAGCGCCTGCTCAACCGCGGTGCCCGTCTGACCGAACT
CCTGAAGCAGCCGCAGTTCTCGCCGCTGAAGACGGAAGAGCAGGTCGCGGTCATCTTTGCCGGCGTCAATGGCTTTCTCG
ATAAGCTGCCGGTCGCCGACGTGGGCAAGTTCGAGCAGGGTCTCCTTTCCTACATGCGTTCGGAAGGCAAGGCCGTTCTG
GATACCATCCGCACGGAAAAGGCGATCTCGGACGACACCAAGGCCAAATTGAAGGCCGCAATCGACAGCTTCGCCAAGTC
TTTCGCCTGA

Upstream 100 bases:

>100_bases
TTCTTGGAGGTCTGATCGTCAAGGTCGGTTCCCGCCAGATTGACACCTCCCTTCGCACCAAACTCTCTACCCTTAAGCTT
GCACTGAAAGAGGTCGGCTG

Downstream 100 bases:

>100_bases
GCGGACCTCAATTAGGACGGACAACGGATGCCTTCACTTAAGGATCTGAAGAACCGGATCGCCTCCGTCAAGGCGACGCA
GAAGATCACCAAGGCGATGA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAKQRARVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDAA
PMQYLAPFAGCTMGEYFRDSGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGFLDKLPVADVGKFEQGLLSYMRSEGKAVL
DTIRTEKAISDDTKAKLKAAIDSFAKSFA

Sequences:

>Translated_509_residues
MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAKQRARVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDAA
PMQYLAPFAGCTMGEYFRDSGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGFLDKLPVADVGKFEQGLLSYMRSEGKAVL
DTIRTEKAISDDTKAKLKAAIDSFAKSFA
>Mature_509_residues
MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
DIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAKQRARVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDAA
PMQYLAPFAGCTMGEYFRDSGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGFLDKLPVADVGKFEQGLLSYMRSEGKAVL
DTIRTEKAISDDTKAKLKAAIDSFAKSFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=72.1669980119284, Blast_Score=747, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=72.1669980119284, Blast_Score=747, Evalue=0.0,
Organism=Homo sapiens, GI19913426, Length=355, Percent_Identity=27.887323943662, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI32189394, Length=419, Percent_Identity=25.5369928400955, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI19913428, Length=352, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=55.1456310679612, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=25.3521126760563, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788251, Length=303, Percent_Identity=29.7029702970297, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=70.7753479125249, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=70.7753479125249, Blast_Score=733, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=65.2087475149105, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=334, Percent_Identity=26.6467065868263, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=297, Percent_Identity=27.6094276094276, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=377, Percent_Identity=25.4641909814324, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=57.8947368421053, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=64, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=70.3187250996016, Blast_Score=739, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=373, Percent_Identity=28.9544235924933, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322581, Length=404, Percent_Identity=25.4950495049505, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=72.0792079207921, Blast_Score=746, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=340, Percent_Identity=27.9411764705882, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646341, Length=340, Percent_Identity=27.9411764705882, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136796, Length=340, Percent_Identity=27.9411764705882, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24638766, Length=402, Percent_Identity=25.1243781094527, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574560, Length=393, Percent_Identity=25.1908396946565, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 54620; Mature: 54620

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEADNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INAKQRARVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDAA
HHHHCCHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
PMQYLAPFAGCTMGEYFRDSGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDDNGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGFLDKLPVADVGKFEQGLLSYMRSEGKAVL
CHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHH
DTIRTEKAISDDTKAKLKAAIDSFAKSFA
HHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEADNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INAKQRARVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDAA
HHHHCCHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
PMQYLAPFAGCTMGEYFRDSGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDDNGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGFLDKLPVADVGKFEQGLLSYMRSEGKAVL
CHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHH
DTIRTEKAISDDTKAKLKAAIDSFAKSFA
HHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]