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The map label for this gene is pntAA [H]

Identifier: 150397957

GI number: 150397957

Start: 2878011

End: 2879159

Strand: Reverse

Name: pntAA [H]

Synonym: Smed_2759

Alternate gene names: 150397957

Gene position: 2879159-2878011 (Counterclockwise)

Preceding gene: 150397958

Following gene: 150397956

Centisome position: 76.13

GC content: 64.23

Gene sequence:

>1149_bases
GTGAGCGAAATCGTCTTTATCGCCAAGGAATCGGATCCGAACGAGGGGCGCGTTGCCGGTTCCATCGATAGCGTGAAAAA
GCTTAAGTCACTCGGCTTCGACGTCGTCGTCGAATCGGGTGCCGGCCAAGGGTCGCGAATACCCGATCAGGACTACGAGA
AGGCCGGTGCACGGATCGGCAAGGCGACCGATGCGAAGACCGCTGACGTGATCCTCAAGGTTCGCCGGCCGAGTGCGCAG
GAAGTTGCCGGCTACCGATCGGGCGCGATCGTCATCGCGATCATGGATCCTTACGGGAACGAGGAGTCGATATCGGCGAT
GGCCGGTGCGGGCCTCACATCCTTCGCCATGGAGCTGATGCCGCGTATCACCCGCGCGCAATCCATGGATGTGCTTTCCA
GCCAGGCAAACCTCGCCGGTTACCAGGCGGTGATCGATGCCGCCAATGAGTACGACCGGGCGCTGCCGATGATGATGACG
GCGGCCGGCACTGTGCCGGCGGCCAAGGTCTTCGTTATGGGGGCGGGCGTTGCCGGCCTGCAGGCGATCGCCACCGCTCG
CCGACTGGGCGCCGTCGTCTCGGCGACGGACGTCCGGCCTGCCGCCAAAGAGCAGGTCGCCTCTCTCGGCGCCAAGTTCA
TCGCCGTCGAGGACGAGGAGTTCAAGGCCGCCGAGACTGCCGGCGGCTATGCCAAGGAGATGTCCGGGGAATATCAGGCC
AAGCAGGCTGCGCTTGTCGCCGAGCACATCGCCAAGCAGGACATTGTCATCACCACGGCGCTGATCCCCGGCCGGCCGGC
ACCACGGCTCGTGACCCGCGAAATGCTCGATTCGATGAAGCCGGGCTCCGTCGCCGTCGATCTCGCGGTCGAGCGCGGCG
GCAATATCGAGGGAGCGGAAGCCGGCAAGGTGACGGAGGTCGGGGGCGTCAAGATCGTCGGCCATCTGAACGTGCCTGGC
CGCATCGCGGCTTCCGCATCGCTGCTTTACGCCAAGAACCTCGTCACCTTCTTGGAGACGATGGTCTCGAAGGAGACGAA
GGCGCTGGCGTTGAACATGGAGGATGAGCTCGTAAAGGCTACGGCACTGACTCACGGCGGGTCCGTCGTGCATCCGGCCT
TCGGCGGTGCCATGAAGGGGGAGAAGTAA

Upstream 100 bases:

>100_bases
TTCGGGAGGCCCATGTGAATTTGAGGGGCGGCTGAAGGCTGTCGCCTGGAGGACAACGTCCGCAACCCGGCCTGCCGGGC
CGGGCCAGGGAGGGGGATTT

Downstream 100 bases:

>100_bases
ATGGCGAACGAACTTCTGGACAAGGCGCTCGTCGATCTTGAACGGGCAGTCGAGGCGGTGAGGACCGCCGCCGAATACGT
ACCGGATGCGGCCGGAGCGG

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSEIVFIAKESDPNEGRVAGSIDSVKKLKSLGFDVVVESGAGQGSRIPDQDYEKAGARIGKATDAKTADVILKVRRPSAQ
EVAGYRSGAIVIAIMDPYGNEESISAMAGAGLTSFAMELMPRITRAQSMDVLSSQANLAGYQAVIDAANEYDRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVSATDVRPAAKEQVASLGAKFIAVEDEEFKAAETAGGYAKEMSGEYQA
KQAALVAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVAVDLAVERGGNIEGAEAGKVTEVGGVKIVGHLNVPG
RIAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKATALTHGGSVVHPAFGGAMKGEK

Sequences:

>Translated_382_residues
MSEIVFIAKESDPNEGRVAGSIDSVKKLKSLGFDVVVESGAGQGSRIPDQDYEKAGARIGKATDAKTADVILKVRRPSAQ
EVAGYRSGAIVIAIMDPYGNEESISAMAGAGLTSFAMELMPRITRAQSMDVLSSQANLAGYQAVIDAANEYDRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVSATDVRPAAKEQVASLGAKFIAVEDEEFKAAETAGGYAKEMSGEYQA
KQAALVAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVAVDLAVERGGNIEGAEAGKVTEVGGVKIVGHLNVPG
RIAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKATALTHGGSVVHPAFGGAMKGEK
>Mature_381_residues
SEIVFIAKESDPNEGRVAGSIDSVKKLKSLGFDVVVESGAGQGSRIPDQDYEKAGARIGKATDAKTADVILKVRRPSAQE
VAGYRSGAIVIAIMDPYGNEESISAMAGAGLTSFAMELMPRITRAQSMDVLSSQANLAGYQAVIDAANEYDRALPMMMTA
AGTVPAAKVFVMGAGVAGLQAIATARRLGAVVSATDVRPAAKEQVASLGAKFIAVEDEEFKAAETAGGYAKEMSGEYQAK
QAALVAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVAVDLAVERGGNIEGAEAGKVTEVGGVKIVGHLNVPGR
IAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKATALTHGGSVVHPAFGGAMKGEK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=381, Percent_Identity=39.6325459317585, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI122939153, Length=381, Percent_Identity=39.6325459317585, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787887, Length=368, Percent_Identity=43.2065217391304, Blast_Score=297, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=365, Percent_Identity=43.8356164383562, Blast_Score=285, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39634; Mature: 39503

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIVFIAKESDPNEGRVAGSIDSVKKLKSLGFDVVVESGAGQGSRIPDQDYEKAGARIG
CCCEEEEEECCCCCCCCEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCC
KATDAKTADVILKVRRPSAQEVAGYRSGAIVIAIMDPYGNEESISAMAGAGLTSFAMELM
CCCCCCCEEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHH
PRITRAQSMDVLSSQANLAGYQAVIDAANEYDRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVSATDVRPAAKEQVASLGAKFIAVEDEEFKAAETAGGYAKEMSGEYQA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHCCCHHHHHCCHHHH
KQAALVAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVAVDLAVERGGNIEGAE
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCC
AGKVTEVGGVKIVGHLNVPGRIAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKA
CCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
TALTHGGSVVHPAFGGAMKGEK
HHCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
SEIVFIAKESDPNEGRVAGSIDSVKKLKSLGFDVVVESGAGQGSRIPDQDYEKAGARIG
CCEEEEEECCCCCCCCEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCC
KATDAKTADVILKVRRPSAQEVAGYRSGAIVIAIMDPYGNEESISAMAGAGLTSFAMELM
CCCCCCCEEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHH
PRITRAQSMDVLSSQANLAGYQAVIDAANEYDRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVSATDVRPAAKEQVASLGAKFIAVEDEEFKAAETAGGYAKEMSGEYQA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHCCCHHHHHCCHHHH
KQAALVAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVAVDLAVERGGNIEGAE
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCC
AGKVTEVGGVKIVGHLNVPGRIAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKA
CCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
TALTHGGSVVHPAFGGAMKGEK
HHCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]