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The map label for this gene is pepQ [H]

Identifier: 150397256

GI number: 150397256

Start: 2106475

End: 2108310

Strand: Direct

Name: pepQ [H]

Synonym: Smed_2055

Alternate gene names: 150397256

Gene position: 2106475-2108310 (Clockwise)

Preceding gene: 150397255

Following gene: 150397262

Centisome position: 55.7

GC content: 64.54

Gene sequence:

>1836_bases
ATGTTCCAGTCCTTCGAAGTCACCTCCACGCCTCAGTTCGGCAAGGAGAGAACCGCCGCACTGCGTACAGCCATCGCAAG
CCTGGGCGTCGATGGCTTTCTCGTGCCGCGTGCCGACGAGTTTCAGGGAGAATATGTGCCCCGCTGCTGCGAACGGCTAT
CGTGGCTGACCGGGTTTACGGGCTCGGCGGGCGTTGCGCTCGTCACGCAGCGCCAGGCGATCGTTTTCGTCGACGGCCGC
TACGTCACGCAGCTCAAGGAGCAGGTCGACGGCAGCGTCTTCACCGGCGGCGATCTCATCGGCGAACCGCCGCATGTGTG
GCTTGAGCGCCATGCACCAAAGGGTTTCCGCCTCGGCATCGATCCCTGGCTGCACACCGCAGCGGAAGTTCGCCGGCTCG
AAAAGGCGCTCGCCGCGATCGATGGCAGCCTCGTATTTCTTGACCACAATCCGCTCGACCGGCTCTGGGCCGACCGTCCG
GCGGCGCCGCTTGGTGCGGTGGCGATCCAGCCCGTCGAGCATGCGGGGCGATTGGCGAAGGAGAAGATCGCGGCAATCGC
GGCGGAAGTGGAAAAGACCAATGCCGCAGCCGTCGTTCTGACGGACCCCTCCTCCGTCGCCTGGACCTTCAATATCCGCG
GCAGCGACGTGCCCCACACCCCGCACCCTTTGGCCCGCGCCATCGTCCATTCTGACGGACGCGCGGAGCTTTTTCTCGAC
AAGCGCAAGACGGGAATCGAGCAGGAAGCCTATCTGACCCAGCTTGCAGACATAATGGCACCCGCGACCTTCGACGATCG
CCTGGCCGCCCTCGCCTCTACCGGCGCGGCAATGATGATCGACCCCGATCTCGCCCCCTTCGCCATCGGCGAGCTGATCC
GCAGGACGGAAGGCCTGGTCATAGAGGCCGCCGATCCCGCCCGCCTGCCGCGCGCCTGCAAGAATGCAGCCGAGATCGGC
GGATCGATCCGGGCGCACCTGCAGGATGGTGCGGCGATGGTTGAGTTTCTCGCCTGGCTCGACCGGGCGGAGCCCGGCAG
CGTCACCGAAATCGGCGCAGTCCGGCAGTTGGAGGCAGCGCGTGCAGCCGTCGGTGAGCGCATGCAGAACCCCCTGAAGG
ACATTTCTTTCGACACGATCGCCGGTTCCGGCCCGCATGCTGCAATCATGCACTACCGGGTCACGAACGATACCGACCGG
CCGATCGAGGCGGGAACGATGTTCCTGATCGACTCCGGCGCGCAATACGTCAACGGCACGACGGACATCACCCGCACCGT
GGCGATCGGGACAGTGCCGGAAGAGCAGAAGCGGTTCTTTACGCTCGTTCTCAAGGGCATGATCGCAATCAGCACGGCGC
GCTTCCCGAAGGGATCGCGCGGCGTCGACCTCGATCCGCTCGCCCGGATCGCGCTGTGGAAGGCCGGCGCCGATTATGCC
CATGGGACCGGTCACGGCGTCGGCTCGTATCTTTCGGTCCATGAAGGACCGCAGCGCATTGCGCGGCTTGCCACGCAGGA
ATTGTTGCCCGGCATGATGCTTTCCAACGAGCCGGGCTATTATCGCCCCGGCGCCTTCGGCATCCGTATCGAAAACCTCG
TCTTCGTTCGCGAACCGGAGGAAATCGCAGGCGGCGACCAGCCAATGCTCGGCTTCGACACGCTGACCTATTGCCCGATC
GACCGCCGGCTCGTCCTTCCCGCCCTTCTGACGGACGACGAACTCGACTGGCTGAATTCTTACCACTCGGAAACGCGGGG
GAAGCTGATGCCGCTTTTGGCCGACGGTGAGACCAGAGCCTGGTTGACCAGCGCTACGGAATCGATCGAGCGATAA

Upstream 100 bases:

>100_bases
TTATGAGTCTTGTCCCAAAACCGCTGCACATTTTCGGGCGACATGCATTAACATGCCTCGTCTCACCTTCCGTTCTCCTT
CAAGCTTACCGGGGATATCC

Downstream 100 bases:

>100_bases
ACGGAGGGGGATGCGGCAAAGTCTGTGCCCGCATCCTCTCACCTGTAGGAATGATCAGATTCATGCCTCTGGGCCGCTCC
GACCTGAAATCATCCTGGTC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MFQSFEVTSTPQFGKERTAALRTAIASLGVDGFLVPRADEFQGEYVPRCCERLSWLTGFTGSAGVALVTQRQAIVFVDGR
YVTQLKEQVDGSVFTGGDLIGEPPHVWLERHAPKGFRLGIDPWLHTAAEVRRLEKALAAIDGSLVFLDHNPLDRLWADRP
AAPLGAVAIQPVEHAGRLAKEKIAAIAAEVEKTNAAAVVLTDPSSVAWTFNIRGSDVPHTPHPLARAIVHSDGRAELFLD
KRKTGIEQEAYLTQLADIMAPATFDDRLAALASTGAAMMIDPDLAPFAIGELIRRTEGLVIEAADPARLPRACKNAAEIG
GSIRAHLQDGAAMVEFLAWLDRAEPGSVTEIGAVRQLEAARAAVGERMQNPLKDISFDTIAGSGPHAAIMHYRVTNDTDR
PIEAGTMFLIDSGAQYVNGTTDITRTVAIGTVPEEQKRFFTLVLKGMIAISTARFPKGSRGVDLDPLARIALWKAGADYA
HGTGHGVGSYLSVHEGPQRIARLATQELLPGMMLSNEPGYYRPGAFGIRIENLVFVREPEEIAGGDQPMLGFDTLTYCPI
DRRLVLPALLTDDELDWLNSYHSETRGKLMPLLADGETRAWLTSATESIER

Sequences:

>Translated_611_residues
MFQSFEVTSTPQFGKERTAALRTAIASLGVDGFLVPRADEFQGEYVPRCCERLSWLTGFTGSAGVALVTQRQAIVFVDGR
YVTQLKEQVDGSVFTGGDLIGEPPHVWLERHAPKGFRLGIDPWLHTAAEVRRLEKALAAIDGSLVFLDHNPLDRLWADRP
AAPLGAVAIQPVEHAGRLAKEKIAAIAAEVEKTNAAAVVLTDPSSVAWTFNIRGSDVPHTPHPLARAIVHSDGRAELFLD
KRKTGIEQEAYLTQLADIMAPATFDDRLAALASTGAAMMIDPDLAPFAIGELIRRTEGLVIEAADPARLPRACKNAAEIG
GSIRAHLQDGAAMVEFLAWLDRAEPGSVTEIGAVRQLEAARAAVGERMQNPLKDISFDTIAGSGPHAAIMHYRVTNDTDR
PIEAGTMFLIDSGAQYVNGTTDITRTVAIGTVPEEQKRFFTLVLKGMIAISTARFPKGSRGVDLDPLARIALWKAGADYA
HGTGHGVGSYLSVHEGPQRIARLATQELLPGMMLSNEPGYYRPGAFGIRIENLVFVREPEEIAGGDQPMLGFDTLTYCPI
DRRLVLPALLTDDELDWLNSYHSETRGKLMPLLADGETRAWLTSATESIER
>Mature_611_residues
MFQSFEVTSTPQFGKERTAALRTAIASLGVDGFLVPRADEFQGEYVPRCCERLSWLTGFTGSAGVALVTQRQAIVFVDGR
YVTQLKEQVDGSVFTGGDLIGEPPHVWLERHAPKGFRLGIDPWLHTAAEVRRLEKALAAIDGSLVFLDHNPLDRLWADRP
AAPLGAVAIQPVEHAGRLAKEKIAAIAAEVEKTNAAAVVLTDPSSVAWTFNIRGSDVPHTPHPLARAIVHSDGRAELFLD
KRKTGIEQEAYLTQLADIMAPATFDDRLAALASTGAAMMIDPDLAPFAIGELIRRTEGLVIEAADPARLPRACKNAAEIG
GSIRAHLQDGAAMVEFLAWLDRAEPGSVTEIGAVRQLEAARAAVGERMQNPLKDISFDTIAGSGPHAAIMHYRVTNDTDR
PIEAGTMFLIDSGAQYVNGTTDITRTVAIGTVPEEQKRFFTLVLKGMIAISTARFPKGSRGVDLDPLARIALWKAGADYA
HGTGHGVGSYLSVHEGPQRIARLATQELLPGMMLSNEPGYYRPGAFGIRIENLVFVREPEEIAGGDQPMLGFDTLTYCPI
DRRLVLPALLTDDELDWLNSYHSETRGKLMPLLADGETRAWLTSATESIER

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=619, Percent_Identity=35.8642972536349, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI264681565, Length=619, Percent_Identity=34.248788368336, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI93141226, Length=603, Percent_Identity=33.167495854063, Blast_Score=318, Evalue=1e-86,
Organism=Escherichia coli, GI1788728, Length=175, Percent_Identity=37.7142857142857, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17509539, Length=619, Percent_Identity=33.9256865912762, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI25149105, Length=623, Percent_Identity=29.2134831460674, Blast_Score=231, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322999, Length=656, Percent_Identity=28.8109756097561, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17137632, Length=620, Percent_Identity=33.8709677419355, Blast_Score=326, Evalue=4e-89,
Organism=Drosophila melanogaster, GI161078230, Length=610, Percent_Identity=26.5573770491803, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI21357287, Length=610, Percent_Identity=26.5573770491803, Blast_Score=219, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66275; Mature: 66275

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQSFEVTSTPQFGKERTAALRTAIASLGVDGFLVPRADEFQGEYVPRCCERLSWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHCCCCHHHHHHHHHHHHHCCC
GSAGVALVTQRQAIVFVDGRYVTQLKEQVDGSVFTGGDLIGEPPHVWLERHAPKGFRLGI
CCCCEEEEEECEEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCCEECC
DPWLHTAAEVRRLEKALAAIDGSLVFLDHNPLDRLWADRPAAPLGAVAIQPVEHAGRLAK
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCCEEECCHHHHHHHHH
EKIAAIAAEVEKTNAAAVVLTDPSSVAWTFNIRGSDVPHTPHPLARAIVHSDGRAELFLD
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEE
KRKTGIEQEAYLTQLADIMAPATFDDRLAALASTGAAMMIDPDLAPFAIGELIRRTEGLV
CHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEE
IEAADPARLPRACKNAAEIGGSIRAHLQDGAAMVEFLAWLDRAEPGSVTEIGAVRQLEAA
EECCCHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RAAVGERMQNPLKDISFDTIAGSGPHAAIMHYRVTNDTDRPIEAGTMFLIDSGAQYVNGT
HHHHHHHHHCHHHHCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCHHCCCC
TDITRTVAIGTVPEEQKRFFTLVLKGMIAISTARFPKGSRGVDLDPLARIALWKAGADYA
CHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPQRIARLATQELLPGMMLSNEPGYYRPGAFGIRIENLVFVREPE
CCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEEEEEEEEEECCH
EIAGGDQPMLGFDTLTYCPIDRRLVLPALLTDDELDWLNSYHSETRGKLMPLLADGETRA
HHCCCCCCCCCCCCEEECCCCCCEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCHH
WLTSATESIER
HHHHHHHHHCC
>Mature Secondary Structure
MFQSFEVTSTPQFGKERTAALRTAIASLGVDGFLVPRADEFQGEYVPRCCERLSWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHCCCCHHHHHHHHHHHHHCCC
GSAGVALVTQRQAIVFVDGRYVTQLKEQVDGSVFTGGDLIGEPPHVWLERHAPKGFRLGI
CCCCEEEEEECEEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCCEECC
DPWLHTAAEVRRLEKALAAIDGSLVFLDHNPLDRLWADRPAAPLGAVAIQPVEHAGRLAK
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCCEEECCHHHHHHHHH
EKIAAIAAEVEKTNAAAVVLTDPSSVAWTFNIRGSDVPHTPHPLARAIVHSDGRAELFLD
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEE
KRKTGIEQEAYLTQLADIMAPATFDDRLAALASTGAAMMIDPDLAPFAIGELIRRTEGLV
CHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEE
IEAADPARLPRACKNAAEIGGSIRAHLQDGAAMVEFLAWLDRAEPGSVTEIGAVRQLEAA
EECCCHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RAAVGERMQNPLKDISFDTIAGSGPHAAIMHYRVTNDTDRPIEAGTMFLIDSGAQYVNGT
HHHHHHHHHCHHHHCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCHHCCCC
TDITRTVAIGTVPEEQKRFFTLVLKGMIAISTARFPKGSRGVDLDPLARIALWKAGADYA
CHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPQRIARLATQELLPGMMLSNEPGYYRPGAFGIRIENLVFVREPE
CCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEEEEEEEEEECCH
EIAGGDQPMLGFDTLTYCPIDRRLVLPALLTDDELDWLNSYHSETRGKLMPLLADGETRA
HHCCCCCCCCCCCCEEECCCCCCEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCHH
WLTSATESIER
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]