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The map label for this gene is oxyR [H]

Identifier: 150398098

GI number: 150398098

Start: 3043566

End: 3044462

Strand: Reverse

Name: oxyR [H]

Synonym: Smed_2900

Alternate gene names: 150398098

Gene position: 3044462-3043566 (Counterclockwise)

Preceding gene: 150398099

Following gene: 150398097

Centisome position: 80.5

GC content: 59.31

Gene sequence:

>897_bases
ATGATCGACAAGCTGGAATTCTTTCTCGCACTTGCCCGGGAGCGGCACTTCGGCCGGGCGGCGGAGGAGTGCGGCGTGAC
GCAACCGACGCTTTCGGCGGCGATCCGTCAGCTTGAAGAACAGCTCGGCGTCATCCTGGTCAATCGCGGATCACGTTTCC
AGGGGCTGACACCCGAAGGGCAGCGGGTGCTGGAATGGGCACGGCGGATCGTCAGCGACACCCGTACGATGCGTGAAGAG
ATGCGTGCAGCCCGAAAAGGTCTGTCGGGTCATATCCGCCTCGCCGCAATACCGACGACACTCTCCATGGTGCCGATGAT
AACCGCACCGTTCCAGGAGAAGCATCCGGACGTCACTTTCTCCGTCCTTTCCACCACATCGCTGCAGATACTGGCGCTAC
TCGAAAACCTCGAGATCGATGCCGGCCTGACCTATCTCGAGAATGAGCCGCTCGGCCGGGTAACGAGCGTGCCGCTGCAG
ATCGAGCAATATCATCTGGTTACGGCCGCCGACACGGCCCTTTCGGATCGCGAAAGCGTGACCTGGAAGGAAGTGAGCGG
CATTCGGCTTTGTCTATTGACGGCCGATATGCAGAACCGCCGCATCATCAACCAGCACTTTGCAGAGGCCGGTGCGGTCC
CGAGCCCTACACTCGAATCGAATTCGATGATCGTGCTCTTCTCCCATGTCCGAACCGGACGATGGGCGAGCATCATGCCT
TTTAACGTAGCGAAATCATTCGGCTTTCACGAGGATATCCGGATGATACCGATTGTCGATCCGGACGTCCATCATACGGT
CGGGCTGGTCGCCACCTATCGTGAGCCGTTCACGCCCTTGGTCTCCGCACTGCTGCATGAGGCGCGCATGCTCGGTGAGC
GCAATAAAGCTCAATAG

Upstream 100 bases:

>100_bases
TCATCGCTTGAGCGCGCGTCCGCCCCCCATCCGCCTGCCGGTGCCTTCTCCCCGCCTGCGGGGGTGAGGGGCAAAAACGC
GTGCACTGAGTGAGCCGGTC

Downstream 100 bases:

>100_bases
AAATTTCCTATCGACCAACGGAACAGCCTTATTGACCCGTGGAAGCATACGCGCGAAGCTTATTTCCTGGGCAAAGAGCG
TGAAATCTCCGATCTTTGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MIDKLEFFLALARERHFGRAAEECGVTQPTLSAAIRQLEEQLGVILVNRGSRFQGLTPEGQRVLEWARRIVSDTRTMREE
MRAARKGLSGHIRLAAIPTTLSMVPMITAPFQEKHPDVTFSVLSTTSLQILALLENLEIDAGLTYLENEPLGRVTSVPLQ
IEQYHLVTAADTALSDRESVTWKEVSGIRLCLLTADMQNRRIINQHFAEAGAVPSPTLESNSMIVLFSHVRTGRWASIMP
FNVAKSFGFHEDIRMIPIVDPDVHHTVGLVATYREPFTPLVSALLHEARMLGERNKAQ

Sequences:

>Translated_298_residues
MIDKLEFFLALARERHFGRAAEECGVTQPTLSAAIRQLEEQLGVILVNRGSRFQGLTPEGQRVLEWARRIVSDTRTMREE
MRAARKGLSGHIRLAAIPTTLSMVPMITAPFQEKHPDVTFSVLSTTSLQILALLENLEIDAGLTYLENEPLGRVTSVPLQ
IEQYHLVTAADTALSDRESVTWKEVSGIRLCLLTADMQNRRIINQHFAEAGAVPSPTLESNSMIVLFSHVRTGRWASIMP
FNVAKSFGFHEDIRMIPIVDPDVHHTVGLVATYREPFTPLVSALLHEARMLGERNKAQ
>Mature_298_residues
MIDKLEFFLALARERHFGRAAEECGVTQPTLSAAIRQLEEQLGVILVNRGSRFQGLTPEGQRVLEWARRIVSDTRTMREE
MRAARKGLSGHIRLAAIPTTLSMVPMITAPFQEKHPDVTFSVLSTTSLQILALLENLEIDAGLTYLENEPLGRVTSVPLQ
IEQYHLVTAADTALSDRESVTWKEVSGIRLCLLTADMQNRRIINQHFAEAGAVPSPTLESNSMIVLFSHVRTGRWASIMP
FNVAKSFGFHEDIRMIPIVDPDVHHTVGLVATYREPFTPLVSALLHEARMLGERNKAQ

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=282, Percent_Identity=29.7872340425532, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI157672245, Length=286, Percent_Identity=27.972027972028, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693105, Length=270, Percent_Identity=25.5555555555556, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=241, Percent_Identity=26.9709543568465, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367136, Length=178, Percent_Identity=32.5842696629214, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786401, Length=144, Percent_Identity=32.6388888888889, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081904, Length=149, Percent_Identity=30.8724832214765, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081978, Length=94, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787879, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788296, Length=211, Percent_Identity=26.5402843601896, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787806, Length=264, Percent_Identity=23.4848484848485, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788887, Length=251, Percent_Identity=23.9043824701195, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33329; Mature: 33329

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKLEFFLALARERHFGRAAEECGVTQPTLSAAIRQLEEQLGVILVNRGSRFQGLTPEG
CCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCH
QRVLEWARRIVSDTRTMREEMRAARKGLSGHIRLAAIPTTLSMVPMITAPFQEKHPDVTF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCHHCCCCEEE
SVLSTTSLQILALLENLEIDAGLTYLENEPLGRVTSVPLQIEQYHLVTAADTALSDRESV
EEHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEECCCEEEEEEEEEEEHHHHHCCCCCC
TWKEVSGIRLCLLTADMQNRRIINQHFAEAGAVPSPTLESNSMIVLFSHVRTGRWASIMP
CHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEECC
FNVAKSFGFHEDIRMIPIVDPDVHHTVGLVATYREPFTPLVSALLHEARMLGERNKAQ
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIDKLEFFLALARERHFGRAAEECGVTQPTLSAAIRQLEEQLGVILVNRGSRFQGLTPEG
CCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCH
QRVLEWARRIVSDTRTMREEMRAARKGLSGHIRLAAIPTTLSMVPMITAPFQEKHPDVTF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCHHCCCCEEE
SVLSTTSLQILALLENLEIDAGLTYLENEPLGRVTSVPLQIEQYHLVTAADTALSDRESV
EEHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEECCCEEEEEEEEEEEHHHHHCCCCCC
TWKEVSGIRLCLLTADMQNRRIINQHFAEAGAVPSPTLESNSMIVLFSHVRTGRWASIMP
CHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEECC
FNVAKSFGFHEDIRMIPIVDPDVHHTVGLVATYREPFTPLVSALLHEARMLGERNKAQ
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]