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The map label for this gene is murC [H]

Identifier: 150397282

GI number: 150397282

Start: 2137416

End: 2138831

Strand: Reverse

Name: murC [H]

Synonym: Smed_2081

Alternate gene names: 150397282

Gene position: 2138831-2137416 (Counterclockwise)

Preceding gene: 150397283

Following gene: 150397281

Centisome position: 56.55

GC content: 60.88

Gene sequence:

>1416_bases
ATGAAGATGCCGAAGACGATCGGGCTCGTACATTTCATTGGTATCGGCGGCATCGGCATGAGCGGTATTGCCGAGGTGCT
GCACAATCTCGGCCATCGCGTCCAGGGTTCCGACCAGGCGGAAAGCGCCAATGTGCAGCGCCTGAGGGAAAAGGGCATCA
GAATTTCCATCGGTCACAAGGCGGAAAATCTTGGCGATGCCGAGGTGATCGTGGTCTCGACCGCGATCAAGAAGGACAAT
CCAGAGCTCATCGCTGCGCGTGAAAAGTTTCTGCCGGTCGTCCGGCGCGCCGAGATGCTGGCCGAGCTGATGCGTTTCCG
AAATGCGATTGCAATCGGCGGAACGCACGGAAAGACCACCACGACCTCGATGGTGGCCGCATTGCTCGATGCAGGTGGCC
TCGACCCGACGGTGATCAACGGCGGTATCATCAATGCCTACGGCACCAATGCACGCATGGGCGCGGGCGAATGGATGGTC
GTTGAAGCCGACGAATCCGACGGCACGTTCCTGAAGCTGCCCGCCGACATCGCAGTGGTCACCAATATCGATCCCGAGCA
TCTCGACCATTACGGCAGCTTCGACGCCGTGCGCTCGGCCTTTCGCCAGTTCGTCGAAAATGTGCCGTTTTACGGCTTTG
GTGTGCTGTGTCTCGATCATCCGGAAGTCCAGTCCATGGTGGGAAAGATCGAGGACCGGAAAGTCGTCACCTATGGCGAA
AACCCGCAGGCGGACGTGCGCTTCCACAATATCCGGATGGACGGTGCCACCTCGATCTTCGATATCGAGATACGCCGCCG
CCGCACGGGTCAGGTGATCGAGATCAAGGATCTCAGGCTGCCGATGCCCGGCCGTCACAATGTGTCGAACGCCACGGCCG
CCGTGGCGGTCGCGCAGCGGCTCGGCATCAAGCCGGAGGATATTGCAAGAGGGATCGCCTCCTTCGGCGGCGTCAAACGC
CGATTCACGTTGACGGGCGAGTGGAACGGCGCGCGCATCTTCGACGACTACGGTCATCATCCGGTCGAAATCAAAGCCGT
CCTGAGGGCCGCGCGGGAGGCCTGTCAGGGGCGCATCGTCGCGGTCCACCAGCCGCATCGCTATTCGCGCCTGTCGAGCC
TCTTCGAGGATTTCACATCCTGCTTCAACGACGCCGACACGATTCTGCTCGCTCCGGTCTATTCGGCCGGCGAAGAAGCG
ATAGATGGAGTCAATTCGGAAGCGCTGGTCAACCGCATCAAGGCTGCCGGCCACCGCGATGCCCGCCATATCTCGGGACA
GGAGGCCCTTGCGCCTGTTGTCGCCAAGATTGCGCAGCCGGGCGATTTTGTGGTTCTCTTGGGGGCTGGCAGCATTACCT
ATTGGGCCGCGGCGCTGCCGAAGCAGCTCGCGGAAATCTCGGGAAATCGAGCATGA

Upstream 100 bases:

>100_bases
CCCGCCAGACCGGCAAGGCGGGTGCCGCGCGCTTGCTTGCGTTACTGGTAGAGGCTATTGCCAGCGGCTCGACAGTCGCG
AAGTTCAAGGAAACACGTTC

Downstream 100 bases:

>100_bases
AACAGGTCAACGGGCAGAAACTCCTCGAATCGCTCGGAAACGGCGTCAGCGCGATACGCGGGCGTATCACGCCCGATGCC
CCAATGGACCGCGTTACCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKMPKTIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLREKGIRISIGHKAENLGDAEVIVVSTAIKKDN
PELIAAREKFLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDAVRSAFRQFVENVPFYGFGVLCLDHPEVQSMVGKIEDRKVVTYGE
NPQADVRFHNIRMDGATSIFDIEIRRRRTGQVIEIKDLRLPMPGRHNVSNATAAVAVAQRLGIKPEDIARGIASFGGVKR
RFTLTGEWNGARIFDDYGHHPVEIKAVLRAAREACQGRIVAVHQPHRYSRLSSLFEDFTSCFNDADTILLAPVYSAGEEA
IDGVNSEALVNRIKAAGHRDARHISGQEALAPVVAKIAQPGDFVVLLGAGSITYWAAALPKQLAEISGNRA

Sequences:

>Translated_471_residues
MKMPKTIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLREKGIRISIGHKAENLGDAEVIVVSTAIKKDN
PELIAAREKFLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDAVRSAFRQFVENVPFYGFGVLCLDHPEVQSMVGKIEDRKVVTYGE
NPQADVRFHNIRMDGATSIFDIEIRRRRTGQVIEIKDLRLPMPGRHNVSNATAAVAVAQRLGIKPEDIARGIASFGGVKR
RFTLTGEWNGARIFDDYGHHPVEIKAVLRAAREACQGRIVAVHQPHRYSRLSSLFEDFTSCFNDADTILLAPVYSAGEEA
IDGVNSEALVNRIKAAGHRDARHISGQEALAPVVAKIAQPGDFVVLLGAGSITYWAAALPKQLAEISGNRA
>Mature_471_residues
MKMPKTIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLREKGIRISIGHKAENLGDAEVIVVSTAIKKDN
PELIAAREKFLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDAVRSAFRQFVENVPFYGFGVLCLDHPEVQSMVGKIEDRKVVTYGE
NPQADVRFHNIRMDGATSIFDIEIRRRRTGQVIEIKDLRLPMPGRHNVSNATAAVAVAQRLGIKPEDIARGIASFGGVKR
RFTLTGEWNGARIFDDYGHHPVEIKAVLRAAREACQGRIVAVHQPHRYSRLSSLFEDFTSCFNDADTILLAPVYSAGEEA
IDGVNSEALVNRIKAAGHRDARHISGQEALAPVVAKIAQPGDFVVLLGAGSITYWAAALPKQLAEISGNRA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=469, Percent_Identity=43.7100213219616, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1790680, Length=459, Percent_Identity=28.9760348583878, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51000; Mature: 51000

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPKTIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLREKGIRISIGHK
CCCCCHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCC
AENLGDAEVIVVSTAIKKDNPELIAAREKFLPVVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSMVAALLDAGGLDPTVINGGIINAYGTNARMGAGEWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDAVRSAFRQFVENVPFYGFGVLCLDHPEVQSMVGKIEDRKVVTYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEECC
NPQADVRFHNIRMDGATSIFDIEIRRRRTGQVIEIKDLRLPMPGRHNVSNATAAVAVAQR
CCCCCEEEEEEEECCCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LGIKPEDIARGIASFGGVKRRFTLTGEWNGARIFDDYGHHPVEIKAVLRAAREACQGRIV
HCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRYSRLSSLFEDFTSCFNDADTILLAPVYSAGEEAIDGVNSEALVNRIKAAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCHHHHCCCCHHHHHHHHHHCCCCC
ARHISGQEALAPVVAKIAQPGDFVVLLGAGSITYWAAALPKQLAEISGNRA
HHHCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKMPKTIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQAESANVQRLREKGIRISIGHK
CCCCCHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCC
AENLGDAEVIVVSTAIKKDNPELIAAREKFLPVVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSMVAALLDAGGLDPTVINGGIINAYGTNARMGAGEWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDAVRSAFRQFVENVPFYGFGVLCLDHPEVQSMVGKIEDRKVVTYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEECC
NPQADVRFHNIRMDGATSIFDIEIRRRRTGQVIEIKDLRLPMPGRHNVSNATAAVAVAQR
CCCCCEEEEEEEECCCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LGIKPEDIARGIASFGGVKRRFTLTGEWNGARIFDDYGHHPVEIKAVLRAAREACQGRIV
HCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRYSRLSSLFEDFTSCFNDADTILLAPVYSAGEEAIDGVNSEALVNRIKAAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCHHHHCCCCHHHHHHHHHHCCCCC
ARHISGQEALAPVVAKIAQPGDFVVLLGAGSITYWAAALPKQLAEISGNRA
HHHCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]