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The map label for this gene is aqpZ1 [H]

Identifier: 150397279

GI number: 150397279

Start: 2133977

End: 2134663

Strand: Reverse

Name: aqpZ1 [H]

Synonym: Smed_2078

Alternate gene names: 150397279

Gene position: 2134663-2133977 (Counterclockwise)

Preceding gene: 150397281

Following gene: 150397278

Centisome position: 56.44

GC content: 64.05

Gene sequence:

>687_bases
ATGTTCAGGAAGCTTTCTGTGGAATTTCTCGGTACTTTCTGGCTCGTTCTCGGCGGGTGCGGCAGCGCCGTGCTTGCCGC
GGCCTTCCCGGAGGTCGGTATCGGCCTGCTTGGCGTCTCCTTTGCCTTCGGCCTTACGGTGCTGACCATGGCCTATGCGG
TTGGCGGAATTTCCGGCGGCCATTTCAATCCGGCGGTATCGCTCGGTCTTGCCGTCGTCGGCAGGGTGCCGCCGGCGAGC
CTCGTCGGATACATCATCGCGCAGGTTGCCGGGGCGATCGCCGCGGCTGCCGTCCTCTACGTGATCGCCACCGGCAAGGC
CGATTTCCAGCTTGGTAGTTTTGCCGCCAATGGCTACGGCGAGCACTCTCCGGGCGGCTACTCGCTGACGGCAGCGCTCG
TCACCGAGGTGGTCATGACCGCCTTTTTCCTGTTCATCATTCTGGGCTCGACGCACAGCCGGGTGCCTGTGGGCTTCGCA
CCCATCGCCATCGGCCTCGGGCTGACGCTGATTCACCTCGTGTCGATCCCGGTCACCAACACCTCGGTCAATCCGGCTCG
ATCGACCGGGCAGGCGCTGTTCGTCGGCGATTGGGCGATTTCACAGCTCTGGCTTTTCTGGGTGGCGCCGCTGATCGGTG
CGGTCATTGCCGGAATCGCCTGGAAGGTCGTCGGCGAGGAAGCCTAG

Upstream 100 bases:

>100_bases
TTGCGGGCAAGAAGGGTGAATACATCTCCCGCTTGACGGGATTCGAATACTGTAGAACTCTCGTTAACGAAGCGTTTTGC
TTCGTTTTGGGGGAGTATTC

Downstream 100 bases:

>100_bases
CCGGAAAAAGGCATGGAACACCCGGCCAAGACCTCCACGAGCCCGCCTGCGCCCGCAGGCGGGCTCGTCCTTTCCAGAGA
TTATTTCCCTTGCAAGCCAC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGGHFNPAVSLGLAVVGRVPPAS
LVGYIIAQVAGAIAAAAVLYVIATGKADFQLGSFAANGYGEHSPGGYSLTAALVTEVVMTAFFLFIILGSTHSRVPVGFA
PIAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIAWKVVGEEA

Sequences:

>Translated_228_residues
MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGGHFNPAVSLGLAVVGRVPPAS
LVGYIIAQVAGAIAAAAVLYVIATGKADFQLGSFAANGYGEHSPGGYSLTAALVTEVVMTAFFLFIILGSTHSRVPVGFA
PIAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIAWKVVGEEA
>Mature_228_residues
MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGGHFNPAVSLGLAVVGRVPPAS
LVGYIIAQVAGAIAAAAVLYVIATGKADFQLGSFAANGYGEHSPGGYSLTAALVTEVVMTAFFLFIILGSTHSRVPVGFA
PIAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIAWKVVGEEA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=216, Percent_Identity=39.3518518518519, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI37694062, Length=225, Percent_Identity=37.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4755125, Length=222, Percent_Identity=34.2342342342342, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502181, Length=222, Percent_Identity=34.2342342342342, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502179, Length=224, Percent_Identity=33.9285714285714, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI6912506, Length=213, Percent_Identity=32.8638497652582, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI157266307, Length=239, Percent_Identity=33.4728033472803, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=32.7354260089686, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22538420, Length=247, Percent_Identity=29.9595141700405, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI45446752, Length=202, Percent_Identity=29.2079207920792, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4826645, Length=238, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=68.4210526315789, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1790362, Length=246, Percent_Identity=28.8617886178862, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993722, Length=230, Percent_Identity=33.4782608695652, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17558372, Length=234, Percent_Identity=29.4871794871795, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=233, Percent_Identity=29.1845493562232, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=233, Percent_Identity=29.1845493562232, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325450, Length=228, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24652747, Length=228, Percent_Identity=35.5263157894737, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45551084, Length=228, Percent_Identity=35.5263157894737, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17136672, Length=230, Percent_Identity=29.5652173913043, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24652751, Length=223, Percent_Identity=32.7354260089686, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922038, Length=223, Percent_Identity=32.7354260089686, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550503, Length=226, Percent_Identity=25.2212389380531, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23205; Mature: 23205

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLAVVGRVPPASLVGYIIAQVAGAIAAAAVLYVIATGKADFQLGSFAANGYG
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEECCCCC
EHSPGGYSLTAALVTEVVMTAFFLFIILGSTHSRVPVGFAPIAIGLGLTLIHLVSIPVTN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIAWKVVGEEA
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFRKLSVEFLGTFWLVLGGCGSAVLAAAFPEVGIGLLGVSFAFGLTVLTMAYAVGGISGG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLAVVGRVPPASLVGYIIAQVAGAIAAAAVLYVIATGKADFQLGSFAANGYG
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEECCCCC
EHSPGGYSLTAALVTEVVMTAFFLFIILGSTHSRVPVGFAPIAIGLGLTLIHLVSIPVTN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGDWAISQLWLFWVAPLIGAVIAGIAWKVVGEEA
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]