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The map label for this gene is hemA [H]

Identifier: 150398078

GI number: 150398078

Start: 3014115

End: 3015335

Strand: Reverse

Name: hemA [H]

Synonym: Smed_2880

Alternate gene names: 150398078

Gene position: 3015335-3014115 (Counterclockwise)

Preceding gene: 150398079

Following gene: 150398076

Centisome position: 79.73

GC content: 61.34

Gene sequence:

>1221_bases
ATGATGATGGATTTCGAGAGTTTCTTCAAAAACGAGCTGGATGGGCTGCATCAGGAAGGTCGATACAGGGTTTTCGCCGA
TCTCGCCCGTCATCGCGGCAACTTCCCCAAGGCGACGCGCTATACGGCCGAAGGCGCCCAGGAAGTGACTGTCTGGTGCT
CGAACGATTATCTCGGCATGGGTCAGTGTCCCATCGTCACCGACGCGATGAAGCAGGCGATCGACGAATGCGGCGCCGGC
GCCGGCGGAACCCGCAACATTTCCGGAACCAACCATTACCATGTGATGCTCGAGCGCGAACTTGCCGACCTGCACGGCAA
GGAATCGGCGCTTCTGTTCACCTCCGGTTACGTTTCGAACTGGGCAGCGCTCGGGACGCTCTGTTCCAAGCTTCCCGGCG
TCATCGTCTTTTCAGATGCCGGCAACCACGCTTCGATGATCGAAGGCATTCGTCACTCGAAATGCGAGCGGGTCATTTTC
AAGCACAATTCGGTGGCGGATCTCGAGGCGAAGCTTGCAGCCGCCGATCCGCGCGCGCCAAAGATCATCGCCTTCGAGTC
CGTCTATTCGATGGATGGCGACATCGCGCCGATCAAGGAATTCTGCGACCTCGCGGACAAATACGGGGCGATGACATACC
TGGATGAAGTGCACGCGGTCGGCATGTACGGGCCGCGCGGCGGCGGCATCGCCGAGCGCGAAGGGCTGATGCACCGGCTG
ACCGTCATCGAAGGCACGCTCGGCAAAGCCTTCGGCGTCATGGGCGGCTACATCACCGGATCGGCCGCGCTCTGCGATTT
CATCCGCTCCTTTGCGTCCGGCTTCATCTTCACCACGGCGCTGCCGCCGGCGCTTGCCGCCGGTGCGCTCGCCTCCATTC
GCCACCTCAAGGAAAGCCAGACCGAACGCTTCGCGCATCAGGAGCGCGTGCGTCGGCTGCGCTCGCTGCTCGATCAGCGC
GGCATTCCGCATATGGTGAATCCCAGCCACATCGTGCCGGTCATCGTCGGCGATGCGGCCAAGTGCAAATGGATTTCCGA
CCTGTTGCTCGACAATTTCGGGGTTTATGTCCAGCCAATCAACTATCCGACGGTGCCGAAGAAGACCGAACGCCTGCGCA
TCACGCCGACCCCCTTGCATTCGGATGCCGATATCGACCACTTGGTGGGCGCACTGCATTCGCTCTGGTCGCGCTGCGCG
CTCGCAAGGGCGGTGGCGTAA

Upstream 100 bases:

>100_bases
TTGGAGGCTGAGAGGCCTTTTGCCGCAGCCCACGCGGCGGAGCCTGTCCGGGGTTGACCCCTGATCGCTTTGAAGGAAGA
AAGGCGGCAGGGCACTGGAG

Downstream 100 bases:

>100_bases
GGCTCACCCGGCCTCTCTCAATCGCGGCAACGCTTGTGTGGGGCGAGGCGCACCGCCACTTGTCCCTTTGCCCGGCCTGC
GTCCAGAAGGTCCGGCAGGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MMMDFESFFKNELDGLHQEGRYRVFADLARHRGNFPKATRYTAEGAQEVTVWCSNDYLGMGQCPIVTDAMKQAIDECGAG
AGGTRNISGTNHYHVMLERELADLHGKESALLFTSGYVSNWAALGTLCSKLPGVIVFSDAGNHASMIEGIRHSKCERVIF
KHNSVADLEAKLAAADPRAPKIIAFESVYSMDGDIAPIKEFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMHRL
TVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLKESQTERFAHQERVRRLRSLLDQR
GIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGVYVQPINYPTVPKKTERLRITPTPLHSDADIDHLVGALHSLWSRCA
LARAVA

Sequences:

>Translated_406_residues
MMMDFESFFKNELDGLHQEGRYRVFADLARHRGNFPKATRYTAEGAQEVTVWCSNDYLGMGQCPIVTDAMKQAIDECGAG
AGGTRNISGTNHYHVMLERELADLHGKESALLFTSGYVSNWAALGTLCSKLPGVIVFSDAGNHASMIEGIRHSKCERVIF
KHNSVADLEAKLAAADPRAPKIIAFESVYSMDGDIAPIKEFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMHRL
TVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLKESQTERFAHQERVRRLRSLLDQR
GIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGVYVQPINYPTVPKKTERLRITPTPLHSDADIDHLVGALHSLWSRCA
LARAVA
>Mature_406_residues
MMMDFESFFKNELDGLHQEGRYRVFADLARHRGNFPKATRYTAEGAQEVTVWCSNDYLGMGQCPIVTDAMKQAIDECGAG
AGGTRNISGTNHYHVMLERELADLHGKESALLFTSGYVSNWAALGTLCSKLPGVIVFSDAGNHASMIEGIRHSKCERVIF
KHNSVADLEAKLAAADPRAPKIIAFESVYSMDGDIAPIKEFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMHRL
TVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLKESQTERFAHQERVRRLRSLLDQR
GIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGVYVQPINYPTVPKKTERLRITPTPLHSDADIDHLVGALHSLWSRCA
LARAVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=404, Percent_Identity=49.7524752475247, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI83977440, Length=404, Percent_Identity=49.7524752475247, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI83977444, Length=404, Percent_Identity=49.7524752475247, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI4502025, Length=402, Percent_Identity=50, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI40316939, Length=402, Percent_Identity=50, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI7657118, Length=392, Percent_Identity=35.2040816326531, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI284448556, Length=342, Percent_Identity=38.8888888888889, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4758668, Length=416, Percent_Identity=29.0865384615385, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI119220554, Length=422, Percent_Identity=27.4881516587678, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=28.4584980237154, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1790046, Length=377, Percent_Identity=33.1564986737401, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1786993, Length=358, Percent_Identity=32.4022346368715, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=34.5088161209068, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566772, Length=427, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=392, Percent_Identity=27.2959183673469, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=392, Percent_Identity=27.2959183673469, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=25.9124087591241, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=25.9124087591241, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=46.8085106382979, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320267, Length=359, Percent_Identity=27.8551532033426, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=24.5421245421245, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137420, Length=405, Percent_Identity=48.3950617283951, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=34.9162011173184, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI17136286, Length=364, Percent_Identity=29.6703296703297, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653280, Length=259, Percent_Identity=26.2548262548263, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653276, Length=259, Percent_Identity=26.2548262548263, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653278, Length=259, Percent_Identity=26.2548262548263, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44350; Mature: 44350

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMDFESFFKNELDGLHQEGRYRVFADLARHRGNFPKATRYTAEGAQEVTVWCSNDYLGM
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCC
GQCPIVTDAMKQAIDECGAGAGGTRNISGTNHYHVMLERELADLHGKESALLFTSGYVSN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCEEEEECCHHHH
WAALGTLCSKLPGVIVFSDAGNHASMIEGIRHSKCERVIFKHNSVADLEAKLAAADPRAP
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
KIIAFESVYSMDGDIAPIKEFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMHRL
EEEEEHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLKESQ
HHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHH
TERFAHQERVRRLRSLLDQRGIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGVYVQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEC
NYPTVPKKTERLRITPTPLHSDADIDHLVGALHSLWSRCALARAVA
CCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMMDFESFFKNELDGLHQEGRYRVFADLARHRGNFPKATRYTAEGAQEVTVWCSNDYLGM
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCC
GQCPIVTDAMKQAIDECGAGAGGTRNISGTNHYHVMLERELADLHGKESALLFTSGYVSN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCEEEEECCHHHH
WAALGTLCSKLPGVIVFSDAGNHASMIEGIRHSKCERVIFKHNSVADLEAKLAAADPRAP
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
KIIAFESVYSMDGDIAPIKEFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAEREGLMHRL
EEEEEHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLKESQ
HHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHH
TERFAHQERVRRLRSLLDQRGIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGVYVQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEC
NYPTVPKKTERLRITPTPLHSDADIDHLVGALHSLWSRCALARAVA
CCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430; 2994020 [H]