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The map label for this gene is pgm [H]

Identifier: 150397941

GI number: 150397941

Start: 2859579

End: 2861207

Strand: Direct

Name: pgm [H]

Synonym: Smed_2743

Alternate gene names: 150397941

Gene position: 2859579-2861207 (Clockwise)

Preceding gene: 150397940

Following gene: 150397942

Centisome position: 75.61

GC content: 62.12

Gene sequence:

>1629_bases
ATGACAAGAACCGTCTCCACCAATCCTTATAGCGACCAGAAGCCGGGCACCTCTGGCCTGCGCAAGAAAGTTCCGGTTTT
CCAGCAGAAAAATTATGCCGAGAACTTCATCCAGTCGATCTTCGACTCGCTTGATGGCTTCGAAGGCCAGACGCTGGTGA
TCGGCGGCGATGGCCGCTACTACAACCGCGAGGTCATTCAGAAGGCTATCAAGATGGCGGCCGCGAACGGCTTTGGCCGT
GTGCTCGTCGGCCGCGGCGGCATTCTCTCGACTCCGGCCGCGTCCCATGTCATCCGCAAGTACAAGGCGTTCGGCGGCAT
CGTGCTTTCGGCGAGCCACAATCCCGGCGGCCCCACCGAAGACTTCGGCATCAAGTACAATGTCGGCAATGGCGGCCCGG
CCCCCGAAAAGGTCACCGACGCGATCTTTGCCCGCAGCAAGACGATCGACAGCTACAGGATCGTCGACGCGCCGGACGTG
AACCTCGACGCGGAAGGCAGCCATCAGGTCGACGACATGACGGTGACCGTCATCGATCCGGTCGCCGATTATGCCGAGTT
GATGGAAAGCCTGTTCGACTTCGATGCGATCCGCAAACTGATCGCGGGCGGCTTCCGCGTCGTCTTCGACGCCATGAGCG
CAGTCACCGGGCCCTATGCCAAGGAGATCATCGAGAAGCGGCTCGGCGCACCCAAGGGCTCGGTCATGAATTTCATACCG
CTGCCCGACTTCGGCGGACATCATCCGGATCCGAATCTCGTCCACGCGCGCGCTCTCTACGAGACGATGATGGCGCCTGA
TGCGCCCGATTTCGGCGCCGCGTCGGATGGCGACGGCGACCGGAATTTGATCATCGGCAAGAGCATCTTTGTCACTCCGT
CTGATAGCCTTGCAATGCTCGCAGCCAATGCGCACCTCGCCCCGGGCTATGCCAAAGGACTTGCAGGGATAGCACGCTCC
ATGCCGACGAGCGGCGCGGCTGACCGTGTGGCCGAGAAGCTCGGTATCGGCATCTACGAGACGCCGACCGGCTGGAAGTT
CTTCGGCAATCTGCTCGACGAGGGATTGGCGACGATCTGCGGGGAGGAAAGCGCCGGCACCGGATCGAACCACGTTCGCG
AAAAAGACGGCCTCTGGGCCGTGCTGCTCTGGCTCAACATCCTTGCGGCGCGCAAGGAAAGCGCGCTCGAGATCGCCCGC
AAGCACTGGGCGACCTACGGCCGGAACTACTATTCCCGCCACGACTACGAAGAGGTCGACTCCGATGCGGCGAACAGTCT
GATCACTGCGCTTCGCGACAAGCTGGCCGCGCTGCCCGGCACGAGCTTCGGCGCGCTCACGGTCGATACGGCCGACGATT
TTTCCTACCATGATCCAGTCGACAAGTCGGTCAGCAAAAACCAGGGCATCCGCATCCTTTTCAAGGGGGGATCGCGCGTC
GTCTATCGCCTGTCCGGCACGGGGACGTCGGGAGCGACACTGCGCGTCTATATCGAGCGCTACGAACCGGATCCGGCGCG
ACATGATCTCGACACGCAGGAAGCGCTCGCCGATCTGATCGCCGTTGCCGACGAGATCGCCGAGATCAAGGCACGCACCG
GCCGCGACCAACCGAGCGTCATCACCTGA

Upstream 100 bases:

>100_bases
GCCTGCAGACCCAGGGCATGAAGTCCGACGTTTCCTGGGCAAAAAGCGCGGAACGCTACGTCTCGCTTTACTCCGCTCTT
CTCGCGAAAGGCTAAGACAA

Downstream 100 bases:

>100_bases
GGTGTTGTATCAACGCCGCCCTCTGTGCGCCCTTTCCCCCTCCGCCCTGCCGGGCAGAGGGGGATCAACACCGGCACTGA
CTTGAGCTGCAATATCATGA

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MTRTVSTNPYSDQKPGTSGLRKKVPVFQQKNYAENFIQSIFDSLDGFEGQTLVIGGDGRYYNREVIQKAIKMAAANGFGR
VLVGRGGILSTPAASHVIRKYKAFGGIVLSASHNPGGPTEDFGIKYNVGNGGPAPEKVTDAIFARSKTIDSYRIVDAPDV
NLDAEGSHQVDDMTVTVIDPVADYAELMESLFDFDAIRKLIAGGFRVVFDAMSAVTGPYAKEIIEKRLGAPKGSVMNFIP
LPDFGGHHPDPNLVHARALYETMMAPDAPDFGAASDGDGDRNLIIGKSIFVTPSDSLAMLAANAHLAPGYAKGLAGIARS
MPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDEGLATICGEESAGTGSNHVREKDGLWAVLLWLNILAARKESALEIAR
KHWATYGRNYYSRHDYEEVDSDAANSLITALRDKLAALPGTSFGALTVDTADDFSYHDPVDKSVSKNQGIRILFKGGSRV
VYRLSGTGTSGATLRVYIERYEPDPARHDLDTQEALADLIAVADEIAEIKARTGRDQPSVIT

Sequences:

>Translated_542_residues
MTRTVSTNPYSDQKPGTSGLRKKVPVFQQKNYAENFIQSIFDSLDGFEGQTLVIGGDGRYYNREVIQKAIKMAAANGFGR
VLVGRGGILSTPAASHVIRKYKAFGGIVLSASHNPGGPTEDFGIKYNVGNGGPAPEKVTDAIFARSKTIDSYRIVDAPDV
NLDAEGSHQVDDMTVTVIDPVADYAELMESLFDFDAIRKLIAGGFRVVFDAMSAVTGPYAKEIIEKRLGAPKGSVMNFIP
LPDFGGHHPDPNLVHARALYETMMAPDAPDFGAASDGDGDRNLIIGKSIFVTPSDSLAMLAANAHLAPGYAKGLAGIARS
MPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDEGLATICGEESAGTGSNHVREKDGLWAVLLWLNILAARKESALEIAR
KHWATYGRNYYSRHDYEEVDSDAANSLITALRDKLAALPGTSFGALTVDTADDFSYHDPVDKSVSKNQGIRILFKGGSRV
VYRLSGTGTSGATLRVYIERYEPDPARHDLDTQEALADLIAVADEIAEIKARTGRDQPSVIT
>Mature_541_residues
TRTVSTNPYSDQKPGTSGLRKKVPVFQQKNYAENFIQSIFDSLDGFEGQTLVIGGDGRYYNREVIQKAIKMAAANGFGRV
LVGRGGILSTPAASHVIRKYKAFGGIVLSASHNPGGPTEDFGIKYNVGNGGPAPEKVTDAIFARSKTIDSYRIVDAPDVN
LDAEGSHQVDDMTVTVIDPVADYAELMESLFDFDAIRKLIAGGFRVVFDAMSAVTGPYAKEIIEKRLGAPKGSVMNFIPL
PDFGGHHPDPNLVHARALYETMMAPDAPDFGAASDGDGDRNLIIGKSIFVTPSDSLAMLAANAHLAPGYAKGLAGIARSM
PTSGAADRVAEKLGIGIYETPTGWKFFGNLLDEGLATICGEESAGTGSNHVREKDGLWAVLLWLNILAARKESALEIARK
HWATYGRNYYSRHDYEEVDSDAANSLITALRDKLAALPGTSFGALTVDTADDFSYHDPVDKSVSKNQGIRILFKGGSRVV
YRLSGTGTSGATLRVYIERYEPDPARHDLDTQEALADLIAVADEIAEIKARTGRDQPSVIT

Specific function: This enzyme participates in both the breakdown and synthesis of glucose. Required for the synthesis of capsular polysaccharide and normal lipopolysaccharide [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI21361621, Length=558, Percent_Identity=54.3010752688172, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI290463102, Length=558, Percent_Identity=54.1218637992832, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI133922562, Length=562, Percent_Identity=48.932384341637, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI290463104, Length=366, Percent_Identity=53.2786885245902, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI239741729, Length=132, Percent_Identity=50.7575757575758, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI239743670, Length=132, Percent_Identity=48.4848484848485, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786904, Length=426, Percent_Identity=27.4647887323944, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17535441, Length=560, Percent_Identity=50.7142857142857, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6323752, Length=566, Percent_Identity=47.8798586572438, Blast_Score=505, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6322722, Length=570, Percent_Identity=47.0175438596491, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17864244, Length=556, Percent_Identity=49.8201438848921, Blast_Score=544, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 58284; Mature: 58153

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTVSTNPYSDQKPGTSGLRKKVPVFQQKNYAENFIQSIFDSLDGFEGQTLVIGGDGRY
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
YNREVIQKAIKMAAANGFGRVLVGRGGILSTPAASHVIRKYKAFGGIVLSASHNPGGPTE
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
DFGIKYNVGNGGPAPEKVTDAIFARSKTIDSYRIVDAPDVNLDAEGSHQVDDMTVTVIDP
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECH
VADYAELMESLFDFDAIRKLIAGGFRVVFDAMSAVTGPYAKEIIEKRLGAPKGSVMNFIP
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEC
LPDFGGHHPDPNLVHARALYETMMAPDAPDFGAASDGDGDRNLIIGKSIFVTPSDSLAML
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECEEEECCCCCEEEE
AANAHLAPGYAKGLAGIARSMPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDEGLATIC
EECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHC
GEESAGTGSNHVREKDGLWAVLLWLNILAARKESALEIARKHWATYGRNYYSRHDYEEVD
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHH
SDAANSLITALRDKLAALPGTSFGALTVDTADDFSYHDPVDKSVSKNQGIRILFKGGSRV
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCEEEEEECCCEE
VYRLSGTGTSGATLRVYIERYEPDPARHDLDTQEALADLIAVADEIAEIKARTGRDQPSV
EEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IT
CC
>Mature Secondary Structure 
TRTVSTNPYSDQKPGTSGLRKKVPVFQQKNYAENFIQSIFDSLDGFEGQTLVIGGDGRY
CCCCCCCCCCCCCCCHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
YNREVIQKAIKMAAANGFGRVLVGRGGILSTPAASHVIRKYKAFGGIVLSASHNPGGPTE
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
DFGIKYNVGNGGPAPEKVTDAIFARSKTIDSYRIVDAPDVNLDAEGSHQVDDMTVTVIDP
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECH
VADYAELMESLFDFDAIRKLIAGGFRVVFDAMSAVTGPYAKEIIEKRLGAPKGSVMNFIP
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEC
LPDFGGHHPDPNLVHARALYETMMAPDAPDFGAASDGDGDRNLIIGKSIFVTPSDSLAML
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECEEEECCCCCEEEE
AANAHLAPGYAKGLAGIARSMPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDEGLATIC
EECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHC
GEESAGTGSNHVREKDGLWAVLLWLNILAARKESALEIARKHWATYGRNYYSRHDYEEVD
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHH
SDAANSLITALRDKLAALPGTSFGALTVDTADDFSYHDPVDKSVSKNQGIRILFKGGSRV
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCEEEEEECCCEE
VYRLSGTGTSGATLRVYIERYEPDPARHDLDTQEALADLIAVADEIAEIKARTGRDQPSV
EEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7959036; 2307661 [H]