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The map label for this gene is lysA [H]

Identifier: 150397736

GI number: 150397736

Start: 2635429

End: 2636697

Strand: Direct

Name: lysA [H]

Synonym: Smed_2538

Alternate gene names: 150397736

Gene position: 2635429-2636697 (Clockwise)

Preceding gene: 150397735

Following gene: 150397737

Centisome position: 69.69

GC content: 61.7

Gene sequence:

>1269_bases
GTGAACCATTTTCAATACCGCGACGGAATTCTTTACGCCGAAGACGTGCCTTTGACGGAAATCGCGCGTGCCGTCGGGAC
GCCGTTCTATTGTTACTCCACCGCCACGCTGGAGCGTCATTACAAGGTATTCTCGCAAGCCTTCGCCGATGTGGACGCGA
TGGTCTGCTACGCAATGAAGGCCAATTCGAACCAGGCCGTGCTGAAAACGCTTGGCCGGCTCGGCGCCGGCCTCGACGTC
GTGTCCGAGGGTGAGCTGCGCCGCGCGCTTGCAGCGGGCATTCCGCCGAGCCGGATCATGTTCTCCGGCGTCGGCAAGAC
GGCGCGCGAGATGGATTTCGCTCTGGAGGCCGGCATCTATTGCTTCAACGTCGAATCCGAGCCCGAACTGGAGGTTCTGA
ACCAAAGGGGCGTGCGCGCCGGCAAGAGGGCGCCAGTTTCCTTCCGTATCAATCCCGATGTCGATGCTCGCACCCACGCG
AAGATCTCGACCGGCAAAAAGGAGAACAAGTTCGGAATTTCCTGGGAGCGGGCACGCAGCGTCTACGCCCACGCCGCAAC
GCTTCCCGGTATCGAGGTGACCGGCATCGACATGCATATCGGCAGCCAGATCACCGAACTGCAGCCCTTCGACGACGCCT
TCAAGCTTTTGCGCGAGCTGGTCGATACTCTGCGTTCCGACGGGCATGTCATCGAACATGTCGATCTCGGCGGCGGCCTC
GGCATTCCGTACCGGGAAGATAACAACCCACCGCCGCTGCCGGACGCCTATGCAGATGTCGTCAAGAACCAGCTCAAAGG
TCTCGACTGCAAGATCGTCACCGAACCCGGCCGGCTGATCGTCGGCAATGCCGGCATCCTCGTGACCGAAGTGGTCTATG
TAAAGGACGGCGGCGACAAGACTTTCGTCATCGTGGATGGTGCGATGAACGACCTCATCCGCCCAACGCTCTATGAGGCC
TATCACGAGATTCGGCCGGTGCGGATCTCCGCAGCCAGTGCGCCGCGCATCAAAGCCGACGTCGTCGGTCCGGTCTGCGA
GACCGGCGACTATCTGGCCCTCGACCGGGAAATGGCGATGCCGAGGGCGGGCGATCTTCTCGCGATCGGCTCGGCGGGAG
CGTACGGTGCCGTTCAGGCGGGAACGTATAACAGCCGCCTGCTGGTGCCCGAGGTGCTGGTCAAGGGCGATCGTTTCCAC
GTGATCCGTCCGCGCAAGGACTATGACGAACTGATCGGCCTCGACTCGGTGCCGGACTGGCTCGATTGA

Upstream 100 bases:

>100_bases
CGATCAATACGAAAACGCCCGCCGGTACGGTCGCACCCAACGAGACTGTCGAGGACCGACCGTTCCTGCTTGACCCCCTC
CTCTGAGCCGAGGAAAGACC

Downstream 100 bases:

>100_bases
GTCGCCTGCTACTGCGGCGCCTCGCGGCGATCACGTTTTGTTGTCGTCCTCGCCTTCGCCACAAAGAATGTTATCCTGAA
GCCAGCCTCTACCGCGGCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNHFQYRDGILYAEDVPLTEIARAVGTPFYCYSTATLERHYKVFSQAFADVDAMVCYAMKANSNQAVLKTLGRLGAGLDV
VSEGELRRALAAGIPPSRIMFSGVGKTAREMDFALEAGIYCFNVESEPELEVLNQRGVRAGKRAPVSFRINPDVDARTHA
KISTGKKENKFGISWERARSVYAHAATLPGIEVTGIDMHIGSQITELQPFDDAFKLLRELVDTLRSDGHVIEHVDLGGGL
GIPYREDNNPPPLPDAYADVVKNQLKGLDCKIVTEPGRLIVGNAGILVTEVVYVKDGGDKTFVIVDGAMNDLIRPTLYEA
YHEIRPVRISAASAPRIKADVVGPVCETGDYLALDREMAMPRAGDLLAIGSAGAYGAVQAGTYNSRLLVPEVLVKGDRFH
VIRPRKDYDELIGLDSVPDWLD

Sequences:

>Translated_422_residues
MNHFQYRDGILYAEDVPLTEIARAVGTPFYCYSTATLERHYKVFSQAFADVDAMVCYAMKANSNQAVLKTLGRLGAGLDV
VSEGELRRALAAGIPPSRIMFSGVGKTAREMDFALEAGIYCFNVESEPELEVLNQRGVRAGKRAPVSFRINPDVDARTHA
KISTGKKENKFGISWERARSVYAHAATLPGIEVTGIDMHIGSQITELQPFDDAFKLLRELVDTLRSDGHVIEHVDLGGGL
GIPYREDNNPPPLPDAYADVVKNQLKGLDCKIVTEPGRLIVGNAGILVTEVVYVKDGGDKTFVIVDGAMNDLIRPTLYEA
YHEIRPVRISAASAPRIKADVVGPVCETGDYLALDREMAMPRAGDLLAIGSAGAYGAVQAGTYNSRLLVPEVLVKGDRFH
VIRPRKDYDELIGLDSVPDWLD
>Mature_422_residues
MNHFQYRDGILYAEDVPLTEIARAVGTPFYCYSTATLERHYKVFSQAFADVDAMVCYAMKANSNQAVLKTLGRLGAGLDV
VSEGELRRALAAGIPPSRIMFSGVGKTAREMDFALEAGIYCFNVESEPELEVLNQRGVRAGKRAPVSFRINPDVDARTHA
KISTGKKENKFGISWERARSVYAHAATLPGIEVTGIDMHIGSQITELQPFDDAFKLLRELVDTLRSDGHVIEHVDLGGGL
GIPYREDNNPPPLPDAYADVVKNQLKGLDCKIVTEPGRLIVGNAGILVTEVVYVKDGGDKTFVIVDGAMNDLIRPTLYEA
YHEIRPVRISAASAPRIKADVVGPVCETGDYLALDREMAMPRAGDLLAIGSAGAYGAVQAGTYNSRLLVPEVLVKGDRFH
VIRPRKDYDELIGLDSVPDWLD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=353, Percent_Identity=25.4957507082153, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI22538418, Length=335, Percent_Identity=24.4776119402985, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI21361583, Length=335, Percent_Identity=24.4776119402985, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI16506287, Length=346, Percent_Identity=24.5664739884393, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=30.2107728337237, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=343, Percent_Identity=22.1574344023324, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586472, Length=379, Percent_Identity=25.065963060686, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24586474, Length=368, Percent_Identity=27.445652173913, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46121; Mature: 46121

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFQYRDGILYAEDVPLTEIARAVGTPFYCYSTATLERHYKVFSQAFADVDAMVCYAMK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEE
ANSNQAVLKTLGRLGAGLDVVSEGELRRALAAGIPPSRIMFSGVGKTAREMDFALEAGIY
CCCCHHHHHHHHHHCCCCCEECCHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHCCEE
CFNVESEPELEVLNQRGVRAGKRAPVSFRINPDVDARTHAKISTGKKENKFGISWERARS
EEECCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCHHHHHH
VYAHAATLPGIEVTGIDMHIGSQITELQPFDDAFKLLRELVDTLRSDGHVIEHVDLGGGL
HHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYREDNNPPPLPDAYADVVKNQLKGLDCKIVTEPGRLIVGNAGILVTEVVYVKDGGDK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCE
TFVIVDGAMNDLIRPTLYEAYHEIRPVRISAASAPRIKADVVGPVCETGDYLALDREMAM
EEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHCCCCHHCCCCEEEECHHHCC
PRAGDLLAIGSAGAYGAVQAGTYNSRLLVPEVLVKGDRFHVIRPRKDYDELIGLDSVPDW
CCCCCEEEECCCCCCCEEECCCCCCEEEHHHHHHCCCEEEEECCCCCHHHHCCCCCCCCC
LD
CC
>Mature Secondary Structure
MNHFQYRDGILYAEDVPLTEIARAVGTPFYCYSTATLERHYKVFSQAFADVDAMVCYAMK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEE
ANSNQAVLKTLGRLGAGLDVVSEGELRRALAAGIPPSRIMFSGVGKTAREMDFALEAGIY
CCCCHHHHHHHHHHCCCCCEECCHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHCCEE
CFNVESEPELEVLNQRGVRAGKRAPVSFRINPDVDARTHAKISTGKKENKFGISWERARS
EEECCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCHHHHHH
VYAHAATLPGIEVTGIDMHIGSQITELQPFDDAFKLLRELVDTLRSDGHVIEHVDLGGGL
HHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYREDNNPPPLPDAYADVVKNQLKGLDCKIVTEPGRLIVGNAGILVTEVVYVKDGGDK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCE
TFVIVDGAMNDLIRPTLYEAYHEIRPVRISAASAPRIKADVVGPVCETGDYLALDREMAM
EEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHCCCCHHCCCCEEEECHHHCC
PRAGDLLAIGSAGAYGAVQAGTYNSRLLVPEVLVKGDRFHVIRPRKDYDELIGLDSVPDW
CCCCCEEEECCCCCCCEEECCCCCCEEEHHHHHHCCCEEEEECCCCCHHHHCCCCCCCCC
LD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]