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The map label for this gene is clpP3 [H]

Identifier: 150397489

GI number: 150397489

Start: 2365456

End: 2366043

Strand: Reverse

Name: clpP3 [H]

Synonym: Smed_2289

Alternate gene names: 150397489

Gene position: 2366043-2365456 (Counterclockwise)

Preceding gene: 150397492

Following gene: 150397488

Centisome position: 62.56

GC content: 59.18

Gene sequence:

>588_bases
ATGCGGAACGACGACGATCAGGAAGAAAAGAAGACCGAATTGCCCTTGGGCAAGGAAACGGAGGCGAACCTTTTCAAGTC
GCGTTCGATTTTCATTTACGGGAACATCACCCAGGAACTCGCGCAGAAGGTCTGCTCGCAGCTCGTGGCTCTCGCCGCGG
CCAGCGATGACGACATCCGCATCTTCGTCAACTCGCCCGGCGGCCATGTCGAATCGGGCGACAGCATCCACGACATGATC
AAGTTCGTGAAGCCGAAGGTCTGGACGATCGGTACCGGATGGGTCGCTTCCGCTGGCGCACTCATCTATGTCGCCGCCCC
CAAGGAACAGCGGCTGTGCCTGCCGAATACCCGCTTCCTTTTGCACCAACCGTCGGGCGGCACACGTGGCATGGCCTCCG
ATATCGAGATTCAGGCGCGCGAAATCATCAAGATGAACGAGCGTCTGAACCGGATCTTCTCCGAAGCGACCGGTCAGCCC
GTCGAGAAAATCGCCAAGGACACCGATCGCGACTACTGGCTCGGTGCGGAAGAGGCGAAGGCGTATGGGCTCGTCTCGCG
CATCGTCACCTCCATCGCGGAAATCTAA

Upstream 100 bases:

>100_bases
CAAAGCCGGCGGTACGAACCGTGTTCGGGCGACGGCCTGCATTGTTTTCATCGTCGAGTCGCATTATCTCACTGGAGAGA
TTTCACGAGGAGTCGGAAGA

Downstream 100 bases:

>100_bases
AGCGTCCGCTCCTCAACGGCCGCCGCCCCCTTCTTCCCGGTTGCGGGGAGAAGGGGGCGGCGGCGCGCCGATACCCTCTG
CCCGCACTCTTGCTCCGCTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 3 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGNITQELAQKVCSQLVALAAASDDDIRIFVNSPGGHVESGDSIHDMI
KFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQP
VEKIAKDTDRDYWLGAEEAKAYGLVSRIVTSIAEI

Sequences:

>Translated_195_residues
MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGNITQELAQKVCSQLVALAAASDDDIRIFVNSPGGHVESGDSIHDMI
KFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQP
VEKIAKDTDRDYWLGAEEAKAYGLVSRIVTSIAEI
>Mature_195_residues
MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGNITQELAQKVCSQLVALAAASDDDIRIFVNSPGGHVESGDSIHDMI
KFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFLLHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQP
VEKIAKDTDRDYWLGAEEAKAYGLVSRIVTSIAEI

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=170, Percent_Identity=34.7058823529412, Blast_Score=120, Evalue=7e-28,
Organism=Escherichia coli, GI1786641, Length=170, Percent_Identity=45.2941176470588, Blast_Score=163, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17538017, Length=170, Percent_Identity=37.6470588235294, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129427, Length=169, Percent_Identity=36.6863905325444, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21594; Mature: 21594

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGNITQELAQKVCSQLVALAAASDDDIR
CCCCCCHHHHHHCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCEE
IFVNSPGGHVESGDSIHDMIKFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFL
EEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCHHHCCCEEEEEECCCCCCEECCCCEEE
LHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQPVEKIAKDTDRDYWLGAEEAK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEECCHHHHH
AYGLVSRIVTSIAEI
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRNDDDQEEKKTELPLGKETEANLFKSRSIFIYGNITQELAQKVCSQLVALAAASDDDIR
CCCCCCHHHHHHCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCEE
IFVNSPGGHVESGDSIHDMIKFVKPKVWTIGTGWVASAGALIYVAAPKEQRLCLPNTRFL
EEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCHHHCCCEEEEEECCCCCCEECCCCEEE
LHQPSGGTRGMASDIEIQAREIIKMNERLNRIFSEATGQPVEKIAKDTDRDYWLGAEEAK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEECCHHHHH
AYGLVSRIVTSIAEI
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]