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The map label for this gene is ilvC [H]

Identifier: 150397164

GI number: 150397164

Start: 2013432

End: 2014451

Strand: Reverse

Name: ilvC [H]

Synonym: Smed_1962

Alternate gene names: 150397164

Gene position: 2014451-2013432 (Counterclockwise)

Preceding gene: 150397165

Following gene: 150397162

Centisome position: 53.27

GC content: 60.2

Gene sequence:

>1020_bases
ATGCGCGTCTATTACGATCGTGATGCCGATCTCAACCTCATCAAGTCGAAGAAGGTCGCCATCATCGGCTACGGCAGCCA
AGGCCGCGCCCATGCGCTGAACCTCAAGGATTCCGGAGCGCAGAACGTCGCCATCGCGCTGAAGTCGGGTTCAGCTACGG
CAAAGAAGGCCGAAGCGGATGGTTTCAAGGTCATGACGGTTGCCGAAGCTGCGGCCTGGGCCGACCTGATGATGATGGCA
ACGCCGGACGAACTGCAGGCCGATATCTACAAGGCCGAAATCGCCGGCAATATCCGCGACGGCGCAGCGATCGCCTTTGC
GCACGGCCTGAACGTGCATTTCGGCCTGATCGAGCCGAAGGCTTCGGTCGATGTCGTGATGATCGCCCCGAAAGGCCCGG
GCCATACGGTTCGCGGCGAATACCAGAAGGGCGGCGGCGTTCCCTGCCTTGTTGCCGTTCATCAGGATGCTTCCGGCAAT
GCACTCGACCTCGCGCTCTCCTATGCCTGCGGCGTCGGCGGCGGCCGCTCGGGCATCATCGAAACCAACTTCAAGGAAGA
ATGCGAAACCGACCTCTTCGGTGAGCAGGTCGTTCTCTGCGGCGGTCTGGTCGAGCTTATCCGGGCTGGTTTCGAAACGC
TGGTCGAGGCCGGCTATGCGCCGGAGATGGCCTATTTCGAGTGCCTGCACGAAGTCAAGCTGATCGTCGACCTGATCTAT
GAAGGCGGCATTGCCAACATGAACTACTCGATCTCCAACACGGCCGAGTGGGGCGAATACGTCACCGGTCCGCGCATCAT
CACCGAAGAAACCAAGGCCGAGATGAAGCGCGTGCTGAAGGACATCCAGACCGGCAAGTTCACCTCGGAATGGATGCAGG
AGTACCGCTCCGGTGCTGCTCGCTTCAAGGGCATTCGTCGCGTCAACGACGCCCATCAGATCGAGGAAGTCGGCGCCAAG
CTGCGCGGAATGATGCCCTGGATCGGCAAGAACAAGCTGGTCGACAAGGCGAAGAACTAA

Upstream 100 bases:

>100_bases
CGGTCGACGCCTTTCTCACGCTTTACGGCGCGAAAGAGTAGGGCGGCGGTATTTTTCGGCTGCCAAAGCGAAACAGACAA
GCAAAGGGAAGGAAAATTCG

Downstream 100 bases:

>100_bases
GATCTGCCTTCAATGAAAAGAAGGAAAGCCGGAGCGCGCTCCGGCTTTCCGTTCAGGAATTGCAGCGCTTACATCGGATC
ATTGCCTTTCATGGCATTCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEADGFKVMTVAEAAAWADLMMMA
TPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPKASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGN
ALDLALSYACGVGGGRSGIIETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAARFKGIRRVNDAHQIEEVGAK
LRGMMPWIGKNKLVDKAKN

Sequences:

>Translated_339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEADGFKVMTVAEAAAWADLMMMA
TPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPKASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGN
ALDLALSYACGVGGGRSGIIETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAARFKGIRRVNDAHQIEEVGAK
LRGMMPWIGKNKLVDKAKN
>Mature_339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEADGFKVMTVAEAAAWADLMMMA
TPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPKASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGN
ALDLALSYACGVGGGRSGIIETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAARFKGIRRVNDAHQIEEVGAK
LRGMMPWIGKNKLVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=291, Percent_Identity=35.7388316151203, Blast_Score=158, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=335, Percent_Identity=29.5522388059701, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36625; Mature: 36625

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEAD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
GFKVMTVAEAAAWADLMMMATPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCC
ASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGNALDLALSYACGVGGGRSGII
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCE
ETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAA
CCCCCCCCEECCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RFKGIRRVNDAHQIEEVGAKLRGMMPWIGKNKLVDKAKN
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEAD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
GFKVMTVAEAAAWADLMMMATPDELQADIYKAEIAGNIRDGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCC
ASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGNALDLALSYACGVGGGRSGII
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCE
ETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYVTGPRIITEETKAEMKRVLKDIQTGKFTSEWMQEYRSGAA
CCCCCCCCEECCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RFKGIRRVNDAHQIEEVGAKLRGMMPWIGKNKLVDKAKN
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA