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The map label for this gene is tlpA [H]

Identifier: 150397733

GI number: 150397733

Start: 2632897

End: 2633571

Strand: Reverse

Name: tlpA [H]

Synonym: Smed_2535

Alternate gene names: 150397733

Gene position: 2633571-2632897 (Counterclockwise)

Preceding gene: 150397738

Following gene: 150397725

Centisome position: 69.64

GC content: 65.19

Gene sequence:

>675_bases
ATGCCAGACCAGAAGAAACGCCCTCCAGCCCGGAAATTGTTCGCGATCGCTGCCCTTCTTGGGGTGATCGCCGGTGCGGC
TGCGGTATACGTGAAGGAGACGGGGTCTGGCAATGGCGGCGACGCGCCGACGGCCGATGCGAGCTGCCCGCTTGCGGCGC
AAAAGGTTGCTTCGCTCACGCCGCTGATGCGTGGTCAGGTCGCGGCGATGACTCCGGCGGCCAACGCGCGGCCGATCGGC
GGCCTCGACTTCGCCGGCCCGGACGGCAAGCCGCTGACGCTCGCTGCCTTTGCAGGCAAGACCGTTCTCGTCAATCTCTG
GGCGACCTGGTGCGTGCCCTGCCGTGAGGAAATGCCGGCGCTCAACGCCCTGCAACAGGCGCTCGGCGGCGATCGTTTCG
AAGTGGTCGCGATCAATATCGACACCGGTGCCGACGACAAGCCGAAGGCTTTTCTCGACGAGGTCGGCGTTCAAGCACTC
GGCTACTACCGCGACGCCTCGATGGGCGTTTTCAACACGCTCAAGAAGGAGGGGCTCGCCTTTGGGCTTCCCGCGACCTT
GCTGCTCGACGAAAAGGGTTGCCTGATCGGCTCGATGAATGGACCTGCCGCCTGGGACAGCGACGATGCAAAGAAGCTGA
TCGAGGCGGCGATGGCTCCGCCCGCGGCGAGTTGA

Upstream 100 bases:

>100_bases
GGAAGCGGGCCCCGAGGCGAAGCGACCGCCCCACATCTGGTTGGAGGATTTCGTCTCGGAACTGCCGTCAGCCATCAGGA
TGCCCGCCTTGGAGAATGAA

Downstream 100 bases:

>100_bases
AGACGCAGGCGGGTTTTCGCCGTTGCTGAAGAAAGGTTCAGCGTGTCGGTACGGGAGCCTCGCCCCGATAGTCGTAGAAG
CCGCGGCCGGACTTGCGGCC

Product: redoxin domain-containing protein

Products: NA

Alternate protein names: Cytochrome c biogenesis protein tlpA [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MPDQKKRPPARKLFAIAALLGVIAGAAAVYVKETGSGNGGDAPTADASCPLAAQKVASLTPLMRGQVAAMTPAANARPIG
GLDFAGPDGKPLTLAAFAGKTVLVNLWATWCVPCREEMPALNALQQALGGDRFEVVAINIDTGADDKPKAFLDEVGVQAL
GYYRDASMGVFNTLKKEGLAFGLPATLLLDEKGCLIGSMNGPAAWDSDDAKKLIEAAMAPPAAS

Sequences:

>Translated_224_residues
MPDQKKRPPARKLFAIAALLGVIAGAAAVYVKETGSGNGGDAPTADASCPLAAQKVASLTPLMRGQVAAMTPAANARPIG
GLDFAGPDGKPLTLAAFAGKTVLVNLWATWCVPCREEMPALNALQQALGGDRFEVVAINIDTGADDKPKAFLDEVGVQAL
GYYRDASMGVFNTLKKEGLAFGLPATLLLDEKGCLIGSMNGPAAWDSDDAKKLIEAAMAPPAAS
>Mature_223_residues
PDQKKRPPARKLFAIAALLGVIAGAAAVYVKETGSGNGGDAPTADASCPLAAQKVASLTPLMRGQVAAMTPAANARPIGG
LDFAGPDGKPLTLAAFAGKTVLVNLWATWCVPCREEMPALNALQQALGGDRFEVVAINIDTGADDKPKAFLDEVGVQALG
YYRDASMGVFNTLKKEGLAFGLPATLLLDEKGCLIGSMNGPAAWDSDDAKKLIEAAMAPPAAS

Specific function: Involved in cytochrome aa3 assembly [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013740
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: NA

Molecular weight: Translated: 23008; Mature: 22877

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQKKRPPARKLFAIAALLGVIAGAAAVYVKETGSGNGGDAPTADASCPLAAQKVASLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
PLMRGQVAAMTPAANARPIGGLDFAGPDGKPLTLAAFAGKTVLVNLWATWCVPCREEMPA
HHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHCCCCHHCCHH
LNALQQALGGDRFEVVAINIDTGADDKPKAFLDEVGVQALGYYRDASMGVFNTLKKEGLA
HHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
FGLPATLLLDEKGCLIGSMNGPAAWDSDDAKKLIEAAMAPPAAS
ECCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PDQKKRPPARKLFAIAALLGVIAGAAAVYVKETGSGNGGDAPTADASCPLAAQKVASLT
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
PLMRGQVAAMTPAANARPIGGLDFAGPDGKPLTLAAFAGKTVLVNLWATWCVPCREEMPA
HHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHCCCCHHCCHH
LNALQQALGGDRFEVVAINIDTGADDKPKAFLDEVGVQALGYYRDASMGVFNTLKKEGLA
HHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
FGLPATLLLDEKGCLIGSMNGPAAWDSDDAKKLIEAAMAPPAAS
ECCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8253065; 12597275 [H]