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The map label for this gene is lpxC [H]

Identifier: 150397274

GI number: 150397274

Start: 2127249

End: 2128202

Strand: Reverse

Name: lpxC [H]

Synonym: Smed_2073

Alternate gene names: 150397274

Gene position: 2128202-2127249 (Counterclockwise)

Preceding gene: 150397275

Following gene: 150397273

Centisome position: 56.27

GC content: 59.96

Gene sequence:

>954_bases
ATGGGAATCGAACTGCTCGGGTTTCAGACAACGATTGCAAACCCGATAACCCTCAAGGGTATTGGCGTTCACTCCGGGTC
GGAAGTCGAGATTACCTTCCACCCGGCTGATGCCGATGCCGGCATTGTTTTCCAGCGGGTGCTCGCTGGCGGGCGGCTCA
GCGAGTTCCGGGCCGTCTCGTCGCATGTCGGCAATACCGATCTCTGCACCGTTCTAGGTCTGTCGCCCTCGACGTCGATC
GCGACGATCGAGCATGTCATGGCAGCGGTCTATGCACTCGGCCTCGACAACCTGCTGATCGAAGTACATGGCGCCGAAAT
GCCGATCATGGATGGCAGCTCCGCGCCCTTCATCGAAGCGATCGAGCAGGCAGGCGTTCACTCGCTCCCGGAGAAGCGCC
GCTATATCCGTATACTCAAGCCGGTGCGCATCGAATCGGGTGCATCCTGGTCCGAGTTCACGCCCTATGACGGCATGCGC
TTTGAAGTCGAGATCGATTTCGATTGCCCGCTCATCGGCCGGCAATCCTGGAAAGGCGATATGACACCGTCGGTTTTCAA
GCGGGAATTGTCGCGGGCGCGTACTTTCGGTTTCATGCGGGATGTGGAGCGACTTTGGGCCGGGGGGTTCGCACTCGGCT
CGTCGCTCGAGAATTCCGTGGTGATCTCGGATGACAATACGGTCATCAATGTCGAGGGTCTGCGTTATACGGACGAGTTC
GTTCGCCACAAAACGCTTGATGCCGTAGGCGATCTTTCTTTGGCGGGTGCGCCCTTCCTTGGCTGTTACCGCTCCTATCG
CGGCGGGCACCGGATGAATGCCAATGCCCTAAAGGCATTGCTCAGCGATCCGACCGCCTATGAAGTCGTGGAAACGGCGA
CGCCGCGCCAGCGCACGCGTCCAAGGGATATGGTGGCGGTGGCCGCGCCTGGCTTCGCTCCCTGGTCTGCCTGA

Upstream 100 bases:

>100_bases
GCCGGTTGGCGCGGGATCCCGGTACTTTGTCTTGTGCCTTGAGCAAAGCTGCACCCTTTTAGGAATTGGCCAACGGCCGC
CTTGATTGAAAGTGACGAGA

Downstream 100 bases:

>100_bases
TCGTCGTCGCCTGGCGAGCCACTATTCATTCTCCAGTCGCCGGCCGAAAGGCCGGCATTTTCATTGCTGATTCGTTATTC
GCTGGAAGCAGCGGGTGTTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MGIELLGFQTTIANPITLKGIGVHSGSEVEITFHPADADAGIVFQRVLAGGRLSEFRAVSSHVGNTDLCTVLGLSPSTSI
ATIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSAPFIEAIEQAGVHSLPEKRRYIRILKPVRIESGASWSEFTPYDGMR
FEVEIDFDCPLIGRQSWKGDMTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLRYTDEF
VRHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATPRQRTRPRDMVAVAAPGFAPWSA

Sequences:

>Translated_317_residues
MGIELLGFQTTIANPITLKGIGVHSGSEVEITFHPADADAGIVFQRVLAGGRLSEFRAVSSHVGNTDLCTVLGLSPSTSI
ATIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSAPFIEAIEQAGVHSLPEKRRYIRILKPVRIESGASWSEFTPYDGMR
FEVEIDFDCPLIGRQSWKGDMTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLRYTDEF
VRHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATPRQRTRPRDMVAVAAPGFAPWSA
>Mature_316_residues
GIELLGFQTTIANPITLKGIGVHSGSEVEITFHPADADAGIVFQRVLAGGRLSEFRAVSSHVGNTDLCTVLGLSPSTSIA
TIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSAPFIEAIEQAGVHSLPEKRRYIRILKPVRIESGASWSEFTPYDGMRF
EVEIDFDCPLIGRQSWKGDMTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLRYTDEFV
RHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATPRQRTRPRDMVAVAAPGFAPWSA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=284, Percent_Identity=41.1971830985916, Blast_Score=239, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34504; Mature: 34372

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIELLGFQTTIANPITLKGIGVHSGSEVEITFHPADADAGIVFQRVLAGGRLSEFRAVS
CCEEEEEEHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHH
SHVGNTDLCTVLGLSPSTSIATIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSAPFIEA
HHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
IEQAGVHSLPEKRRYIRILKPVRIESGASWSEFTPYDGMRFEVEIDFDCPLIGRQSWKGD
HHHCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
MTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLRYTDEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCEEEEECCCCHHHHH
VRHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATPRQRTR
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHCC
PRDMVAVAAPGFAPWSA
CCCEEEEECCCCCCCCC
>Mature Secondary Structure 
GIELLGFQTTIANPITLKGIGVHSGSEVEITFHPADADAGIVFQRVLAGGRLSEFRAVS
CEEEEEEHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHH
SHVGNTDLCTVLGLSPSTSIATIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSAPFIEA
HHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
IEQAGVHSLPEKRRYIRILKPVRIESGASWSEFTPYDGMRFEVEIDFDCPLIGRQSWKGD
HHHCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
MTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLRYTDEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCEEEEECCCCHHHHH
VRHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATPRQRTR
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHCC
PRDMVAVAAPGFAPWSA
CCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA