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The map label for this gene is pntB [H]

Identifier: 150397955

GI number: 150397955

Start: 2876187

End: 2877590

Strand: Reverse

Name: pntB [H]

Synonym: Smed_2757

Alternate gene names: 150397955

Gene position: 2877590-2876187 (Counterclockwise)

Preceding gene: 150397956

Following gene: 150397950

Centisome position: 76.09

GC content: 61.75

Gene sequence:

>1404_bases
ATGAACGCTAATTTTGCTGCCTTCCTCTATCTCGTCTCGGGCGTGCTCTTCATCATGGCGCTGCGCGGGCTCTCGCATCC
GACCACCAGCCGCAAAGGCAATACTTACGGCATGGTCGGCATGGGCATCGCGATCATCACGACGCTGTTCCTTGCACAGC
CATCGATCGGCGGCTTCCTGCTGATCGTCGCCGGTCTTGCCATCGGCGGCGGTGCGGGCGCCTATATCGCCAAGCGCATC
CCGATGACGGCGATGCCGCAGCTCGTTGCCGGCTTCCACTCCCTCGTCGGTCTCGCCGCCGTGCTGGTAGCGGCGGCCGC
GCTCTACGCGCCATCCTCCTTCGGCATCGGCGACGTCGGTTCGATTCCCACTCAGGCACTCGTCGAAATGGCGCTCGGAG
TGGCGATCGGCGCCATCACGTTCACAGGCTCGATCATCGCTTTCCTGAAGCTCGATGGGCGTATGTCGGGAAAACCCATC
CTTCTGCCTTACCGCCACGCGATCAATCTCGCGCTTGCCGCACTCGTCGTATTCTTCATCATCGGGCTGGCGTTGAGCGA
AAGCCACTTCGACTTCTGGGCGATCGTCGCCCTGTCGCTGGCCCTCGGCGTTCTGATCATCGTCCCGATCGGCGGCGCGG
ACATGCCCGTCGTCGTGTCCATGCTGAACTCCTATTCCGGCTGGGCGGCGGCCGGCATCGGATTCACCCTCGGCAATCTG
GCGCTCATCATTACCGGCGCGCTGGTCGGCTCCTCCGGTGCGATCCTCTCCTACATCATGTGCAAGGGCATGAACCGTTC
GTTCATTTCGGTCATCCTCGGCGGCTTCGGCGGCGAGACCGCGGCGGCCGGTGGTGCCGACGACGGAGTAGCGAGAACGG
TGAAGCAGGGTTCTGCAGACGACGCAGCCTTCCTGATGCAGAATGCCTCGAAGGTGATCATCGTCCCGGGCTACGGCATG
GCGGTTGCCCAGGCTCAGCACGCTCTGCGTGAACTTGCGGACAAGCTCAAGGAGAACGGTGTCGAGGTCAAATACGCGAT
CCATCCGGTCGCCGGCCGCATGCCTGGACACATGAACGTACTGCTCGCCGAAGCGAACGTTCCTTACGACGAGGTGTTCG
AACTGGAGGACATCAATTCGGAATTCGCCCAGGCCGATGTCGCCTATGTCATAGGCGCCAACGACGTCACCAATCCGGCG
GCTCGCGACGACAAGTCCTCGCCGATCTACGGCATGCCGATCCTCGACGTCGACAAGGCGAAAACCTGCCTCTTCGTCAA
GCGTTCGCTTGGCTCCGGCTATGCCGGCATCGACAACACGCTGTTCTATAAGGACGGTACGATGATGCTGCTCGGCGATG
CCAAGAAGATGACGGAGGAGATCGTCAAGGCGATCAATCACTGA

Upstream 100 bases:

>100_bases
CGTCGCGCTGGTGCTTGCTTCGGTGAACATATTCGGTGGCTTCCTGGTCACTCAGCGCATGCTTGCCATGTACAAGAAAA
AAGAAAAGTGAGGCGGGCCG

Downstream 100 bases:

>100_bases
CGGCCGCCTCCGGTTCTCGCGGTGAACGGCACGGCTCTTAGCCGATGCCGGGTGGCGGCGGAGTCGCAAGGGCCAGGGCG
ATGGGTTTGTGGGCCTTGAA

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNANFAAFLYLVSGVLFIMALRGLSHPTTSRKGNTYGMVGMGIAIITTLFLAQPSIGGFLLIVAGLAIGGGAGAYIAKRI
PMTAMPQLVAGFHSLVGLAAVLVAAAALYAPSSFGIGDVGSIPTQALVEMALGVAIGAITFTGSIIAFLKLDGRMSGKPI
LLPYRHAINLALAALVVFFIIGLALSESHFDFWAIVALSLALGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAGGADDGVARTVKQGSADDAAFLMQNASKVIIVPGYGM
AVAQAQHALRELADKLKENGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAYVIGANDVTNPA
ARDDKSSPIYGMPILDVDKAKTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEEIVKAINH

Sequences:

>Translated_467_residues
MNANFAAFLYLVSGVLFIMALRGLSHPTTSRKGNTYGMVGMGIAIITTLFLAQPSIGGFLLIVAGLAIGGGAGAYIAKRI
PMTAMPQLVAGFHSLVGLAAVLVAAAALYAPSSFGIGDVGSIPTQALVEMALGVAIGAITFTGSIIAFLKLDGRMSGKPI
LLPYRHAINLALAALVVFFIIGLALSESHFDFWAIVALSLALGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAGGADDGVARTVKQGSADDAAFLMQNASKVIIVPGYGM
AVAQAQHALRELADKLKENGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAYVIGANDVTNPA
ARDDKSSPIYGMPILDVDKAKTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEEIVKAINH
>Mature_467_residues
MNANFAAFLYLVSGVLFIMALRGLSHPTTSRKGNTYGMVGMGIAIITTLFLAQPSIGGFLLIVAGLAIGGGAGAYIAKRI
PMTAMPQLVAGFHSLVGLAAVLVAAAALYAPSSFGIGDVGSIPTQALVEMALGVAIGAITFTGSIIAFLKLDGRMSGKPI
LLPYRHAINLALAALVVFFIIGLALSESHFDFWAIVALSLALGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAGGADDGVARTVKQGSADDAAFLMQNASKVIIVPGYGM
AVAQAQHALRELADKLKENGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAYVIGANDVTNPA
ARDDKSSPIYGMPILDVDKAKTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEEIVKAINH

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=468, Percent_Identity=45.7264957264957, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI122939153, Length=468, Percent_Identity=45.7264957264957, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1787886, Length=465, Percent_Identity=52.4731182795699, Blast_Score=454, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17550456, Length=465, Percent_Identity=46.2365591397849, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48381; Mature: 48381

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANFAAFLYLVSGVLFIMALRGLSHPTTSRKGNTYGMVGMGIAIITTLFLAQPSIGGFL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
LIVAGLAIGGGAGAYIAKRIPMTAMPQLVAGFHSLVGLAAVLVAAAALYAPSSFGIGDVG
HHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIPTQALVEMALGVAIGAITFTGSIIAFLKLDGRMSGKPILLPYRHAINLALAALVVFFI
CCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHH
IGLALSESHFDFWAIVALSLALGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
HHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAGGADDGVARTVKQGSAD
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCC
DAAFLMQNASKVIIVPGYGMAVAQAQHALRELADKLKENGVEVKYAIHPVAGRMPGHMNV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEE
LLAEANVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAARDDKSSPIYGMPILDVDKA
EEEECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCEECCCC
KTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEEIVKAINH
HHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNANFAAFLYLVSGVLFIMALRGLSHPTTSRKGNTYGMVGMGIAIITTLFLAQPSIGGFL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
LIVAGLAIGGGAGAYIAKRIPMTAMPQLVAGFHSLVGLAAVLVAAAALYAPSSFGIGDVG
HHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIPTQALVEMALGVAIGAITFTGSIIAFLKLDGRMSGKPILLPYRHAINLALAALVVFFI
CCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHH
IGLALSESHFDFWAIVALSLALGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
HHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAGGADDGVARTVKQGSAD
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCC
DAAFLMQNASKVIIVPGYGMAVAQAQHALRELADKLKENGVEVKYAIHPVAGRMPGHMNV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEE
LLAEANVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAARDDKSSPIYGMPILDVDKA
EEEECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCEECCCC
KTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEEIVKAINH
HHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]