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The map label for this gene is gltC [H]

Identifier: 150397298

GI number: 150397298

Start: 2157638

End: 2158558

Strand: Direct

Name: gltC [H]

Synonym: Smed_2097

Alternate gene names: 150397298

Gene position: 2157638-2158558 (Clockwise)

Preceding gene: 150397280

Following gene: 150397299

Centisome position: 57.05

GC content: 60.48

Gene sequence:

>921_bases
ATGGATCTTTCTCGCTTGCGTGCTCTACGGGAATTGTCGATCCGCAAGACCATGGCGGCGGTAGCCGAGGCGCTCTACGT
CTCGCCATCGGCTGTTTCGCAGCAGATCGCCCTGCTCGAACAGGAGGTCGGTATCGACCTGATCGAGCGCCGCGGCCGCG
GCGTCGAACTGACGCCCGCCGGAAAGCAGCTCGTCGAACGGGCAGAGCGAATCCTGATAGAACTGGAGTCGGCGCGAGCC
GATATTGCGGAGTTAAAGAAGGTCATTGCGGGTGAATTGCGCGTAGCGGCCTTTCCGTCCGTAGCCGGAGCAGTCGTTGC
GGGCGCAATCCATGGGCTGCATCGTCTCCATCCCCGGCTGACGGTTCAGTTCGATGAAATGGAGCCGGCCGAGAGCCTCG
CCGCGCTTCGCAGCTGGCAGACGGATATCGCGATCATCGACGATCTCAATGTACCGTCCGGCGCGCTCGACCCGAACATC
GAGACGATTCCGCTCATGGAAGACGTCTTCAATGTGATGGTTTCCAGAACGCATCCCCTGGCAGAGCAATCCACGGTCAT
GCTGCACCAATTGCGTAACGAACGCTGGGCTCTCGACACCGCATCCTCGACCTACAACCGCATGATCACCGATGCCTGCC
AGGAGGCAGGCTTCACCCCGAACATCGTCGCCCGCTGCAAGGGCTTCGAGGTTACGATCGCGCTGATAAGGCAAGGCTAT
GGCATTTCTATCCTTCCGGGCCTGAGGGCAAGCTATGACCTCGAAGACGTCTGGGTATGCAAGCTTGAGCCGGAGATCCG
TCGCAAGATTTCCCTCGCGTTCCGTAAAGGAGAGAAACGCAGCCCCGCCGTTCAGGCGTTCATTGCGGAAGTGAACGAAC
GCGTCGGCTCCCGCCGCCGCGTGCCTGCCGGAGAAAGATAA

Upstream 100 bases:

>100_bases
AGGAAGGCTAGCGGCCGCATCGATCCAGAAAAAGTTAATAATATTTGCACATATGTTCTGATCTGCTAATGATTTGAGGG
GCTGATTTCAGGAGTGGACG

Downstream 100 bases:

>100_bases
CAGCCGGGACGCGCGAAGGCCCTCCCATTAAAATCAAACAGTTTTTCTAAATAGTACATAAAGAAAAATTAAGTAGACCT
GAATGAACTGCCTTCCTATC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MDLSRLRALRELSIRKTMAAVAEALYVSPSAVSQQIALLEQEVGIDLIERRGRGVELTPAGKQLVERAERILIELESARA
DIAELKKVIAGELRVAAFPSVAGAVVAGAIHGLHRLHPRLTVQFDEMEPAESLAALRSWQTDIAIIDDLNVPSGALDPNI
ETIPLMEDVFNVMVSRTHPLAEQSTVMLHQLRNERWALDTASSTYNRMITDACQEAGFTPNIVARCKGFEVTIALIRQGY
GISILPGLRASYDLEDVWVCKLEPEIRRKISLAFRKGEKRSPAVQAFIAEVNERVGSRRRVPAGER

Sequences:

>Translated_306_residues
MDLSRLRALRELSIRKTMAAVAEALYVSPSAVSQQIALLEQEVGIDLIERRGRGVELTPAGKQLVERAERILIELESARA
DIAELKKVIAGELRVAAFPSVAGAVVAGAIHGLHRLHPRLTVQFDEMEPAESLAALRSWQTDIAIIDDLNVPSGALDPNI
ETIPLMEDVFNVMVSRTHPLAEQSTVMLHQLRNERWALDTASSTYNRMITDACQEAGFTPNIVARCKGFEVTIALIRQGY
GISILPGLRASYDLEDVWVCKLEPEIRRKISLAFRKGEKRSPAVQAFIAEVNERVGSRRRVPAGER
>Mature_306_residues
MDLSRLRALRELSIRKTMAAVAEALYVSPSAVSQQIALLEQEVGIDLIERRGRGVELTPAGKQLVERAERILIELESARA
DIAELKKVIAGELRVAAFPSVAGAVVAGAIHGLHRLHPRLTVQFDEMEPAESLAALRSWQTDIAIIDDLNVPSGALDPNI
ETIPLMEDVFNVMVSRTHPLAEQSTVMLHQLRNERWALDTASSTYNRMITDACQEAGFTPNIVARCKGFEVTIALIRQGY
GISILPGLRASYDLEDVWVCKLEPEIRRKISLAFRKGEKRSPAVQAFIAEVNERVGSRRRVPAGER

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=270, Percent_Identity=28.5185185185185, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790399, Length=280, Percent_Identity=25.7142857142857, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787601, Length=246, Percent_Identity=24.7967479674797, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693105, Length=294, Percent_Identity=25.1700680272109, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=29.4520547945205, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=286, Percent_Identity=27.6223776223776, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=24, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI2367136, Length=292, Percent_Identity=24.3150684931507, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789506, Length=243, Percent_Identity=25.1028806584362, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=293, Percent_Identity=23.8907849829352, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788887, Length=303, Percent_Identity=25.0825082508251, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788296, Length=249, Percent_Identity=27.3092369477912, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081978, Length=123, Percent_Identity=36.5853658536585, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33862; Mature: 33862

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSRLRALRELSIRKTMAAVAEALYVSPSAVSQQIALLEQEVGIDLIERRGRGVELTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCCCCEEECCC
GKQLVERAERILIELESARADIAELKKVIAGELRVAAFPSVAGAVVAGAIHGLHRLHPRL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCE
TVQFDEMEPAESLAALRSWQTDIAIIDDLNVPSGALDPNIETIPLMEDVFNVMVSRTHPL
EEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCC
AEQSTVMLHQLRNERWALDTASSTYNRMITDACQEAGFTPNIVARCKGFEVTIALIRQGY
HHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEHHHHHCCC
GISILPGLRASYDLEDVWVCKLEPEIRRKISLAFRKGEKRSPAVQAFIAEVNERVGSRRR
CEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
VPAGER
CCCCCC
>Mature Secondary Structure
MDLSRLRALRELSIRKTMAAVAEALYVSPSAVSQQIALLEQEVGIDLIERRGRGVELTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCCCCEEECCC
GKQLVERAERILIELESARADIAELKKVIAGELRVAAFPSVAGAVVAGAIHGLHRLHPRL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCE
TVQFDEMEPAESLAALRSWQTDIAIIDDLNVPSGALDPNIETIPLMEDVFNVMVSRTHPL
EEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCC
AEQSTVMLHQLRNERWALDTASSTYNRMITDACQEAGFTPNIVARCKGFEVTIALIRQGY
HHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEHHHHHCCC
GISILPGLRASYDLEDVWVCKLEPEIRRKISLAFRKGEKRSPAVQAFIAEVNERVGSRRR
CEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
VPAGER
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]