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The map label for this gene is ptxR [H]

Identifier: 150397971

GI number: 150397971

Start: 2893045

End: 2893959

Strand: Direct

Name: ptxR [H]

Synonym: Smed_2773

Alternate gene names: 150397971

Gene position: 2893045-2893959 (Clockwise)

Preceding gene: 150397968

Following gene: 150397972

Centisome position: 76.5

GC content: 60.0

Gene sequence:

>915_bases
ATGCACAGAGAAAGACGAATCATGGATACCTTGACCCGCATCCGCGCTTTCATCGACGTCGTGGACGCGGAAGGCTTTTC
GGCAGCGGCCCGGCGGATCGGCAAATCCAAGGCGCTCCTGTCGAAATATGTGCGCGAACTCGAGGACGAGCTCGGCGCGC
TGCTCTTGAACCGCACGACGCGCCAATTCTCGCTGACCGAGGCCGGCCACACCTATTACCGCAGCGCATCGGAGATCCTG
AAGGAGATCGACAACCTCGCCGATCTTGTGCGCGCCAGTAATTCCGATCTCAAGGGCAGACTCCGAATCACCGTACCGAG
GACCTTCGTGGACGCGGATATCGGCCAGTCGCTGATAGACTTCGGCAAGGAGCACCCCGAACTTTCGCTCGAAATCGTCT
CCGACGACCGGTTCGTCGACCTCGTCGAGGAGAGTTTCGATGTCGCCATCCGCATCACCCGACTGGAGGATTCGACGCTG
ATCGCCCGCAAGCTCGATGACTTCCAGGTGCTGGTCTGCGCATCGCCGGATTTCATATCCAGGGCCGACCCTCTCATACA
TCCAAGTGAGCTTTCAAAACTCCCATGTATCCTCGACACCAACGGCCGGTCCTATTCTAGCTGGCGTTTCGTCGAAAAGG
ACGGTTCGCCCTTCACGGTATCCGTGAGCGGACAGATCGAAGTCAACAGCCCGCTTGGCGCGGCACGCGCCGCCGTGACA
GGCATCGGGGTGGCAGTCCTTCCCGATTTCATCGCCCGCCCGAAGATCGCGTCCGGCGAGCTCGTCACCCTCTTCGACGA
TTTCCTGCCCAAGGACCGCGGCATCTATGCGATTTATCCGCATCGCCGCTACCTGCCGACCAAGGTTCGCACCTTCGTCG
ATTTTCTCCACAACTGGTTCCGCAGCACCCGCTGA

Upstream 100 bases:

>100_bases
GAGTTTTTTCCGTTCTTCAATAAATATTTCTGGACCTCGGCCAGAGCGCCGGTGTTCACTTTCGCTGAACAATCGCAGGA
AGACCGCTGATGCGGCCGGA

Downstream 100 bases:

>100_bases
TGAGACCGCAAACCTTTACGACCCCGATGAAAACCATGCGCCGCAAGTCCCAATTCCGTCTCATTTACGGTACATTCGGA
AGACGATTCGCACGGCTCCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHRERRIMDTLTRIRAFIDVVDAEGFSAAARRIGKSKALLSKYVRELEDELGALLLNRTTRQFSLTEAGHTYYRSASEIL
KEIDNLADLVRASNSDLKGRLRITVPRTFVDADIGQSLIDFGKEHPELSLEIVSDDRFVDLVEESFDVAIRITRLEDSTL
IARKLDDFQVLVCASPDFISRADPLIHPSELSKLPCILDTNGRSYSSWRFVEKDGSPFTVSVSGQIEVNSPLGAARAAVT
GIGVAVLPDFIARPKIASGELVTLFDDFLPKDRGIYAIYPHRRYLPTKVRTFVDFLHNWFRSTR

Sequences:

>Translated_304_residues
MHRERRIMDTLTRIRAFIDVVDAEGFSAAARRIGKSKALLSKYVRELEDELGALLLNRTTRQFSLTEAGHTYYRSASEIL
KEIDNLADLVRASNSDLKGRLRITVPRTFVDADIGQSLIDFGKEHPELSLEIVSDDRFVDLVEESFDVAIRITRLEDSTL
IARKLDDFQVLVCASPDFISRADPLIHPSELSKLPCILDTNGRSYSSWRFVEKDGSPFTVSVSGQIEVNSPLGAARAAVT
GIGVAVLPDFIARPKIASGELVTLFDDFLPKDRGIYAIYPHRRYLPTKVRTFVDFLHNWFRSTR
>Mature_304_residues
MHRERRIMDTLTRIRAFIDVVDAEGFSAAARRIGKSKALLSKYVRELEDELGALLLNRTTRQFSLTEAGHTYYRSASEIL
KEIDNLADLVRASNSDLKGRLRITVPRTFVDADIGQSLIDFGKEHPELSLEIVSDDRFVDLVEESFDVAIRITRLEDSTL
IARKLDDFQVLVCASPDFISRADPLIHPSELSKLPCILDTNGRSYSSWRFVEKDGSPFTVSVSGQIEVNSPLGAARAAVT
GIGVAVLPDFIARPKIASGELVTLFDDFLPKDRGIYAIYPHRRYLPTKVRTFVDFLHNWFRSTR

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=287, Percent_Identity=34.1463414634146, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789639, Length=293, Percent_Identity=31.0580204778157, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI87081978, Length=291, Percent_Identity=32.6460481099656, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=29.8969072164948, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789440, Length=290, Percent_Identity=27.9310344827586, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787589, Length=289, Percent_Identity=31.1418685121107, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787128, Length=283, Percent_Identity=26.1484098939929, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789173, Length=268, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788706, Length=305, Percent_Identity=24.2622950819672, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790011, Length=290, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787601, Length=138, Percent_Identity=29.7101449275362, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI157672245, Length=148, Percent_Identity=33.1081081081081, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082132, Length=297, Percent_Identity=22.8956228956229, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786448, Length=291, Percent_Identity=24.0549828178694, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788748, Length=137, Percent_Identity=29.9270072992701, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34275; Mature: 34275

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRERRIMDTLTRIRAFIDVVDAEGFSAAARRIGKSKALLSKYVRELEDELGALLLNRTT
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
RQFSLTEAGHTYYRSASEILKEIDNLADLVRASNSDLKGRLRITVPRTFVDADIGQSLID
CEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHH
FGKEHPELSLEIVSDDRFVDLVEESFDVAIRITRLEDSTLIARKLDDFQVLVCASPDFIS
CCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCHHEEECCCEEEEEECCCCHHH
RADPLIHPSELSKLPCILDTNGRSYSSWRFVEKDGSPFTVSVSGQIEVNSPLGAARAAVT
CCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCEEEEEEEEEEEECCCCCHHHHHHH
GIGVAVLPDFIARPKIASGELVTLFDDFLPKDRGIYAIYPHRRYLPTKVRTFVDFLHNWF
HCHHHHHHHHHCCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
RSTR
HCCC
>Mature Secondary Structure
MHRERRIMDTLTRIRAFIDVVDAEGFSAAARRIGKSKALLSKYVRELEDELGALLLNRTT
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
RQFSLTEAGHTYYRSASEILKEIDNLADLVRASNSDLKGRLRITVPRTFVDADIGQSLID
CEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHH
FGKEHPELSLEIVSDDRFVDLVEESFDVAIRITRLEDSTLIARKLDDFQVLVCASPDFIS
CCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCHHEEECCCEEEEEECCCCHHH
RADPLIHPSELSKLPCILDTNGRSYSSWRFVEKDGSPFTVSVSGQIEVNSPLGAARAAVT
CCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCEEEEEEEEEEEECCCCCHHHHHHH
GIGVAVLPDFIARPKIASGELVTLFDDFLPKDRGIYAIYPHRRYLPTKVRTFVDFLHNWF
HCHHHHHHHHHCCCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
RSTR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]